LOCUS AAR31652.1 873 aa PRT VRL 02-JUL-2013 DEFINITION Human betaherpesvirus 5 helicase-primase subunit protein. ACCESSION AY446894-97 PROTEIN_ID AAR31652.1 SOURCE Human betaherpesvirus 5 (HHV-5; HCMV) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235646) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235646) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235646) AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W. TITLE The most abundantly transcribed human cytomegalovirus gene (beta 2.7) is non-essential for growth in vitro JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003) PUBMED 12917473 REFERENCE 4 (bases 1 to 235646) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 5 (bases 1 to 235646) AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J., Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W. and Davison,A.J. TITLE High-resolution human cytomegalovirus transcriptome JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011) PUBMED 22109557 REFERENCE 6 (bases 1 to 235646) AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G. TITLE Direct Submission JOURNAL Unpublished REMARK Consensus viral genome sequence in the original urine sample confirmed from Illumina data as being identical, except for the mutation at 176311 REFERENCE 7 (bases 1 to 235646) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Direct Submission JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 8 (bases 1 to 235646) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Direct Submission JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 9 (bases 1 to 235646) AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W. TITLE Direct Submission JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF14 4XX, UK REFERENCE 10 (bases 1 to 235646) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 11 (bases 1 to 235646) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REMARK Sequence update by submitter COMMENT On or before Aug 14, 2009 this sequence version replaced AY156043.1, AY169797.2, AY325310.1, AY446894.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="Merlin" /isolation_source="urine from a congenitally infected child" /host="Homo sapiens" /culture_collection="ATCC:VR-1590" /db_xref="taxon:10359" /country="United Kingdom: Cardiff" /collection_date="1999" /collected_by="Gavin W.G. Wilkinson" /note="originally named strain 742; passaged 3 times in human fibroblasts; gene UL128 is mutated; populations of mutants in RL13 predominate, but the consensus sequence of this gene is not mutated; acronym: HHV-5; HCMV" protein /gene="UL102" /locus_tag="HHV5wtgp094" /note="involved in DNA replication" BEGIN 1 MTAQPPLHHR HHPYTLFGTS CHLSWYGLLE ASVPIVQCLF LDLGGGRAEP RLHTFVVRGD 61 RLPPAEVRAV HRASYAALAS AVTTDADERR RGLEQRSAVL ARVLLEGSAL IRVLARTFTP 121 VQIQTDASGV EILEAAPALG VETTALSNAL SLFHVAKLVV IGSYPEVHEP RVVTHAAERV 181 SEEYGTHAHK KLRRGYYAYD LAMSFRVGTH KYVLERDDEA VLARLFEVRE VCFLRTCLRL 241 VTPVGFVAVA VTDEQCCLLL QSAWTHLYDV LFRGFAGQPP LRDYLGPDLF ETGAARSFFF 301 PGFPPVPVYA VHGLHTLMRE TALDAAAEVL SWCGLPDIVG SAGKLEVEPC ALSLGVPEDE 361 WQVFGTEAGG GAVRLNATAF RERPAGGDRR WLLPPLPRDD GDGENNVVEV SSSTGGAHPP 421 SDDATFTVHV RDATLHRVLI VDLVERVLAK CVRARDFNPY VRYSHRLHTY AVCEKFIENL 481 RFRSRRAFWQ IQSLLGYISE HVTSACASAG LLWVLSRGHR EFYVYDGYSG HGPVSAEVCV 541 RTVVDCYWRK LFGGDDPGPT CRVQESAPGV LLVWGDERLV GPFNFFYGNG GAGGSPLHGV 601 VGGFAAGHCG GACCAGCVVT HRHSSGGGGS GVGDADHASG GGLDAAAGSG HNGGSDRVSP 661 STPPAALGGC CCAAGGDWLS AVGHVLGRLP ALLRERVSVS ELEAVYREIL FRFVARRNDV 721 DFWLLRFQPG ENEVRPHAGV IDCAPFHGVW AEQGQIIVQS RDTALAADIG YGVYVDKAFA 781 MLTACVEVWA RELLSSSTAS TTTCSSSSVL SSALPSVTSS SSGTATVSPP SCSSSSATWL 841 EERDEWVRSL AVDAQHAAKR VASEGLRFFR LNA //