LOCUS       AJF01572.1               487 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena putative aldehyde
            dehydrogenase protein.
ACCESSION   CP007027-228
PROTEIN_ID  AJF01572.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /locus_tag="Y980_0223c"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /inference="protein motif:PROSITE:PS00070"
                     /inference="protein motif:PROSITE:PS00687"
                     /note="Rv0223c, (MTCY08D5.18) Probable aldehyde
                     dehydrogenase, similar to others e.g.
                     A75608|6460525|AAF12231.1|AE001862_57 aldehyde
                     dehydrogenase from Deinococcus radiodurans strain R1 (495
                     aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent
                     from Gluconobacter oxydans (498 aa); etc. Also similar to
                     Rv0768, Rv2858c, etc from Mycobacterium tuberculosis.
                     Contains PS00687 Aldehyde dehydrogenases glutamic acid
                     active site; and PS00070 Aldehyde dehydrogenases cysteine
                     active site. Belongs to the aldehyde dehydrogenases
                     family."
                     /transl_table=11
                     /db_xref="GOA:P96405"
                     /db_xref="InterPro:IPR015590"
                     /db_xref="InterPro:IPR016160"
                     /db_xref="InterPro:IPR016161"
                     /db_xref="InterPro:IPR016162"
                     /db_xref="InterPro:IPR016163"
                     /db_xref="PDB:3B4W"
                     /db_xref="UniProtKB/TrEMBL:P96405"
BEGIN
        1 MSDSATEYDK LFIGGKWTKP STSDVIEVRC PATGEYVGKV PMAAAADVDA AVAAARAAFD
       61 NGPWPSTPPH ERAAVIAAAV KMLAERKDLF TKLLAAETGQ PPTIIETMHW MGSMGAMNYF
      121 AGAADKVTWT ETRTGSYGQS IVSREPVGVV GAIVAWNVPL FLAVNKIAPA LLAGCTIVLK
      181 PAAETPLTAN ALAEVFAEVG LPEGVLSVVP GGIETGQALT SNPDIDMFTF TGSSAVGREV
      241 GRRAAEMLKP CTLELGGKSA AIILEDVDLA AAIPMMVFSG VMNAGQGCVN QTRILAPRSR
      301 YDEIVAAVTN FVTALPVGPP SDPAAQIGPL ISEKQRTRVE GYIAKGIEEG ARLVCGGGRP
      361 EGLDNGFFIQ PTVFADVDNK MTIAQEEIFG PVLAIIPYDT EEDAIAIAND SVYGLAGSVW
      421 TTDVPKGIKI SQQIRTGTYG INWYAFDPGS PFGGYKNSGI GRENGPEGVE HFTQQKSVLL
      481 PMGYTVA
//