LOCUS ACS93397.1 1242 aa PRT VRL 09-MAY-2013 DEFINITION Human betaherpesvirus 5 DNA polymerase catalytic subunit protein. ACCESSION GQ221974-60 PROTEIN_ID ACS93397.1 SOURCE Human betaherpesvirus 5 (HHV-5) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235154) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235154) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235154) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 4 (bases 1 to 235154) AUTHORS Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H., Wilkinson,G.W. and Tomasec,P. TITLE Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18 JOURNAL J. Gen. Virol. 86 (PT 11), 2999-3008 (2005) PUBMED 16227221 REFERENCE 5 (bases 1 to 235154) AUTHORS Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J., Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and Davison,A.J. TITLE Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens JOURNAL J. Gen. Virol. 91 (PT 3), 605-615 (2010) PUBMED 19906940 REFERENCE 6 (bases 1 to 235154) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK COMMENT On or before Aug 17, 2009 this sequence version replaced AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1, AY325311.1, DQ195526.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="3157" /isolation_source="urine from a congenitally infected infant" /host="Homo sapiens" /db_xref="taxon:10359" /country="United Kingdom" /collection_date="2001" /note="sequenced at passage 3 in human fibroblasts; three genes are mutated (RL13, UL40 and UL128); acronym: HCMV; acronym: HHV-5" protein /gene="UL54" /EC_number="2.7.7.7" /note="involved in DNA replication" BEGIN 1 MFFNPYLSGG VTGGAVAGGR RQRSQPGSAQ GSGKRPPQKQ FLQIVPRGVM FDGQTGLIKH 61 KTGRLPLMFY REIKHLLSHD MVWPCPWRET LVGRVVGPIR FHTYDQTDAV LFFDSPENVS 121 PRYRQHLVPS GNVLRFFGAT EHGYSICVNV FGQRSYFYCE YSDTDRLREV IASVGELVPE 181 PRTPYAVSVT PATKTSIYGY GTRPVPDLQC VSISNWTMAR KIGEYLLEQG FPVYEVRVDP 241 LTRLVIDRRI TTFGWCSVNR YDWRQQGRAS TCDIEVDCDV SDLVAVPDDS SWPRYRCLSF 301 DIECMSGEGG FPCAEKSDDI VIQISCVCYE TGGNTAVDQG IPNGNDGRGC TSEGVIFGHS 361 GLHLFTIGTC GQVGPDVDVY EFPSEYELLL GFMLFFQRYA PAFVTGYNIN SFDLKYILTR 421 LEYLYKVDSQ RFCKLPTAQG GRFFLHSPAV GFKRQYAAAF PSASHNNPAS TAATKVYIAG 481 SVVIDMYPVC MAKTNSPNYK LNTMAELYLR QRKDDLSYKD IPRCFVANAE GRAQVGRYCL 541 QDAVLVRDLF NTINFHYEAG AIARLAKIPL RRVIFDGQQI RIYTSLLDEC ACRDFILPNH 601 YSKGTTVPET NSVAVSPNAA IISTAAVPGD AGSVAAMFQM SPPLQSAPSS QDGVSPGSGS 661 NSSSSVGVFS VGSGSSGGVG VSNDNHGAGG TAAVSYQGAT VFEPEVGYYN DPVAVFDFAS 721 LYPSIIMAHN LCYSTLLVPG GEYPVDPADV YSVTLENGVT HRFVRASVRV SVLSELLNKW 781 VSQRRAVREC MRECQDPVRR MLLDKEQMAL KVTCNAFYGF TGVVNGMMPC LPIAASITRI 841 GRDMLERTAR FIKDNFSEPC FLHNFFNQED YVVGTREGDS EESSTLPEGL ETSSGGLNER 901 RVEARVIYGD TDSVFVRFRG LTPQALVARG PSLAHYVTAC LFVEPVKLEF EKVFVSLMMI 961 CKKRYIGKVE GASGLSMKGV DLVRKTACEF VKGVTRDVLS LLFEDREVSE AAVRLSRLSL 1021 DEVKKYGVPR GFWRILRRLV QARDDLYLHR VCVEDLVLSS VLSKDISLYR QSNLPHIAVI 1081 KRLAARSEEL PSVGDRVFYV LTAPGVRTAP QGSSDNGDSV TTGVVSRSDA IDGTDDDADG 1141 GGVEESNRRG GEPAKKRARK PPSAVCNYEV AEDPSYVREH GVPIHADKYF EQVLKAVTNV 1201 LSPVFPGGET ARKDKFLHMV LPRRLHLEPA FLPYSVKAHE CC //