LOCUS ACS93390.1 2240 aa PRT VRL 09-MAY-2013 DEFINITION Human betaherpesvirus 5 large tegument protein protein. ACCESSION GQ221974-53 PROTEIN_ID ACS93390.1 SOURCE Human betaherpesvirus 5 (HHV-5) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235154) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235154) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235154) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 4 (bases 1 to 235154) AUTHORS Griffin,C., Wang,E.C., McSharry,B.P., Rickards,C., Browne,H., Wilkinson,G.W. and Tomasec,P. TITLE Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18 JOURNAL J. Gen. Virol. 86 (PT 11), 2999-3008 (2005) PUBMED 16227221 REFERENCE 5 (bases 1 to 235154) AUTHORS Cunningham,C., Gatherer,D., Hilfrich,B., Baluchova,K., Dargan,D.J., Thomson,M., Griffiths,P.D., Wilkinson,G.W., Schulz,T.F. and Davison,A.J. TITLE Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens JOURNAL J. Gen. Virol. 91 (PT 3), 605-615 (2010) PUBMED 19906940 REFERENCE 6 (bases 1 to 235154) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (28-MAY-2009) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK COMMENT On or before Aug 17, 2009 this sequence version replaced AY446863.1, AY446867.1, AY446875.1, AY169795.2, AY156040.1, AY325311.1, DQ195526.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="3157" /isolation_source="urine from a congenitally infected infant" /host="Homo sapiens" /db_xref="taxon:10359" /country="United Kingdom" /collection_date="2001" /note="sequenced at passage 3 in human fibroblasts; three genes are mutated (RL13, UL40 and UL128); acronym: HCMV; acronym: HHV-5" protein /gene="UL48" /note="complexed with tegument protein UL37; ubiquitin-specific protease (N-terminal region); involved in capsid transport" BEGIN 1 MKVTQASCHQ GDIARFGARA GNQCVCNGIM FLHALHLGGT SAVLQTEALD AIMEEGARLD 61 ARLERELQKK LPAGGRLPVY RLGDEVPRRL ESRFGRTVHA LSRPFNGTTE TCDLDGYMCP 121 GIFDFLRYAH AKPRPTYVLV TVNSLARAVV FTEDHMLVFD PHSSAECHNA AVYHCEGLHQ 181 VLMVLTGFGV QLSPAFYYEA LFLYMLDVAT VPEAEIAARL VSTYRDRDID LTGVVRESAD 241 TAATTTTAAP SLPPLPDPIV DPGCPPGVAP SIPVYDPSSS PKKTPEKRRK DLSGSKHGGK 301 KKPPSTTSKT LATASSSSAI AAASSSSAVP PSYSCGEGAL PALGRYQQLV DEVEQELKAL 361 TLPPLPANTS AWTLHAAGTE SGANAATATA PSFDEAFLTD RLQQLIIHAV NQRSCLRRPC 421 GPQSAAQQAV RAYLGLSKKL DAFLLNWLHH GLDLRRMHDY LSHKTTKGTY STLDRALLEK 481 MQVVFDPYGR QHGPALIAWV EEMLRYVESK PTNELSQRLQ RFVTKRPMPV SDSFVCLRPV 541 DFQRLTQVIE QRRRVLQRQR EEYHGVYEHL AGLITSIDIH DLDASDLNRR EILKALQPLD 601 DNAKQELFRL GNAKMLELQM DLDRLSTQLL TRVHNHILNG FLPVEDLKQM ERVVEQVLRL 661 FYDLRDLKLC DGSYEEGFVV IREQLSYLMT GTVRDNVPLL QEILQLRHAY QQATQQNEGR 721 LTQIHDLLHV IETLVRDPGS RGSALTLALV QEQLAQLEAL GGLQLPEVQQ RLQNAQLALS 781 RLYEEEEETQ RFLDGLSYDD PPTEQTIKRH PQLREMLRRD EQTRLRLINA VLSMFHTLVM 841 RLARDESPRP TFFDAVSLLL QQLPPDSHER EDLRAANATY AQMVKKLEQI EKAGTGASEK 901 RFQALRELVY FFRNHEYFFQ HMVGRLGVGP QVTELYERYQ HEMEEQHLER LEREWQEEAG 961 KLTVTSVEDV QRVLARAPSH RVMHQMQQTL TTKMQDFLDK EKRKQEEQQR QLLDGYQKKV 1021 QQDLQRVVDA VKGEMLSTIP HQPLEATLEL LLGLDQRAQP LLDKFNQDLL SALQQLSKKL 1081 DGRINECLHG VLTGDVERRC HPHREAAMQT QASLNHLDQI LGPQLLIHET QQALQHAVHQ 1141 AQFIEKCQQG DPTTAIMGSE FEGDFARYRS SQQKMEGQLQ ETRQQMTETS ERLDRSLRQD 1201 PGSSSVTRVP EKPFKGQELA GRITPPPADF QRPVFKTLLD QQADAARKAL SDEADLLNQK 1261 VQTQLRQRDE QLSTAQNLWT DLVTRHKMSG GLDVTTPDAK ALMEKPLETL RELLGKATQQ 1321 LPYLSAERTV RWMLAFLEEA LAQITADPTH PHHGSRTHYR NLQQQAVESA VTLAHQIEQN 1381 AACENFIAQH QEATANGAST PRVDMVQAVE AVWQRLEPGR VAGGAARHQK VQELLQRLGQ 1441 TLGDLELQET LATEYFALLH GIQTFSYGLD FRSQLEKIRD LRTRFAELAK RRGTRLSNEG 1501 ALPNPRKPQA TTSLGAFTRG LNALERHVQL GHQYLLNKLN GSSLVYRLED IPSVLPPTHE 1561 TDPALIMRDR LRRLCFARHH DTFLEVVDVF GMRQIVTQAG EPIHLVTDYG NVAFKYLALR 1621 DDGRPLAWRR RCSGGGLKNV VTTRYKAITV AVAVCQTLRT FWPQISQYDL RPYLTQHQSH 1681 THPAETHTLH NLKLFCYLVS TAWHQRIDTQ QELTAADRVG SGEGGDVGEQ RPGRGTVLRL 1741 SLQEFCVLIA ALYPEYIYTV LKYPVQMSLP SLTAHLHQDV IHAVVNNTHK MPPDHLPEQV 1801 KAFCITPTQW PAMQLNKLFW ENKLVQQLCQ VGPQKSTPPL GKLWLYAMAT LVFPQDMLQC 1861 LWLELKPQYA ETYASVSELV QTLFQIFTQQ CEMVTEGYTQ PQLPTGEPVL QMIRVRRQDT 1921 TTTDTNTTTE PGLLDVFIQT ETALDYALGS WLFGIPVCLG VHVADLLKGQ RVLVARHLEY 1981 TSRDRDFLRI QRSRDLNLSQ LLQDTWTETP LEHCWLQAQI RRLRDYLRFP TRLEFIPLVI 2041 YNAQDHTVVR VLRPPSTFEQ DHSRLVLDEA FPTFPLYDQD DNTSADNVAA SGAALTPPVP 2101 FNRVPVNIQF LRENPPPIAR VQQPPRRHRH RAAAAADDDG QIDHVQDDTS RTADSALVST 2161 AFGGSVFQEN RLGETPLCRD ELVAVAPGAA STSFASPPIT VLTQNVLSAL EILRLVRLDL 2221 RQLAQSVQDT IQHMRFLYLL //