LOCUS       AJF01349.1               675 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena DNA gyrase (subunit
            B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase
            II) (type II DNA topoisomerase) protein.
ACCESSION   CP007027-5
PROTEIN_ID  AJF01349.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="gyrB"
                     /locus_tag="Y980_0005"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /inference="protein motif:PROSITE:PS00177"
                     /note="Rv0005, (MTCY10H4.03) GyrB, DNA gyrase subunit B
                     (see citations below). Contains PS00177 DNA topoisomerase
                     II signature. Belongs to the type II topoisomerase family.
                     Start changed since first submission (-39 aa)."
                     /transl_table=11
                     /db_xref="GOA:P0C5C5"
                     /db_xref="InterPro:IPR001241"
                     /db_xref="InterPro:IPR002288"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR006171"
                     /db_xref="InterPro:IPR011557"
                     /db_xref="InterPro:IPR013506"
                     /db_xref="InterPro:IPR013759"
                     /db_xref="InterPro:IPR013760"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR018522"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="PDB:2ZJT"
                     /db_xref="PDB:3IG0"
                     /db_xref="PDB:3M4I"
                     /db_xref="UniProtKB/Swiss-Prot:P0C5C5"
BEGIN
        1 MAAQKKKAQD EYGAASITIL EGLEAVRKRP GMYIGSTGER GLHHLIWEVV DNAVDEAMAG
       61 YATTVNVVLL EDGGVEVADD GRGIPVATHA SGIPTVDVVM TQLHAGGKFD SDAYAISGGL
      121 HGVGVSVVNA LSTRLEVEIK RDGYEWSQVY EKSEPLGLKQ GAPTKKTGST VRFWADPAVF
      181 ETTEYDFETV ARRLQEMAFL NKGLTINLTD ERVTQDEVVD EVVSDVAEAP KSASERAAES
      241 TAPHKVKSRT FHYPGGLVDF VKHINRTKNA IHSSIVDFSG KGTGHEVEIA MQWNAGYSES
      301 VHTFANTINT HEGGTHEEGF RSALTSVVNK YAKDRKLLKD KDPNLTGDDI REGLAAVISV
      361 KVSEPQFEGQ TKTKLGNTEV KSFVQKVCNE QLTHWFEANP TDAKVVVNKA VSSAQARIAA
      421 RKARELVRRK SATDIGGLPG KLADCRSTDP RKSELYVVEG DSAGGSAKSG RDSMFQAILP
      481 LRGKIINVEK ARIDRVLKNT EVQAIITALG TGIHDEFDIG KLRYHKIVLM ADADVDGQHI
      541 STLLLTLLFR FMRPLIENGH VFLAQPPLYK LKWQRSDPEF AYSDRERDGL LEAGLKAGKK
      601 INKEDGIQRY KGLGEMDAKE LWETTMDPSV RVLRQVTLDD AAAADELFSI LMGEDVDARR
      661 SFITRNAKDV RFLDV
//