LOCUS ADD39108.1 2242 aa PRT VRL 12-OCT-2016 DEFINITION Human betaherpesvirus 5 large tegument protein protein. ACCESSION GU937742-53 PROTEIN_ID ADD39108.1 SOURCE Human betaherpesvirus 5 (HHV-5) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235404) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235404) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235404) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 4 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Human cytomegalovirus RL11 gene family: variation, recombination and transcription JOURNAL Unpublished REFERENCE 5 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (26-FEB-2010) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 6 (bases 1 to 235404) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (12-OCT-2016) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REMARK Sequence update by submitter COMMENT On Oct 12, 2016 this sequence version replaced GU937742.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="Toledo" /isolation_source="urine from a congenitally infected infant" /host="Homo sapiens" /db_xref="taxon:10359" /country="USA" /collection_date="1984" /note="passaged several times in human fibroblasts; contains inversion of 14336 bp region (genes UL128 to UL133); 3 genes are mutated (RL13, UL9 and UL128); acronym: HCMV; acronym: HHV-5" protein /gene="UL48" /note="complexed with tegument protein UL37; ubiquitin-specific protease (N-terminal region); involved in capsid transport" BEGIN 1 MKVTQASCHQ GDIARFGARA GNQCVCNGIM FLHALHLGGT SAVLQTEALD AIMEEGARLD 61 ARLERELQKK LPAGGRLPVY RLGDEVPRRL ESRFGRTVHA LSRPFNGTTE TCDLDGYMCP 121 GIFDFLRYAH AKPRPTYVLV TVNSSARAVV FTEDHMLVFD PHSSAECHNA AVYHCEGLHQ 181 VLMVLTGFGV QLSPAFYYEA LFLYMLDVAT VPEAEIAARL VSTYRDRDID LTGVVRESVD 241 TAATTTTAAP SLPPLPDPIV DPGCPPGVAP SIPVYDPSSS PKKTPEKRRK DLSGSKHGGK 301 KKPPSTTSKT LATASSSSPS AIAAASSSST VPPSYSCGEG ALPALGRYQQ LVDEVEQELK 361 ALTLPPLPAN TSAWTLHAAG TENGANAATA TAPSFDEAFL TDRLQQLIIH AVNQRSCLRR 421 PCGPQSAAQQ AVRAYLGLSK KLDAFLLNWL HHGLDLRRMH DYLSHKTTKD TYSMLDRALL 481 EKMQVVFDPY GRQHGPALIA WVEEMLRYVE SKPTNELSQR LQRFVTKRPM PVSDSFICLR 541 PVDFQRLTQV IEQRRRVLQR QREEYHGVYE HLAGLITSID IHDLDASDLN RREILKALQP 601 LDDNAKQELF RLGNAKMLEL QMDLDRLSTQ LLTRVHNHIL NGFLPVEDLK QMERVVEQVL 661 RLFYDLRDLK LCDGSYEEGF VVIREQLSYL MTGTVRDNVP LLQEILQLRH AYQQATQQNE 721 GRLTQIHDLL HVIETLVRDP GSRGSALTLA LVQEQLAQLE ALGGLQLPEV QQRLQNAQLA 781 LSRLYEEEEE TQRFLDGLSY DDPPTEQTIK RHPQLREMLR RDEQTRLRLI NAVLSMFHTL 841 VMRLARDESP RPTFFDAVSL LLQQLPPDSH EREDLRAANA TYAQMVKKLE QIEKAGTGAS 901 EKRFQALREL VYFFRNHEYF FQHMVGRLGV GPQVTELYER YQHEMEEQHL ERLEREWQEE 961 AGKLTVTSVE DVQRVLARAP SHRVMHQMQQ TLTTKMQDFL DKEKRKQEEQ QRQLLDGYQK 1021 KVQQDLQRVV DAVKGEMLST IPHQPLEATL ELLLGLDQRA QPLLDKFNQD LLSALQQLSK 1081 KLDGRINECL HGVLTGDVER RCHPHREAAM QTQASLNHLD QILGPQLLIH ETQQALQHAV 1141 HQAQFIEKCQ QGDPTTAITG SEFEGDFVRY RSSQQKMEGQ LQETRQQMTE TSERLDRSLR 1201 QDPGSSSVTR VPEKPFKGQE LAGRITPPPA DFQRPVFKTL LDQQADAARK ALSDEADLLN 1261 QKVQTQLRQR DEQLSTAQNL WTDLVTRHKM SGGLDVTTPD AKALMEKPLE TLRELLGKAT 1321 QQLPYLSAER TVRWMLAFLE EALAQITTDP THPHHGSRTH YRNLQQQAVE SAVTLAHQIE 1381 QNAACENFIA QHQEATANGA STPRVDMVQA VEAVWQRLEP GRVAGGAARH QKVQELLQRL 1441 GQTLGDLELQ ETLATEYFAL LHGIQTFSYG LDFRSQLEKI RDLRTRFAEL AKQRGTRLSN 1501 EGALPNPRKP QATTSLGAFT RGLNALERHV QLGHQYLLNK LNGSSLVYRL EDIPSVLPPT 1561 HETDPALIMR DRLRRLCFAR HHDTFLEVVD VFGMRQIVTQ AGEPIHLVTD YGNVAFKYLA 1621 LRDDGRPLAW RRRCSGGGLK NVVTTRYKAI TVAVAVCQTL RTFWPQISQY DLRPYLTQHQ 1681 SHTHPAETHT LHNLKLFCYL VSTAWHQRID TQQELTAADR VGSGEGGDVG EQRPGRGTVL 1741 RLSLQEFCVL IAALYPEYIY TVLKYPVQMS LPSLTAHLHQ DVIHAVVNNT HKMPPDHLPE 1801 QVKAFCITPT QWPAMQLNKL FWENKLVQQL CQVGPQKSTP PLGKLWLYAM ATLVFPQDML 1861 QCLWLELKPQ YAETYASVSE LVQTLFQIFT QQCEMVTEGY TQPQLPTGEP VLQMIRVRRQ 1921 DTTTTDTNTT TEPGLLDVFI QTETALDYAL GSWLFGIPVC LGVHVADLLK GQRILVARHL 1981 EYTSRDRDFL RIQRSRDLNL SQLLQDTWTE TPLEHCWLQA QIRRLRDYLR FPTRLEFIPL 2041 VIYNAQDHTV VRVLRPPSTF EQDHSRLVLD EAFPTFPLYD QDDNSSADNV AASGAAPTPP 2101 VPFNRVPVNI QFLRENPPPI ARVQQPPRRH RHRAAAAADD DGQIDHVQDD TSRTADSALV 2161 STAFGGSVFQ ENRLGETPLC RDELVAVAPG AASTSFASPP ITVLTQNVLS ALEILRLVRL 2221 DLRQLAQSVQ DTIQHMRFLY LL //