LOCUS       AAK71923.1               267 aa    PRT              HUM 11-JUL-2001
DEFINITION  Homo sapiens alkaline phytoceramidase protein.
ACCESSION   AF214454-1
PROTEIN_ID  AAK71923.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3404)
  AUTHORS   Mao,C., Xu,R., Szulc,Z.M., Bielawska,A., Galadari,S.H. and
            Obeid,L.M.
  TITLE     Cloning and characterization of a novel human alkaline ceramidase.
            A mammalian enzyme that hydrolyzes phytoceramide
  JOURNAL   J. Biol. Chem. 276 (28), 26577-26588 (2001)
   PUBMED   11356846
REFERENCE   2  (bases 1 to 3404)
  AUTHORS   Mao,C., Xu,R. and Obeid,L.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-DEC-1999) Medicine, Medical University of SC, 114
            Doughty Street, Charleston, SC 29425, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000074114"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /tissue_type="kidney"
     protein         /gene="APHC"
                     /function="hydrolyzes phytoceramide into phytosphingosine
                     and fatty acid"
                     /note="aPHC; similar to Saccharomyces cerevisiae alkaline
                     ceramidase YPC1p but lacks reverse activity of
                     synthesizing phytoceramide from phytosphingosine and a
                     fatty acid"
BEGIN
        1 MAPAADREGY WGPTTSTLDW CEENYSVTWY IAEFWNTVSN LIMIIPPMFG AIQSVRDGLE
       61 KRYIASYLAL TVVGMGSWCF HMTLKYEMQL LDELPMIYSC CIFVYCMFEC FKIKNSVNYH
      121 LLFTLVLFSL IVTTVYLKVK EPIFHQVMYG MLVFTLVLRS IYIVTWVYPW LRGLGYTSLG
      181 IFLLGFLFWN IDNIFCESLR NFRKKVPPII GITTQFHAWW HILTGLGSYL HILFSLYTRT
      241 LYLRYRPKVK FLFGIWPVIL FEPLRKH
//