LOCUS AJF01393.1 677 aa PRT BCT 20-JUN-2017 DEFINITION Mycobacterium tuberculosis H37RvSiena putative bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) protein. ACCESSION CP007027-49 PROTEIN_ID AJF01393.1 SOURCE Mycobacterium tuberculosis H37RvSiena ORGANISM Mycobacterium tuberculosis H37RvSiena Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 (bases 1 to 4410911) AUTHORS Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G. TITLE Genomic polymorphisms in a Laboratory Isolate of Mycobacterium tuberculosis Reference Strain H37Rv (ATCC27294) JOURNAL New Microbiol. 40 (1), 62-69 (2017) PUBMED 27819398 REFERENCE 2 (bases 1 to 4410911) AUTHORS Guerrini,V., Santoro,F. and Pozzi,G. TITLE Direct Submission JOURNAL Submitted (30-DEC-2013) Medical Biotechnology, University of Siena, viale Bracci, Policlinico Le Scotte, Siena 53100, Italy REFERENCE 3 (bases 1 to 4410911) AUTHORS Guerrini,V., Santoro,F. and Pozzi,G. TITLE Direct Submission JOURNAL Submitted (20-FEB-2015) Medical Biotechnology, University of Siena, viale Bracci, Policlinico Le Scotte, Siena 53100, Italy REMARK Protein update by submitter COMMENT Annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (released 2013). Information about the Pipeline can be found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Annotation modified by submitter. ##Assembly-Data-START## Assembly Method :: Ray v. 2.3.1 Coverage :: 300 Sequencing Technology :: Illumina ##Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Date :: 12/30/2013 09:28:23 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline Annotation Method :: Best-placed reference protein set; GeneMarkS+ Annotation Software revision :: 2.3 (rev. 422554) Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region Genes :: 4,146 CDS :: 4,050 Pseudo Genes :: 42 CRISPR Arrays :: 2 rRNAs :: 3 (5S, 16S, 23S) tRNAs :: 45 ncRNA :: 6 Frameshifted Genes :: 34 ##Genome-Annotation-Data-END## FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37RvSiena" /mol_type="genomic DNA" /strain="H37RvSiena" /db_xref="taxon:1437856" protein /gene="ponA1" /locus_tag="Y980_0050" /experiment="EXISTENCE: identified in proteomics study" /note="Rv0050, (MTCY21D4.13) Probable ponA1,penicillin-binding protein (class A), bienzymatic protein with transglycosylase and transpeptidase activities (see Graham & Clark-Curtiss 1999), highly similar to many (see Billman-Jacobe et al., 1999). Belongs to the transglycosylase family in the N-terminal section, and to the transpeptidase family in the C-terminal section." /transl_table=11 /db_xref="GOA:P71707" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="UniProtKB/Swiss-Prot:P71707" BEGIN 1 MVILLPMVTF TMAYLIVDVP KPGDIRTNQV STILASDGSE IAKIVPPEGN RVDVNLSQVP 61 MHVRQAVIAA EDRNFYSNPG FSFTGFARAV KNNLFGGDLQ GGSTITQQYV KNALVGSAQH 121 GWSGLMRKAK ELVIATKMSG EWSKDDVLQA YLNIIYFGRG AYGISAASKA YFDKPVEQLT 181 VAEGALLAAL IRRPSTLDPA VDPEGAHARW NWVLDGMVET KALSPNDRAA QVFPETVPPD 241 LARAENQTKG PNGLIERQVT RELLELFNID EQTLNTQGLV VTTTIDPQAQ RAAEKAVAKY 301 LDGQDPDMRA AVVSIDPHNG AVRAYYGGDN ANGFDFAQAG LQTGSSFKVF ALVAALEQGI 361 GLGYQVDSSP LTVDGIKITN VEGEGCGTCN IAEALKMSLN TSYYRLMLKL NGGPQAVADA 421 AHQAGIASSF PGVAHTLSED GKGGPPNNGI VLGQYQTRVI DMASAYATLA ASGIYHPPHF 481 VQKVVSANGQ VLFDASTADN TGDQRIPKAV ADNVTAAMEP IAGYSRGHNL AGGRDSAAKT 541 GTTQFGDTTA NKDAWMVGYT PSLSTAVWVG TVKGDEPLVT ASGAAIYGSG LPSDIWKATM 601 DGALKGTSNE TFPKPTEVGG YAGVPPPPPS EVPPSETVIQ PTVEIAPGIT IPIGPPTTIT 661 LAPPPPAPPA ATPTPPP //