LOCUS       AAF75548.1               345 aa    PRT              HUM 12-JUN-2000
DEFINITION  Homo sapiens PAR6 protein.
ACCESSION   AF265565-1
PROTEIN_ID  AAF75548.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1246)
  AUTHORS   Qiu,R.G., Abo,A. and Steven Martin,G.
  TITLE     A human homolog of the C. elegans polarity determinant Par-6 links
            Rac and Cdc42 to PKCzeta signaling and cell transformation
  JOURNAL   Curr. Biol. 10 (12), 697-707 (2000)
   PUBMED   10873802
REFERENCE   2  (bases 1 to 1246)
  AUTHORS   Qiu,R.-G. and Martin,G.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAY-2000) Molecular and Cell Biology, University of
            California, Berkeley, 401 Barker Hall #3204, Berkeley, CA
            94720-3204, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000075550"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     protein         /gene="PAR6"
                     /function="mediates cell transformation by Rac/Cdc42"
                     /note="effector of Rac and Cdc42; binds atypical PKCs;
                     similar to Caenorhabditis elegans polarity protein Par-6;
                     contains PDZ and CRIB domains"
BEGIN
        1 MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRASVSGFQ EFSRLLRAVH QIPGLDVLLG
       61 YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKREADSS GLAFASNSLQ RRKKGLLLRP
      121 VAPLRTRPPL LISLPQDFRQ VSSVIDVDLL PETHRRVRLH KHGSDRPLGF YIRDGMSVRV
      181 APQGLERVPG IFISRLVRGG LAESTGLLAV SDEILEVNGI EVAGKTLDQV TDMMVANSHN
      241 LIVTVKPANQ RNNVVRGASG RLTGPPSAGP GPAEPDSDDD SSDLVIENRQ PPSSNGLSQG
      301 PPCWDLHPGC RHPGTRSSLP SLDDQEQASS GWGSRIRGDG SGFSL
//