LOCUS       AEJ33666.1                90 aa    PRT              VRL 02-JUL-2013
DEFINITION  Human betaherpesvirus 5 protein RL8A protein.
ACCESSION   AY446894-4
PROTEIN_ID  AEJ33666.1
SOURCE      Human betaherpesvirus 5 (HHV-5; HCMV)
  ORGANISM  Human betaherpesvirus 5
            Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
            Herviviricetes; Herpesvirales; Orthoherpesviridae;
            Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE   1  (bases 1 to 235646)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235646)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235646)
  AUTHORS   McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
  TITLE     The most abundantly transcribed human cytomegalovirus gene (beta
            2.7) is non-essential for growth in vitro
  JOURNAL   J. Gen. Virol. 84 (PT 9), 2511-2516 (2003)
   PUBMED   12917473
REFERENCE   4  (bases 1 to 235646)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   5  (bases 1 to 235646)
  AUTHORS   Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J.,
            Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W.
            and Davison,A.J.
  TITLE     High-resolution human cytomegalovirus transcriptome
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011)
   PUBMED   22109557
REFERENCE   6  (bases 1 to 235646)
  AUTHORS   Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G.
  TITLE     Direct Submission
  JOURNAL   Unpublished
  REMARK    Consensus viral genome sequence in the original urine sample
            confirmed from Illumina data as being identical, except for the
            mutation at 176311
REFERENCE   7  (bases 1 to 235646)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
REFERENCE   8  (bases 1 to 235646)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
REFERENCE   9  (bases 1 to 235646)
  AUTHORS   McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JUN-2003) Infection and Immunity, University of Wales
            College of Medicine, Tenovus Building, Heath Park, Cardiff CF14
            4XX, UK
REFERENCE   10 (bases 1 to 235646)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
REFERENCE   11 (bases 1 to 235646)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
  REMARK    Sequence update by submitter
COMMENT     On or before Aug 14, 2009 this sequence version replaced
            AY156043.1, AY169797.2, AY325310.1, AY446894.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="Merlin"
                     /isolation_source="urine from a congenitally infected
                     child"
                     /host="Homo sapiens"
                     /culture_collection="ATCC:VR-1590"
                     /db_xref="taxon:10359"
                     /country="United Kingdom: Cardiff"
                     /collection_date="1999"
                     /collected_by="Gavin W.G. Wilkinson"
                     /note="originally named strain 742; passaged 3 times in
                     human fibroblasts; gene UL128 is mutated; populations of
                     mutants in RL13 predominate, but the consensus sequence of
                     this gene is not mutated;
                     acronym: HHV-5; HCMV"
     protein         /gene="RL8A"
                     /locus_tag="HHV5wtgr003"
                     /note="contains potential transmembrane domain"
BEGIN
        1 MPHGHLRQAL SPTSWTCEGL LLLLGLLVLF FHHHNQSAVE RRRRVSFVEA DRLPHESGWY
       61 SSDDDGDRDG DEETGESHNR NSVGLSAVFS
//