LOCUS       AJF01604.1               174 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena putative bifunctional
            cobalamin biosynthesis protein CobU: cobinamide kinase
            + cobinamide phosphate guanylyltransferase protein.
ACCESSION   CP007027-260
PROTEIN_ID  AJF01604.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="cobU"
                     /locus_tag="Y980_0254c"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /inference="protein motif:PROSITE:PS00017"
                     /note="Rv0254c, (MTV034.20) Probable cobU,cobalamin
                     biosynthesis protein including a cobinamide kinase and
                     cobinamide phosphate guanylyltransferase. Highly similar
                     to many e.g. Q05599|COBU_SALTY cobinamide kinase /
                     cobinamide phosphate guanylyltransferase from Salmonella
                     typhimurium (181 aa);
                     P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional
                     cobalamin biosynthesis protein cobU from Escherichia coli
                     strains K12 and O157:H7 (181 aa); part of
                     AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa);
                     etc. Contains PS00017 ATP/GTP-binding site motif A
                     (P-loop)."
                     /transl_table=11
                     /db_xref="GOA:L7N4T1"
                     /db_xref="InterPro:IPR003203"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:L7N4T1"
BEGIN
        1 MRILVTGGVR SGKSTHAEAL LGDAADVVYV APGRPAAGSD PDWDARVALH RARRPPTWLT
       61 VETADVATAL SEARSPVLVD CLGTWLTAIM DGEALWSAAT ADVYAVLEAR LDGLCAALTG
      121 LPTAIVVTNE VGLGVVPSHS SGVLFRDLLG TINRRVAAVC DEVHLVIAGR VLKL
//