LOCUS       ADD39178.1               354 aa    PRT              VRL 12-OCT-2016
DEFINITION  Human betaherpesvirus 5 envelope protein US28 protein.
ACCESSION   GU937742-160
PROTEIN_ID  ADD39178.1
SOURCE      Human betaherpesvirus 5 (HHV-5)
  ORGANISM  Human betaherpesvirus 5
            Viruses; Duplodnaviria; Heunggongvirae; Peploviricota;
            Herviviricetes; Herpesvirales; Orthoherpesviridae;
            Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5.
REFERENCE   1  (bases 1 to 235404)
  AUTHORS   Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and
            Wilkinson,G.W.
  TITLE     Homology between the human cytomegalovirus RL11 gene family and
            human adenovirus E3 genes
  JOURNAL   J. Gen. Virol. 84 (PT 3), 657-663 (2003)
   PUBMED   12604818
REFERENCE   2  (bases 1 to 235404)
  AUTHORS   Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C.,
            Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D.,
            Wilkinson,G.W. and Davison,A.J.
  TITLE     Two novel spliced genes in human cytomegalovirus
  JOURNAL   J. Gen. Virol. 84 (PT 5), 1117-1122 (2003)
   PUBMED   12692276
REFERENCE   3  (bases 1 to 235404)
  AUTHORS   Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L.,
            Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C.,
            Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and
            Davison,A.J.
  TITLE     Genetic content of wild-type human cytomegalovirus
  JOURNAL   J. Gen. Virol. 85 (PT 5), 1301-1312 (2004)
   PUBMED   15105547
REFERENCE   4  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Human cytomegalovirus RL11 gene family: variation, recombination
            and transcription
  JOURNAL   Unpublished
REFERENCE   5  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-FEB-2010) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
REFERENCE   6  (bases 1 to 235404)
  AUTHORS   Davison,A.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-OCT-2016) MRC Virology Unit, Church Street, Glasgow
            G11 5JR, UK
  REMARK    Sequence update by submitter
COMMENT     On Oct 12, 2016 this sequence version replaced GU937742.1.
            The original gene nomenclature has been retained. Genes presumably
            inherited from the common ancestor of alpha-, beta- and
            gammaherpesviruses (core genes), from the common ancestor of beta-
            and gammaherpesviruses (betagamma genes), or from the common
            ancestor of betaherpesviruses (beta genes) are indicated. A
            standard protein nomenclature has been applied so that orthologs
            have the same name in all herpesviruses.
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 5"
                     /mol_type="genomic DNA"
                     /strain="Toledo"
                     /isolation_source="urine from a congenitally infected
                     infant"
                     /host="Homo sapiens"
                     /db_xref="taxon:10359"
                     /country="USA"
                     /collection_date="1984"
                     /note="passaged several times in human fibroblasts;
                     contains inversion of 14336 bp region (genes UL128 to
                     UL133); 3 genes are mutated (RL13, UL9 and UL128);
                     acronym: HCMV; acronym: HHV-5"
     protein         /gene="US28"
                     /note="type 3 membrane protein; 7 transmembrane domains;
                     broad spectrum CC chemokine receptor; constitutive
                     signalling; mediates cellular migration; involved in
                     intracellular signalling; GPCR family"
BEGIN
        1 MTPTTTTAEL TTEFDYDEAA TPCVFTDVLN QSKPVTLFLY GVVFLFGSIG NFLVIFTITW
       61 RRRIQCSGDV YFINLAAADL LFVCTLPLWM QYLLDHNSLA SVPCTLLTAC FYVAMFASLC
      121 FITEIALDRY YAIVYMRYRP VKQACLFSIF WWIFAVIIAI PHFMVVTKKN NQCMTDYDYL
      181 EVSYPIILNV ELMLGAFVIP LSVISYCYYR ISRIVAVSQS RHKGRIVRVL IAVVLVFIIF
      241 WLPYHLTLFV DTLKLLKWIS SSCEFERSLK RALILTESLA FCHCCLNPLL YVFVGTKFRQ
      301 ELHCLLAEFR QRLFSRDVSW YHSMSFSRRS SPSRRETSSD TLSDEVCRVS QIIP
//