LOCUS       AAF97028.1              1315 aa    PRT              HUM 03-AUG-2000
DEFINITION  Homo sapiens FUSED serine/threonine kinase protein.
ACCESSION   AF200815-1
PROTEIN_ID  AAF97028.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3948)
  AUTHORS   Murone,M., Luoh,S.M., Stone,D., Li,W., Gurney,A., Armanini,M.,
            Grey,C., Rosenthal,A. and de Sauvage,F.J.
  TITLE     Gli regulation by the opposing activities of fused and suppressor
            of fused
  JOURNAL   Nat. Cell Biol. 2 (5), 310-312 (2000)
   PUBMED   10806483
REFERENCE   2  (bases 1 to 3948)
  AUTHORS   Murone,M., Luoh,S.-L., Stone,D., Li,W., Gurney,A., Armanini. M.,
            Grey,C., Rosenthal,A. and de Sauvage,F.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-NOV-1999) Molecular Oncology, Genentech Inc., 1 DNA
            Way, South San Francisco, CA 94080, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000073757"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     protein         /function="modulator of Gli activity"
                     /note="Hedgehog signal transduction"
BEGIN
        1 MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH
       61 PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR
      121 ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT
      181 ADLWSVGCIL YELAVGTPPF YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR
      241 QRLSWPDLLY HPFIAGHVTI ITEPAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR
      301 ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE SSLLAGILAS
      361 ELKSSWAKSG TGEVPSAPRE NRTTPDCERA FPEERPEVLG QRSTDVVDLE NEEPDSDNEW
      421 QHLLETTEPV PIQLKAPLTL LCNPDFCQRI QSQLHEAGGQ ILKGILEGAS HILPAFRVLS
      481 SLLSSCSDSV ALYSFCREAG LPGLLLSLLR HSQESNSLQQ QSWYGTFLQD LMAVIQAYFA
      541 CTFNLERSQT SDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN
      601 SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPQGA PQVSQPLREQ SEDIPGAISS
      661 ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS LISGLQHPIL CLHLLKVLYS
      721 CCLVSEGLCR LLGQEPLALE SLFMLIQGKV KVVDWEESTE VTLYFLSLLV FRLQNLPCGM
      781 EKLGSDVATL FTHSHVVSLV SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL
      841 TPPGSCGFYD GLLILLLQLL TEQGKASLIR DMSSSEMWTV LWHRFSMVLR LPEEASAQEG
      901 ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI LMSILKHLLC
      961 PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL LIVVLADLRD SEVAAHLLQV
     1021 CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ FVNTVSASPR TIVSFLSVAL LSDQPLLTSD
     1081 LLSLLAHTAR VLSPSHLSFI QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS
     1141 MALRGALQSQ SGLLSLLLLG LGDKDPVVRC SASFAVGNAA YQAGPLGPAL AAAVPSMTQL
     1201 LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK EAALIALRSL
     1261 QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK HCRKLIHLLR PAHSM
//