LOCUS       AJF01516.1               454 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena Mce-family protein
            Mce1A protein.
ACCESSION   CP007027-172
PROTEIN_ID  AJF01516.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="mce1A"
                     /locus_tag="Y980_0169"
                     /gene_synonym="mce1"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /note="Rv0169, (MTCI28.09) Mce1A; belongs to 24-membered
                     Mycobacterium tuberculosis Mce protein family (see
                     citations below), highly similar to Mycobacterium
                     tuberculosis proteins
                     O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa);
                     O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also
                     highly similar to others e.g.
                     AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry
                     protein from Mycobacterium bovis BCG (454 aa);
                     NP_302656.1|NC_002677 putative cell invasion protein from
                     Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene
                     product from Mycobacterium avium (88 aa) (similarity on
                     C-terminus); CAC12798.1|AL445327 putative secreted protein
                     from Streptomyces coelicolor (418 aa); etc. Note that
                     equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901
                     Mcep protein from Mycobacterium tuberculosis (432 aa).
                     Contains a very hydrophobic region around residues 20-35.
                     Note that previously known as mce1. A core mycobacterial
                     gene; conserved in mycobacterial strains (See Marmiesse et
                     al., 2004). Predicted to be an outer membrane protein (See
                     Song et al., 2008)."
                     /transl_table=11
                     /db_xref="InterPro:IPR003399"
                     /db_xref="InterPro:IPR005693"
                     /db_xref="InterPro:IPR024516"
                     /db_xref="UniProtKB/TrEMBL:F5BH89"
BEGIN
        1 MTTPGKLNKA RVPPYKTAGL GLVLVFALVV ALVYLQFRGE FTPKTQLTML SARAGLVMDP
       61 GSKVTYNGVE IGRVDTISEV TRDGESAAKF ILDVDPRYIH LIPANVNADI KATTVFGGKY
      121 VSLTTPKNPT KRRITPKDVI DVRSVTTEIN TLFQTLTSIA EKVDPVKLNL TLSAAAEALT
      181 GLGDKFGESI VNANTVLDDL NSRMPQSRHD IQQLAALGDV YADAAPDLFD FLDSSVTTAR
      241 TINAQQAELD SALLAAAGFG NTTADVFDRG GPYLQRGVAD LVPTATLLDT YSPELFCTIR
      301 NFYDADPLAK AASGGGNGYS LRTNSEILSG IGISLLSPLA LATNGAAIGI GLVAGLIAPP
      361 LAVAANLAGA LPGIVGGAPN PYTYPENLPR VNARGGPGGA PGCWQPITRD LWPAPYLVMD
      421 TGASLAPYNH MEVGSPYAVE YVWGRQVGDN TINP
//