LOCUS       AJF01401.1               874 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena putative replicative
            DNA helicase DnaB protein.
ACCESSION   CP007027-57
PROTEIN_ID  AJF01401.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="dnaB"
                     /locus_tag="Y980_0058"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /inference="protein motif:PROSITE:PS00017"
                     /note="Rv0058, (MTV030.01, MTCY21D4.21) Probable dnaB,
                     replicative DNA helicase. Contains an intein (position
                     61630..62838) similar to, and in the same position as,
                     those in Sycnechocystis and Rhodothermus marinus (see
                     citation below) and C-terminal extein (position
                     62839..63015) similar to many dnaB proteins. This protein
                     undergoes a protein self splicing that involves a
                     post-translational excision of the intervening region
                     (intein) followed by peptide ligation. Belongs to the
                     helicase family, DNAB subfamily. In the intein section;
                     belongs to the homing endonuclease family."
                     /transl_table=11
                     /db_xref="GOA:P71715"
                     /db_xref="InterPro:IPR003586"
                     /db_xref="InterPro:IPR003587"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR004042"
                     /db_xref="InterPro:IPR006141"
                     /db_xref="InterPro:IPR006142"
                     /db_xref="InterPro:IPR007692"
                     /db_xref="InterPro:IPR007693"
                     /db_xref="InterPro:IPR007694"
                     /db_xref="InterPro:IPR016136"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR027434"
                     /db_xref="PDB:2R5U"
                     /db_xref="UniProtKB/Swiss-Prot:P71715"
BEGIN
        1 MAVVDDLAPG MDSSPPSEDY GRQPPQDLAA EQSVLGGMLL SKDAIADVLE RLRPGDFYRP
       61 AHQNVYDAIL DLYGRGEPAD AVTVAAELDR RGLLRRIGGA PYLHTLISTV PTAANAGYYA
      121 SIVAEKALLR RLVEAGTRVV QYGYAGAEGA DVAEVVDRAQ AEIYDVADRR LSEDFVALED
      181 LLQPTMDEID AIASSGGLAR GVATGFTELD EVTNGLHPGQ MVIVAARPGV GKSTLGLDFM
      241 RSCSIRHRMA SVIFSLEMSK SEIVMRLLSA EAKIKLSDMR SGRMSDDDWT RLARRMSEIS
      301 EAPLFIDDSP NLTMMEIRAK ARRLRQKANL KLIVVDYLQL MTSGKKYESR QVEVSEFSRH
      361 LKLLAKELEV PVVAISQLNR GPEQRTDKKP MLADLRESGC LTASTRILRA DTGAEVAFGE
      421 LMRSGERPMV WSLDERLRMV ARPMINVFPS GRKEVFRLRL ASGREVEATG SHPFMKFEGW
      481 TPLAQLKVGD RIAAPRRVPE PIDTQRMPES ELISLARMIG DGSCLKNQPI RYEPVDEANL
      541 AAVTVSAAHS DRAAIRDDYL AARVPSLRPA RQRLPRGRCT PIAAWLAGLG LFTKRSHEKC
      601 VPEAVFRAPN DQVALFLRHL WSAGGSVRWD PTNGQGRVYY GSTSRRLIDD VAQLLLRVGI
      661 FSWITHAPKL GGHDSWRLHI HGAKDQVRFL RHVGVHGAEA VAAQEMLRQL KGPVRNPNLD
      721 SAPKKVWAQV RNRLSAKQMM DIQLHEPTMW KHSPSRSRPH RAEARIEDRA IHELARGDAY
      781 WDTVVEITSI GDQHVFDGTV SGTHNFVANG ISLHNSLEQD ADVVILLHRP DAFDRDDPRG
      841 GEADFILAKH RNGPTKTVTV AHQLHLSRFA NMAR
//