LOCUS       AAF43432.1               355 aa    PRT              HUM 14-JUL-2000
DEFINITION  Homo sapiens sir2-related protein type 6 protein.
ACCESSION   AF233396-1
PROTEIN_ID  AAF43432.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1638)
  AUTHORS   Frye,R.A.
  TITLE     Phylogenetic classification of prokaryotic and eukaryotic Sir2-like
            proteins
  JOURNAL   Biochem. Biophys. Res. Commun. 273 (2), 793-798 (2000)
   PUBMED   10873683
REFERENCE   2  (bases 1 to 1638)
  AUTHORS   Frye,R.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-2000) Pathology, VA Med. Center, University of
            Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000074679"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3; between CDC34 and D19S325"
                     /tissue_type="spleen"
     protein         /gene="SIRT6"
                     /function="putatively binds and cleaves N-acetyl bonds"
                     /function="metabolizes NAD"
                     /function="ADP-ribosyltransferase activity"
                     /note="sirtuin6; similar to yeast silent information
                     regulator 2 protein, sir2p"
BEGIN
        1 MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG
       61 IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV
      121 RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE
      181 LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN
      241 LQPTKHDRHA DLRIHGYVDE VMTRLMEHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK
      301 EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS
//