LOCUS       AAF66596.1               458 aa    PRT              HUM 25-SEP-2000
DEFINITION  Homo sapiens serine protease Htra2 protein.
ACCESSION   AF141305-1
PROTEIN_ID  AAF66596.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Gray,C.W., Ward,R.V., Karran,E., Turconi,S., Rowles,A.,
            Viglienghi,D., Southan,C., Barton,A., Fantom,K.G., West,A.,
            Savopoulos,J., Hassan,N.J., Clinkenbeard,H., Hanning,C.,
            Amegadzie,B., Davis,J.B., Dingwall,C., Livi,G.P. and Creasy,C.L.
  TITLE     Characterization of human HtrA2, a novel serine protease involved
            in the mammalian cellular stress response
  JOURNAL   Eur. J. Biochem. 267 (18), 5699-5710 (2000)
   PUBMED   10971580
REFERENCE   2  (bases 1 to 2187)
  AUTHORS   Creasy,C.L., Southan,C.D., Livi,G.P., Clinkenbeard,H., Browne,M.
            and Eric Karran.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-APR-1999) Comparative Genetics, SmithKline Beecham
            Pharmaceuticals, Inc., 709 Swedeland Road, King of Prussia, PA
            19406, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000071154"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13"
                     /tissue_type="brain"
                     /dev_stage="fetus; adult"
     protein         /note="alternatively spliced"
BEGIN
        1 MAAPRAGRGA GWSLRAWRAL GGIRWGRRPR LTPDLRALLT SGTSDPRARV TYGTPSLWAR
       61 LSVGVTEPRA CLTSGTPGPR AQLTAVTPDT RTREASENSG TRSRAWLAVA LGAGGAVLLL
      121 LWGGGRGPPA VLAAVPSPPP ASPRSQYNFI ADVVEKTAPA VVYIEILDRH PFLGREVPIS
      181 NGSGFVVAAD GLIVTNAHVV ADRRRVRVRL LSGDTYEAVV TAVDPVADIA TLRIQTKEPL
      241 PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA
      301 IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS SSGISGSQRR
      361 YIGVMMLTLS PSILAELQLR EPSFPDVQHG VLIHKVILGS PAHRAGLRPG DVILAIGEQM
      421 VQNAEDVYEA VRTQSQLAVQ IRRGRETLTL YVTPEVTE
//