LOCUS       AAC39638.1               726 aa    PRT              HUM 06-MAR-1998
DEFINITION  Homo sapiens cyclin T protein.
ACCESSION   AF045161-1
PROTEIN_ID  AAC39638.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2181)
  AUTHORS   Wei,P., Garber,M.E., Fang,S.M., Fischer,W.H. and Jones,K.A.
  TITLE     A novel CDK9-associated C-type cyclin interacts directly with HIV-1
            Tat and mediates its high-affinity, loop-specific binding to TAR
            RNA
  JOURNAL   Cell 92 (4), 451-462 (1998)
   PUBMED   9491887
REFERENCE   2  (bases 1 to 2181)
  AUTHORS   Wei,P., Garber,M.E., Fang,S.M., Fischer,W.H. and Jones,K.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JAN-1998) Regulatory Biology, The Salk Institute,
            10010 N. Torrey Pines Road, La Jolla, CA 92037, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000063975"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="270 cR from top"
                     /clone_lib="Jurkat"
     protein         /function="C-type cyclin partner for CDK9 (PITALRE)"
                     /note="87 kDa nuclear protein; required for RNAPII
                     transcription elongation at many genes; interacts
                     specifically with the transcriptional activation domain of
                     HIV-1 Tat; binds co-operatively with Tat to TAR RNA;
                     TAK/P-TEFb transcription elongation factor complex
                     component; confirmed by peptide sequence analysis of the
                     HeLa cyclin T protein; is widely expressed"
BEGIN
        1 MEGERKNNNK RWYFTREQLE NSPSRRFGVD PDKELSYRQQ AANLLQDMGQ RLNVSQLTIN
       61 TAIVYMHRFY MIQSFTQFPG NSVAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD
      121 TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN
      181 SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE
      241 FLQILEKTPN RLKRIWNWRA CEAAKKTKAD DRGTDEKTSE QTILNMISQS SSDTTIAGLM
      301 SMSTSTTSAV PSLPVSEESS SNLTSVEMLP GKRWLSSQPS FKLEPTQGHR TSENLALTGV
      361 DHSLPQDGSN AFISQKQNSK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY
      421 AAQNLLSHHD SHSSVILKMP IEGSENPERP FLEKADKTAL KMRIPVAGGD KAASSKPEEI
      481 KMRIKVHAAA DKHNSVEDSV TKSREHKEKH KTHPSNHHHH HNHHSHKHSH SQLPVGTGNK
      541 RPGDPKHSSQ TSNLAHKTYS LSSSFSSSSS TRKRGPSEET GGAVFDHPAK IAKSTKSSSL
      601 NFSFPSLPTM GQMPGHSSDT SGLSFSQPSC KTRVPHSKLD KGPTGANGHN TTQTIDYQDT
      661 VNMLHSLLSA QGVQPTQPTA FEFVRPYSDY LNPRSGGISS RSGNTDKPRP PPLPSEPPPP
      721 LPPLPK
//