LOCUS       AJF01537.1               575 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena putative dihydroxy-
            acid dehydratase IlvD (dad) protein.
ACCESSION   CP007027-193
PROTEIN_ID  AJF01537.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="ilvD"
                     /locus_tag="Y980_0189c"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /inference="protein motif:PROSITE:PS00886"
                     /note="Rv0189c, (MTCI28.28c) Probable ilvD,dihydroxy-acid
                     dehydratase, similar to many e.g. ILVD_LACLA|Q02139
                     dihydroxy-acid dehydratase (dad) from Lactococcus lactis
                     (subsp. lactis) (Streptococcus lactis) (570 aa). Also
                     similar to ML2608|MLCL622.06c|O06069|ILVD_MYCLE
                     dihydroxy-acid dehydratase from Mycobacterium leprae (564
                     aa). Contains PS00886 Dihydroxy-acid and
                     6-phosphogluconate dehydratases signature 1. Belongs to
                     the ILVD / EDD family. Cofactor: binds 1 4FE-4S cluster
                     (potential)."
                     /transl_table=11
                     /db_xref="GOA:P65154"
                     /db_xref="InterPro:IPR000581"
                     /db_xref="InterPro:IPR004404"
                     /db_xref="InterPro:IPR015928"
                     /db_xref="InterPro:IPR020558"
                     /db_xref="UniProtKB/Swiss-Prot:P65154"
BEGIN
        1 MPQTTDEAAS VSTVADIKPR SRDVTDGLEK AAARGMLRAV GMDDEDFAKP QIGVASSWNE
       61 ITPCNLSLDR LANAVKEGVF SAGGYPLEFG TISVSDGISM GHEGMHFSLV SREVIADSVE
      121 VVMQAERLDG SVLLAGCDKS LPGMLMAAAR LDLAAVFLYA GSILPGRAKL SDGSERDVTI
      181 IDAFEAVGAC SRGLMSRADV DAIERAICPG EGACGGMYTA NTMASAAEAL GMSLPGSAAP
      241 PATDRRRDGF ARRSGQAVVE LLRRGITARD ILTKEAFENA IAVVMAFGGS TNAVLHLLAI
      301 AHEANVALSL QDFSRIGSGV PHLADVKPFG RHVMSDVDHI GGVPVVMKAL LDAGLLHGDC
      361 LTVTGHTMAE NLAAITPPDP DGKVLRALAN PIHPSGGITI LHGSLAPEGA VVKTAGFDSD
      421 VFEGTARVFD GERAALDALE DGTITVGDAV VIRYEGPKGG PGMREMLAIT GAIKGAGLGK
      481 DVLLLTDGRF SGGTTGLCVG HIAPEAVDGG PIALLRNGDR IRLDVAGRVL DVLADPAEFA
      541 SRQQDFSPPP PRYTTGVLSK YVKLVSSAAV GAVCG
//