LOCUS AAR31635.1 561 aa PRT VRL 02-JUL-2013 DEFINITION Human betaherpesvirus 5 tegument protein pp65 protein. ACCESSION AY446894-80 PROTEIN_ID AAR31635.1 SOURCE Human betaherpesvirus 5 (HHV-5; HCMV) ORGANISM Human betaherpesvirus 5 Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; Cytomegalovirus humanbeta5. REFERENCE 1 (bases 1 to 235646) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Homology between the human cytomegalovirus RL11 gene family and human adenovirus E3 genes JOURNAL J. Gen. Virol. 84 (PT 3), 657-663 (2003) PUBMED 12604818 REFERENCE 2 (bases 1 to 235646) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Two novel spliced genes in human cytomegalovirus JOURNAL J. Gen. Virol. 84 (PT 5), 1117-1122 (2003) PUBMED 12692276 REFERENCE 3 (bases 1 to 235646) AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W. TITLE The most abundantly transcribed human cytomegalovirus gene (beta 2.7) is non-essential for growth in vitro JOURNAL J. Gen. Virol. 84 (PT 9), 2511-2516 (2003) PUBMED 12917473 REFERENCE 4 (bases 1 to 235646) AUTHORS Dolan,A., Cunningham,C., Hector,R.D., Hassan-Walker,A.F., Lee,L., Addison,C., Dargan,D.J., McGeoch,D.J., Gatherer,D., Emery,V.C., Griffiths,P.D., Sinzger,C., McSharry,B.P., Wilkinson,G.W. and Davison,A.J. TITLE Genetic content of wild-type human cytomegalovirus JOURNAL J. Gen. Virol. 85 (PT 5), 1301-1312 (2004) PUBMED 15105547 REFERENCE 5 (bases 1 to 235646) AUTHORS Gatherer,D., Seirafian,S., Cunningham,C., Holton,M., Dargan,D.J., Baluchova,K., Hector,R.D., Galbraith,J., Herzyk,P., Wilkinson,G.W. and Davison,A.J. TITLE High-resolution human cytomegalovirus transcriptome JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19755-19760 (2011) PUBMED 22109557 REFERENCE 6 (bases 1 to 235646) AUTHORS Wilkie,G.S., Davison,A.J., Stanton,R.J. and Wilkinson,G.W.G. TITLE Direct Submission JOURNAL Unpublished REMARK Consensus viral genome sequence in the original urine sample confirmed from Illumina data as being identical, except for the mutation at 176311 REFERENCE 7 (bases 1 to 235646) AUTHORS Davison,A.J., Akter,P., Cunningham,C., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D. and Wilkinson,G.W. TITLE Direct Submission JOURNAL Submitted (27-SEP-2002) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 8 (bases 1 to 235646) AUTHORS Akter,P., Cunningham,C., McSharry,B.P., Dolan,A., Addison,C., Dargan,D.J., Hassan-Walker,A.F., Emery,V.C., Griffiths,P.D., Wilkinson,G.W. and Davison,A.J. TITLE Direct Submission JOURNAL Submitted (29-OCT-2002) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 9 (bases 1 to 235646) AUTHORS McSharry,B.P., Tomasec,P., Neale,M.L. and Wilkinson,G.W. TITLE Direct Submission JOURNAL Submitted (18-JUN-2003) Infection and Immunity, University of Wales College of Medicine, Tenovus Building, Heath Park, Cardiff CF14 4XX, UK REFERENCE 10 (bases 1 to 235646) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (22-OCT-2003) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REFERENCE 11 (bases 1 to 235646) AUTHORS Davison,A.J. TITLE Direct Submission JOURNAL Submitted (13-AUG-2007) MRC Virology Unit, Church Street, Glasgow G11 5JR, UK REMARK Sequence update by submitter COMMENT On or before Aug 14, 2009 this sequence version replaced AY156043.1, AY169797.2, AY325310.1, AY446894.1. The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes), from the common ancestor of beta- and gammaherpesviruses (betagamma genes), or from the common ancestor of betaherpesviruses (beta genes) are indicated. A standard protein nomenclature has been applied so that orthologs have the same name in all herpesviruses. FEATURES Qualifiers source /organism="Human betaherpesvirus 5" /mol_type="genomic DNA" /strain="Merlin" /isolation_source="urine from a congenitally infected child" /host="Homo sapiens" /culture_collection="ATCC:VR-1590" /db_xref="taxon:10359" /country="United Kingdom: Cardiff" /collection_date="1999" /collected_by="Gavin W.G. Wilkinson" /note="originally named strain 742; passaged 3 times in human fibroblasts; gene UL128 is mutated; populations of mutants in RL13 predominate, but the consensus sequence of this gene is not mutated; acronym: HHV-5; HCMV" protein /gene="UL83" /locus_tag="HHV5wtgp077" /note="lower matrix protein; involved in immune regulation; suppresses interferon response; inhibits NK cell cytotoxicity; binds NKp30; DURP family" BEGIN 1 MESRGRRCPE MISVLGPISG HVLKAVFSRG DTPVLPHETR LLQTGIHVRV SQPSLILVSQ 61 YTPDSTPCHR GDNQLQVQHT YFTGSEVENV SVNVHNPTGR SICPSQEPMS IYVYALPLKM 121 LNIPSINVHH YPSAAERKHR HLPVADAVIH ASGKQMWQAR LTVSGLAWTR QQNQWKEPDV 181 YYTSAFVFPT KDVALRHVVC AHELVCSMEN TRATKMQVIG DQYVKVYLES FCEDVPSGKL 241 FMHVTLGSDV EEDLTMTRNP QPFMRPHERN GFTVLCPKNM IIKPGKISHI MLDVAFTSHE 301 HFGLLCPKSI PGLSISGNLL MNGQQIFLEV QAIRETVELR QYDPVAALFF FDIDLLLQRG 361 PQYSEHPTFT SQYRIQGKLE YRHTWDRHDE GAAQGDDDVW TSGSDSDEEL VTTERKTPRV 421 TGGGAMASAS TSAGRKRKSA SSATACTAGV MTRGRLKAES TVAPEEDTDE DSDNEIHNPA 481 VFTWPPWQAG ILARNLVPMV ATVQGQNLKY QEFFWDANDI YRIFAELEGV WQPAAQPKRR 541 RHRQDALPGP CIASTPKKHR G //