LOCUS       AAA60331.1               693 aa    PRT              HUM 11-JAN-1995
DEFINITION  Homo sapiens guanosine 5'-monophosphate synthetase protein.
ACCESSION   U10860-1
PROTEIN_ID  AAA60331.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2212)
  AUTHORS   Hirst,M., Haliday,E., Nakamura,J. and Lou,L.
  TITLE     Human GMP synthetase. Protein purification, cloning, and functional
            expression of cDNA
  JOURNAL   J. Biol. Chem. 269 (38), 23830-23837 (1994)
   PUBMED   8089153
REFERENCE   2  (bases 1 to 2212)
  AUTHORS   Lou,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-JUN-1994) Lillian Lou, Syntex Discovery Research,
            3401 Hillview Avenue, Mail Stop S3-1, Palo Alto, CA 94303, USA
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000218016"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="GMPS.6"
                     /cell_line="A3.01"
                     /cell_type="T-lymphoblastoma"
                     /clone_lib="Strategene Lambda-ZAP-II"
                     /note="custom cDNA library made by Stratagene (La Jolla,
                     CA) using poly(A)+ RNA from A3.01 cells, catalog number
                     836201"
     protein         /EC_number="6.3.5.2"
                     /function="de novo synthesis of GMP"
                     /standard_name="GMP synthase"
                     /note="located in the cytosol; a glutamine
                     amidotransferase (G-type)"
BEGIN
        1 MALCNGDSKL ENAGGDLKDG HHHYEGAVVI LDAGAQYGKV IDRRVRELFV QSEIFPLETP
       61 AFAIKEQGFR AIIISGGPNS VYAEDAPWFD PAIFTIGKPV LGICYGMQMM NKVFGGTVHK
      121 KSVREDGVFN ISVDNTCSLF RGLQKEEVVL LTHGDSVDKV ADGFKVVARS GNIVAGIANE
      181 SKKLYGAQFH PEVGLTENGK VILKNFLYDI AGCSGTFTVQ NRELECIREI KERVGTSKVL
      241 VLLSGGVDST VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA
      301 HSFYNGTTTL PISDEDRTPR KRISKTLNMT TSPEEKRKII GDTFVKIANE VIGEMNLKPE
      361 EVFLAQGTLR PDLIESASLV ASGKAELIKT HHNDTELIRK LREEGKVIEP LKDFHKDEVR
      421 ILGRELGLPE ELVSRHPFPG PGLAIRVICA EEPYICKDFP ETNNILKIVA DFSASVKKPH
      481 TLLQRVKACT TEEDQEKLMQ ITSLHSLNAF LLPIKTVGVQ GDCRSYSYVC GISSKDEPDW
      541 ESLIFLARLI PRMCHNVNRV VYIFGPPVKE PPTDVTPTFL TTGVLSTLRQ ADFEAHNILR
      601 ESGYAGKISQ MPVILTPLHF DRDPLQKQPS CQRSVVIRTF ITSDFMTGIP ATPGNEIPVE
      661 VVLKMVTEIK KIPGISRIMY DLTSKPPGTT EWE
//