LOCUS       AAD40853.1               310 aa    PRT              HUM 26-JUN-1999
DEFINITION  Homo sapiens sirtuin type 5 protein.
ACCESSION   AF083110-1
PROTEIN_ID  AAD40853.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1633)
  AUTHORS   Frye,R.A.
  TITLE     Characterization of five human cDNAs with homology to the yeast
            SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may
            have protein ADP-ribosyltransferase activity
  JOURNAL   Biochem. Biophys. Res. Commun. 260 (1), 273-279 (1999)
   PUBMED   10381378
REFERENCE   2  (bases 1 to 1633)
  AUTHORS   Frye,R.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-1998) Pathology, VA Med. Cent. (132L), Univ. of
            Pittsburgh, University Drive C, Pittsburgh, PA 15240, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000066543"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="testis"
     protein         /gene="SIRT5"
                     /note="yeast silent information regulator 2 (Sir2p)
                     homolog; similar to prokaryotic sirtuins"
BEGIN
        1 MRPLQIVPSR LISQLYCGLK PPASTRNQIC LKMARPSSSM ADFRKFFAKA KHIVIISGAG
       61 VSAESGVPTF RGAGGYWRKW QAQDLATPLA FAHNPSRVWE FYHYRREVMG SKEPNAGHRA
      121 IAECETRLGK QGRRVVVITQ NIDELHRKAG TKNLLEIHGS LFKTRCTSCG VVAENYKSPI
      181 CPALSGKGAP EPGTQDASIP VEKLPRCEEA GCGGLLRPHV VWFGENLDPA ILEEVDRELA
      241 HCDLCLVVGT SSVVYPAAMF APQVAARGVP VAEFNTETTP ATNRFRFHFQ GPCGTTLPEA
      301 LACHENETVS
//