LOCUS AAB50257.1 116 aa PRT VRL 21-OCT-2002 DEFINITION Human immunodeficiency virus 1 protein ( Human immunodeficiency virus type 1 (HXB2), complete genome; HIV1/HTLV-III/LAV reference genome. ). ACCESSION K03455-6 PROTEIN_ID AAB50257.1 SOURCE Human immunodeficiency virus 1 (HIV-1) ORGANISM Human immunodeficiency virus 1 Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. REFERENCE 1 (sites) AUTHORS van Beveren,C.P., Coffin,J. and Hughes,S. TITLE Appendix B: HTLV-3/LAV genome JOURNAL (in) Weiss,R.L., Teich,N., Varmus,H. and Coffin,J. (Eds.); RNA TUMOR VIRUSES, SECOND EDITION, 2, Vol. 2: 1102-1123; Cold Spring Harbor Laboratory, Cold Spring Harbor (1985) REFERENCE 2 (bases 493 to 674; 9577 to 9718) AUTHORS Ratner,L., Haseltine,W., Patarca,R., Livak,K.J., Starcich,B., Josephs,S.F., Doran,E.R., Rafalski,J.A., Whitehorn,E.A., Baumeister,K., Ivanoff,L., Petteway,S.R. Jr., Pearson,M.L., Lautenberger,J.A., Papas,T.S., Ghrayeb,J., Chang,N.T., Gallo,R.C. and Wong-Staal,F. TITLE Complete nucleotide sequence of the AIDS virus, HTLV-III JOURNAL Nature 313 (6000), 277-284 (1985) PUBMED 2578615 REFERENCE 3 (bases 1 to 653) AUTHORS Starcich,B., Ratner,L., Josephs,S.F., Okamoto,T., Gallo,R.C. and Wong-Staal,F. TITLE Characterization of long terminal repeat sequences of HTLV-III JOURNAL Science 227 (4686), 538-540 (1985) PUBMED 2981438 REFERENCE 4 (sites) AUTHORS Allan,J.S., Coligan,J.E., Barin,F., McLane,M.F., Sodroski,J.G., Rosen,C.A., Haseltine,W.A., Lee,T.H. and Essex,M. TITLE Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III JOURNAL Science 228 (4703), 1091-1094 (1985) PUBMED 2986290 REFERENCE 5 (sites) AUTHORS Rosen,C.A., Sodroski,J.G. and Haseltine,W.A. TITLE The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat JOURNAL Cell 41 (3), 813-823 (1985) PUBMED 2988790 REFERENCE 6 (sites) AUTHORS Arya,S.K., Guo,C., Josephs,S.F. and Wong-Staal,F. TITLE Trans-activator gene of human T-lymphotropic virus type III (HTLV-III) JOURNAL Science 229 (4708), 69-73 (1985) PUBMED 2990040 REFERENCE 7 (sites) AUTHORS Sodroski,J., Patarca,R., Rosen,C., Wong-Staal,F. and Haseltine,W. TITLE Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III JOURNAL Science 229 (4708), 74-77 (1985) PUBMED 2990041 REFERENCE 8 (sites) AUTHORS Rabson,A.B., Daugherty,D.F., Venkatesan,S., Boulukos,K.E., Benn,S.I., Folks,T.M., Feorino,P. and Martin,M.A. TITLE Transcription of novel open reading frames of AIDS retrovirus during infection of lymphocytes JOURNAL Science 229 (4720), 1388-1390 (1985) PUBMED 2994220 REFERENCE 9 (sites) AUTHORS Allan,J.S., Coligan,J.E., Lee,T.H., McLane,M.F., Kanki,P.J., Groopman,J.E. and Essex,M. TITLE A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients JOURNAL Science 230 (4727), 810-813 (1985) PUBMED 2997921 REFERENCE 10 (sites) AUTHORS Rosen,C.A., Sodroski,J.G., Goh,W.C., Dayton,A.I., Lippke,J. and Haseltine,W.A. TITLE Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III JOURNAL Nature 319 (6054), 555-559 (1986) PUBMED 3003584 REFERENCE 11 (sites) AUTHORS di Marzo Veronese,F., Copeland,T.D., DeVico,A.L., Rahman,R., Oroszlan,S., Gallo,R.C. and Sarngadharan,M.G. TITLE Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV JOURNAL Science 231 (4743), 1289-1291 (1986) PUBMED 2418504 REFERENCE 12 (sites) AUTHORS Kramer,R.A., Schaber,M.D., Skalka,A.M., Ganguly,K., Wong-Staal,F. and Reddy,E.P. TITLE HTLV-III gag protein is processed in yeast cells by the virus pol-protease JOURNAL Science 231 (4745), 1580-1584 (1986) PUBMED 2420008 REFERENCE 13 (sites) AUTHORS Dayton,A.I., Sodroski,J.G., Rosen,C.A., Goh,W.C. and Haseltine,W.A. TITLE The trans-activator gene of the human T cell lymphotropic virus type III is required for replication JOURNAL Cell 44 (6), 941-947 (1986) PUBMED 2420471 REFERENCE 14 (sites) AUTHORS Lee,T.H., Coligan,J.E., Allan,J.S., McLane,M.F., Groopman,J.E. and Essex,M. TITLE A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses JOURNAL Science 231 (4745), 1546-1549 (1986) PUBMED 3006243 REFERENCE 15 (sites) AUTHORS Sodroski,J., Goh,W.C., Rosen,C., Tartar,A., Portetelle,D., Burny,A. and Haseltine,W. TITLE Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions JOURNAL Science 231 (4745), 1549-1553 (1986) PUBMED 3006244 REFERENCE 16 (sites) AUTHORS Kan,N.C., Franchini,G., Wong-Staal,F., DuBois,G.C., Robey,W.G., Lautenberger,J.A. and Papas,T.S. TITLE Identification of HTLV-III/LAV sor gene product and detection of antibodies in human sera JOURNAL Science 231 (4745), 1553-1555 (1986) PUBMED 3006245 REFERENCE 17 (sites) AUTHORS Arya,S.K. and Gallo,R.C. TITLE Three novel genes of human T-lymphotropic virus type III: immune reactivity of their products with sera from acquired immune deficiency syndrome patients JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (7), 2209-2213 (1986) PUBMED 3008154 REFERENCE 18 (sites) AUTHORS Jones,K.A., Kadonaga,J.T., Luciw,P.A. and Tjian,R. TITLE Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1 JOURNAL Science 232 (4751), 755-759 (1986) PUBMED 3008338 REFERENCE 19 (sites) AUTHORS Sodroski,J., Goh,W.C., Rosen,C., Dayton,A., Terwilliger,E. and Haseltine,W. TITLE A second post-transcriptional trans-activator gene required for HTLV-III replication JOURNAL Nature 321 (6068), 412-417 (1986) PUBMED 3012355 REFERENCE 20 (sites) AUTHORS Starcich,B.R., Hahn,B.H., Shaw,G.M., McNeely,P.D., Modrow,S., Wolf,H., Parks,E.S., Parks,W.P., Josephs,S.F., Gallo,R.C. and Wong-Staal,F. TITLE Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS JOURNAL Cell 45 (5), 637-648 (1986) PUBMED 2423250 REFERENCE 21 (sites) AUTHORS Willey,R.L., Rutledge,R.A., Dias,S., Folks,T., Theodore,T., Buckler,C.E. and Martin,M.A. TITLE Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirus JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83 (14), 5038-5042 (1986) PUBMED 3014529 REFERENCE 22 (bases 8761 to 9060) AUTHORS Fisher,A.G., Ratner,L., Mitsuya,H., Marselle,L.M., Harper,M.E., Broder,S., Gallo,R.C. and Wong-Staal,F. TITLE Infectious mutants of HTLV-III with changes in the 3' region and markedly reduced cytopathic effects JOURNAL Science 233 (4764), 655-659 (1986) PUBMED 3014663 REFERENCE 23 (sites) AUTHORS Feinberg,M.B., Jarrett,R.F., Aldovini,A., Gallo,R.C. and Wong-Staal,F. TITLE HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA JOURNAL Cell 46 (6), 807-817 (1986) PUBMED 3638988 REFERENCE 24 (sites) AUTHORS Lightfoote,M.M., Coligan,J.E., Folks,T.M., Fauci,A.S., Martin,M.A. and Venkatesan,S. TITLE Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus JOURNAL J. Virol. 60 (2), 771-775 (1986) PUBMED 2430111 REFERENCE 25 (sites) AUTHORS Terwilliger,E., Sodroski,J.G., Rosen,C.A. and Haseltine,W.A. TITLE Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity JOURNAL J. Virol. 60 (2), 754-760 (1986) PUBMED 3490583 REFERENCE 26 (sites) AUTHORS Wright,C.M., Felber,B.K., Paskalis,H. and Pavlakis,G.N. TITLE Expression and characterization of the trans-activator of HTLV-III/LAV virus JOURNAL Science 234 (4779), 988-992 (1986) PUBMED 3490693 REFERENCE 27 (sites) AUTHORS Patarca,R., Heath,C., Goldenberg,G.J., Rosen,C.A., Sodroski,J.G., Haseltine,W.A. and Hansen,U.M. TITLE Transcription directed by the HIV long terminal repeat in vitro JOURNAL AIDS Res. Hum. Retroviruses 3 (1), 41-55 (1987) PUBMED 3040054 REFERENCE 28 (bases 1 to 9635) AUTHORS Ratner,L., Fisher,A., Jagodzinski,L.L., Mitsuya,H., Liou,R.S., Gallo,R.C. and Wong-Staal,F. TITLE Complete nucleotide sequences of functional clones of the AIDS virus JOURNAL AIDS Res. Hum. Retroviruses 3 (1), 57-69 (1987) PUBMED 3040055 REFERENCE 29 (sites) AUTHORS Wong-Staal,F., Chanda,P.K. and Ghrayeb,J. TITLE Human immunodeficiency virus: the eighth gene JOURNAL AIDS Res. Hum. Retroviruses 3 (1), 33-39 (1987) PUBMED 3476127 REFERENCE 30 (sites) AUTHORS Modrow,S., Hahn,B.H., Shaw,G.M., Gallo,R.C., Wong-Staal,F. and Wolf,H. TITLE Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions JOURNAL J. Virol. 61 (2), 570-578 (1987) PUBMED 2433466 REFERENCE 31 (sites) AUTHORS Goh,W.C., Sodroski,J.G., Rosen,C.A. and Haseltine,W.A. TITLE Expression of the art gene protein of human T-lymphotropic virus type III (HTLV-III/LAV) in bacteria JOURNAL J. Virol. 61 (2), 633-637 (1987) PUBMED 3543401 REFERENCE 32 (sites) AUTHORS Muesing,M.A., Smith,D.H. and Capon,D.J. TITLE Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein JOURNAL Cell 48 (4), 691-701 (1987) PUBMED 3643816 REFERENCE 33 (sites) AUTHORS Nabel,G. and Baltimore,D. TITLE An inducible transcription factor activates expression of human immunodeficiency virus in T cells JOURNAL Nature 326 (6114), 711-713 (1987) PUBMED 3031512 REMARK Erratum:[Nature 1990 Mar 8;344(6262):178] REFERENCE 34 (sites) AUTHORS Fisher,A.G., Ensoli,B., Ivanoff,L., Chamberlain,M., Petteway,S., Ratner,L., Gallo,R.C. and Wong-Staal,F. TITLE The sor gene of HIV-1 is required for efficient virus transmission in vitro JOURNAL Science 237 (4817), 888-893 (1987) PUBMED 3497453 REFERENCE 35 (bases 6225 to 8795) AUTHORS Reitz,M.S. Jr., Wilson,C., Naugle,C., Gallo,R.C. and Robert-Guroff,M. TITLE Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene JOURNAL Cell 54 (1), 57-63 (1988) PUBMED 2838179 REFERENCE 36 (bases 790 to 2292) AUTHORS Pal,R., Reitz,M.S. Jr., Tschachler,E., Gallo,R.C., Sarngadharan,M.G. and Veronese,F.D. TITLE Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly JOURNAL AIDS Res. Hum. Retroviruses 6 (6), 721-730 (1990) PUBMED 2194551 REFERENCE 37 (sites) AUTHORS Ido,E., Han,H.P., Kezdy,F.J. and Tang,J. TITLE Kinetic studies of human immunodeficiency virus type 1 protease and its active-site hydrogen bond mutant A28S JOURNAL J. Biol. Chem. 266 (36), 24359-24366 (1991) PUBMED 1761538 COMMENT On Mar 25, 1997 this sequence version replaced gi:327742. [6] sites; tat mRNA and other transcript boundaries. [7] sites; tat mRNA. [8] sites; mRNA splice sites. [9] sites; 27K antigen cds. [5] sites; gp160 and gp120 coding sequences. [1] sites; regulatory sequences in the LTR. [(in) Weiss,R., Teich,N., Varmus,H. and Coffin,J. (Eds.);RNA Tumor Viruses, Secon] review; bases 1 to 9718. [15] sites; trans-activator function and TAR sequence. [19] sites; pol coding sequence. [22] sites; 23K sor gene product. [23] sites; pol NH2-terminal region. [20] sites; sor 23K protein. [21] sites; sor 23K protein. [24] sites; Sp1 binding sites in the promoter region. [17] sites; acceptor and donor splice sites for tat and 27K. [10] sites; deletion mutants in the tat gene. [18] sites; env gene conserved/varable regions; separate entries. [16] sites; trs cds boundaries. [12] sites; trs cds boundaries. [11] sites; env gene conserved/variable regions; separate entries. [26] sites; tar or transactivator target. [13] sites; 3' orf mutations. [14] sites; pol p34 terminus. [31] sites; promoter, TAR, tat-III mutants. [32] sites; envelope protein epitopes. [33] sites; trs/art protein. [34] sites; inducible enhancer element. [27] revises [30]. [29] sites; long terminal repeat. [28] sites; R orf. [35] sites; sor. Sequence for [25] kindly provided in computer-readable form by L.Ratner, 19-AUG-1986. The HXB2 sequence is being used as a reference genome for all the HIV entries because it has been derived from a demonstrably infectious clone. Hence not all of the 'sites' references above were concerned with this isolate. FEATURES Qualifiers source /organism="Human immunodeficiency virus 1" /proviral /mol_type="genomic RNA" /isolate="HXB2" /db_xref="taxon:11676" /note="HTLV-III/LAV" protein /note="trs protein" intron_pos 26:1 (1/1) BEGIN 1 MAGRSGDSDE ELIRTVRLIK LLYQSNPPPN PEGTRQARRN RRRRWRERQR QIHSISERIL 61 GTYLGRSAEP VPLQLPPLER LTLDCNEDCG TSGTQGVGSP QILVESPTVL ESGTKE //