LOCUS       AAL88745.1              1325 aa    PRT              HUM 07-OCT-2002
DEFINITION  Homo sapiens multidrug resistance-associated protein protein.
ACCESSION   AY081219-1
PROTEIN_ID  AAL88745.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5759)
  AUTHORS   Adachi,M., Sampath,J., Lan,L.B., Sun,D., Hargrove,P., Flatley,R.,
            Tatum,A., Edwards,M.Z., Wezeman,M., Matherly,L., Drake,R. and
            Schuetz,J.
  TITLE     Expression of MRP4 confers resistance to ganciclovir and
            compromises bystander cell killing
  JOURNAL   J. Biol. Chem. 277 (41), 38998-39004 (2002)
   PUBMED   12105214
REFERENCE   2  (bases 1 to 5759)
  AUTHORS   Adachi,M., Sampath,J., Sun,D. and Schuetz,J.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-FEB-2002) Pharmaceutical Sciences, St. Jude
            Children's Research Hospital, 332 North Lauderdale St., Memphis, TN
            38105-2794, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000084242"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     protein         /gene="ABCC4"
                     /gene_synonym="MRP4"
                     /note="ATP-binding cassette sub-family C (CFTR/MRP) member
                     4"
BEGIN
        1 MLPVYQEVKP NPLQDANICS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE DRSQHLGEEL
       61 QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL IEESAKVIQP IFLGKIINYF
      121 ENYDPMDSVA LNTAYAYATV LTFCTLILAI LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR
      181 LSNMAMGKTT TGQIVNLLSN DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG
      241 MAVLIILLPL QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT
      301 NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR VFVAVTLYGA
      361 VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR QLPSDGKKMV HVQDFTAFWD
      421 KASETPTLQG LSFTVRPGEL LAVVGPVGAG KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ
      481 QPWVFSGTLR SNILFGKKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK
      541 ARVNLARAVY QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA
      601 SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR NRTFSESSVW
      661 SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA YKSYFRAGAH WIVFIFLILL
      721 NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN GGGNVTGKLD LNWYLGIYSG LTVATVLFGI
      781 ARSLLVFYVL VNSSQTLHNK MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF
      841 LDFIQTLLQV VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLGSTTRSPV
      901 FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV RLDAICAMFV
      961 IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS AEVENMMISV ERVIEYTDLE
     1021 KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY SPGGPLVLKH LTALIKSQEK VGIVGRTGAG
     1081 KSSLISALFR LSEPEGKIWI DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE
     1141 HTDEELWNAL QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII
     1201 DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG RLKEYDEPYV
     1261 LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI GHTDHMVTNT SNGQPSTLTI
     1321 FETAL
//