LOCUS       AJF01547.1               663 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena putative zinc metalloprotease 
            Zmp1 protein.
ACCESSION   CP007027-203
PROTEIN_ID  AJF01547.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="zmp1"
                     /locus_tag="Y980_0198c"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /inference="protein motif:PROSITE:PS00142"
                     /note="Rv0198c, (MTV033.06c) Probable zmp1,zinc
                     metalloprotease, equivalent to Z95398|MLCL622.12c from
                     Mycobacterium leprae (667 aa). Also similar to many other
                     metalloproteases e.g. members of the eukaryotic neprilysin
                     family: P08473|NEP_HUMAN neprilysin (749 aa);
                     Q07744|PEPO_LACLA neutral endopeptidase from Lactococcus
                     lactis (626 aa). Contains PS00142 Neutral zinc
                     metallopeptidases, zinc-binding region signature. Belongs
                     to peptidase family M13 (zinc metalloprotease); also known
                     as the neprilysin subfamily."
                     /transl_table=11
                     /db_xref="GOA:O53649"
                     /db_xref="InterPro:IPR000718"
                     /db_xref="InterPro:IPR008753"
                     /db_xref="InterPro:IPR018497"
                     /db_xref="InterPro:IPR024079"
                     /db_xref="PDB:3ZUK"
                     /db_xref="UniProtKB/TrEMBL:O53649"
BEGIN
        1 MTLAIPSGID LSHIDADARP QDDLFGHVNG RWLAEHEIPA DRATDGAFRS LFDRAETQVR
       61 DLIIQASQAG AAVGTDAQRI GDLYASFLDE EAVERAGVQP LHDELATIDS AADATELAAA
      121 LGTLQRAGVG GGIGVYVDTD SKDSTRYLVH FTQSGIGLPD ESYYRDEQHA AVLAAYPGHI
      181 ARMFGLVYGG ESRDHAKTAD RIVALETKLA DAHWDVVKRR DADLGYNLRT FAQLQTEGAG
      241 FDWVSWVTAL GSAPDAMTEL VVRQPDYLVT FASLWASVNV EDWKCWARWR LIRARAPWLT
      301 RALVAEDFEF YGRTLTGAQQ LRDRWKRGVS LVENLMGDAV GKLYVQRHFP PDAKSRIDTL
      361 VDNLQEAYRI SISELDWMTP QTRQRALAKL NKFTAKVGYP IKWRDYSKLA IDRDDLYGNV
      421 QRGYAVNHDR ELAKLFGPVD RDEWFMTPQT VNAYYNPGMN EIVFPAAILQ PPFFDPQADE
      481 AANYGGIGAV IGHEIGHGFD DQGAKYDGDG NLVDWWTDDD RTEFAARTKA LIEQYHAYTP
      541 RDLVDHPGPP HVQGAFTIGE NIGDLGGLSI ALLAYQLSLN GNPAPVIDGL TGMQRVFFGW
      601 AQIWRTKSRA AEAIRRLAVD PHSPPEFRCN GVVRNVDAFY QAFDVTEDDA LFLDPQRRVR
      661 IWN
//