LOCUS CAB13589.3 5043 aa PRT BCT 08-FEB-2018
DEFINITION Bacillus subtilis subsp. subtilis str. 168 polyketide
synthase of type I involved in nonribosomal synthesis
of bacillaene protein.
ACCESSION AL009126-1794
PROTEIN_ID CAB13589.3
SOURCE Bacillus subtilis subsp. subtilis str. 168
ORGANISM Bacillus subtilis subsp. subtilis str. 168
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE 1 (bases 1 to 4215606)
AUTHORS Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G.,
Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S.,
Borriss R., Boursier L., Brans A., Braun M., Brignell S.C.,
Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V.,
Carter N.M., Choi S.K., Codani J.J., Connerton I.F., Cummings N.J.,
Daniel R.A., Denizot F., Devine K.M., Dusterhoft A., Ehrlich S.D.,
Emmerson P.T., Entian K.D., Errington J., Fabret C., Ferrari E.,
Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A.,
Galleron N., Ghim S.Y., Glaser P., Goffeau A., Golightly E.J.,
Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R.,
Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.F.,
Itaya M., Jones L., Joris B., Karamata D., Kasahara Y.,
Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P.,
Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A.,
Lardinois S., Lauber J., Lazarevic V., Lee S.M., Levine A., Liu H.,
Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P.,
Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M.,
Ogawa K., Ogiwara A., Oudega B., Park S.H., Parro V., Pohl T.M.,
Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P.,
Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M.,
Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T.,
Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
Sekowska A., Seror S.J., Serror P., Shin B.S., Soldo B.,
Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K.,
Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A.,
Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A.,
Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T.,
Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K.,
Yoshida K., Yoshikawa H.F., Zumstein E., Yoshikawa H., Danchin A.
TITLE The complete genome sequence of the gram-positive bacterium
Bacillus subtilis
JOURNAL Nature 390(6657), 249-256(1997).
PUBMED 9384377
REFERENCE 2 (bases 1 to 4215606)
AUTHORS Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G.,
Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C.,
Danchin A.
TITLE From a consortium sequence to a unified sequence: the Bacillus
subtilis 168 reference genome a decade later
JOURNAL Microbiology (Reading, Engl.) 155(Pt 6), 1758-1775(2009).
PUBMED 19383706
REFERENCE 3 (bases 1 to 4215606)
AUTHORS Belda E., Sekowska A., Le Fevre F., Mornico D., Morgat A.,
Ouzounis C., Vallenet D., Medigue C., Danchin A.
TITLE An updated metabolic view of the Bacillus subtilis 168 genome
JOURNAL Microbiology (Reading, Engl.) 159(Pt 4), 757-770(2013).
PUBMED 23429746
REFERENCE 4 (bases 1 to 4215606)
AUTHORS Kunst F., Ogasawara N., Yoshikawa H., Danchin A.
JOURNAL Submitted (18-NOV-1997) to the INSDC. I. Moszer, A. Danchin,
Genetique des Genomes Bacteriens, Institut Pasteur, 28 rue du
Docteur Roux, 75724 Paris Cedex 15, FRANCE. E-mail:
moszer@pasteur.fr, antoine.danchin@normalesup.org Phone: +33 (0)1
45 68 84 41, Fax: +33 (0)1 45 68 89 48
REFERENCE 5 (bases 1 to 4215606)
AUTHORS Genoscope - C.E.A.
CONSRTM Institut Pasteur and Genoscope
JOURNAL Submitted (29-JAN-2009) to the INSDC. Genoscope - Centre National
de Sequencage : BP 191 91006 EVRY cedex - FRANCE (E-mail :
seqref@genoscope.cns.fr - Web : www.genoscope.cns.fr)
REFERENCE 6 (bases 1 to 4215606)
AUTHORS Genoscope - C.E.A.
CONSRTM AMAbiotics and Genoscope
JOURNAL Submitted (24-JAN-2013) to the INSDC. A. Danchin, AMAbiotics, Bldg
G1, 2, rue Gaston Cremieux, 91000 EVRY
antoine.danchin@normalesup.org Bldg G1 Genoscope / CEA
(Commissariat a l'energie atomique et aux energies alternatives):
BP 191 91006 EVRY cedex - FRANCE (E-mail: seqref@genoscope.cns.fr -
Web: www.genoscope.cns.fr)
REFERENCE 8
AUTHORS Borriss R., Danchin A., Harwood C.R., Medigue C., Rocha E.P.C.,
Sekowska A., Vallenet D.
TITLE Bacillus subtilis, the model Gram-positive bacterium: 20 years of
annotation refinement
JOURNAL Microb Biotechnol 11(1), 3-17(2018).
PUBMED 29280348
COMMENT On or before Mar 17, 2009 this sequence version replaced
gi:32468687, gi:32468690, gi:32468695, gi:32468704, gi:32468715,
gi:32468723, gi:32468738, gi:32468743, gi:32468745, gi:32468758,
gi:32468767, gi:32468778, gi:32468787, gi:32468796, gi:32468802,
gi:32468809, gi:32468813, gi:32468825, gi:32468830, gi:32468833,
gi:32468840, gi:38680335.
Annotation results relative to BLAST similarities, COG
assignations, enzymatic function prediction (PRIAM software), TMHMM
and SignalP predictions, and synteny conservation (Syntonizer
software) are available in the MicroScope annotation platform
http://www.genoscope.cns.fr/agc/microscope.
The large cluster comprising the i, h and g rDNA regions could not
be properly resolved, we therefore incorporated the original
sequence of rRNAihg in the final assembly.
FEATURES Qualifiers
source /organism="Bacillus subtilis subsp. subtilis str. 168"
/sub_species="subtilis"
/strain="168"
/mol_type="genomic DNA"
/db_xref="taxon:224308"
protein /transl_table=11
/gene="pksJ"
/locus_tag="BSU_17180"
/old_locus_tag="BSU17180"
/function="16.5: Explore"
/function="16.8: Protect"
/note="Evidence 1c: Function from experimental evidences
in the studied genus; PubMedId: 16707694, 17234808,
17827323, 26284661, 26268540; Product type e: enzyme"
/db_xref="EnsemblGenomes-Gn:BSU17180"
/db_xref="EnsemblGenomes-Tr:CAB13589"
/db_xref="GOA:P40806"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR010071"
/db_xref="InterPro:IPR013968"
/db_xref="InterPro:IPR014030"
/db_xref="InterPro:IPR014031"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR018201"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020807"
/db_xref="InterPro:IPR020841"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR032821"
/db_xref="InterPro:IPR036291"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042099"
/db_xref="InterPro:IPR042104"
/db_xref="PDB:4J1Q"
/db_xref="PDB:4J1S"
/db_xref="PDB:4NA1"
/db_xref="PDB:4NA2"
/db_xref="PDB:4NA3"
/db_xref="PDB:5KTK"
/db_xref="SubtiList:BG10929"
/db_xref="UniProtKB/Swiss-Prot:P40806"
/inference="ab initio prediction:AMIGene:2.0"
BEGIN
1 MRNNDNIRIL TNPSVSHGEP LHISEKQPAT IPEVLYRTAT ELGDTKGIIY LQPDGTEVYQ
61 SYRRLWDDGL RIAKGLRQSG LKAKQSVILQ LGDNSQLLPA FWGCVLTGVV PAPLAVPPTY
121 AESSSGTQKL KDAWTLLDKP AVITDRGMHQ EMLDWAKEQG LEGFRAIIVE DLLSAEADTD
181 WHQSSPEDLA LLLLTSGSTG TPKAVMLNHR NIMSMVKGII QMQGFTREDI TFNWMPFDHV
241 GGIGMLHLRD VYLGCQEINV SSETILMEPL KWLDWIDHYR ASVTWAPNFA FGLVTDFAEE
301 IKDKKWDLSS MRYMLNGGEA MVAKVGRRIL ELLEPHGLPA DAIRPAWGMS ETSSGVIFSH
361 EFTRAGTSDD DHFVEIGSPI PGFSMRIVND HNELVEEGEI GRFQVSGLSV TSGYYQRPDL
421 NESVFTEDGW FETGDLGFLR NGRLTITGRT KDAIIINGIN YYSHAIESAV EELPEIETSY
481 TAACAVRLGQ NSTDQLAIFF VTSAKLNDEQ MSQLLRNIQS HVSQVIGVTP EYLLPVQKEE
541 IPKTAIGKIQ RTQLKTSFEN GEFDHLLHKP NRMNDAVQDE GIQQADQVKR VREEIQKHLL
601 TCLTEELHVS HDWVEPNANI QSLGVNSIKM MKLIRSIEKN YHIKLTAREI HQYPTIERLA
661 SYLSEHEDLS SLSADKKGTD TYKTEPERSQ ATFQPLSEVQ KGLWTLQKMS PEKSAYHVPL
721 CFKFSSGLHH ETFQQAFGLV LNQHPILKHV IQEKDGVPFL KNEPALSIEI KTENISSLKE
781 SDIPAFLRKK VKEPYVKENS PLVRVMSFSR SEQEHFLLVV IHHLIFDGVS SVTFIRSLFD
841 TYQLLLKGQQ PEKAVSPAIY HDFAAWEKNM LAGKDGVKHR TYWQKQLSGT LPNLQLPNVS
901 ASSVDSQFRE DTYTRRLSSG FMNQVRTFAK EHSVNVTTVF LSCYMMLLGR YTGQKEQIVG
961 MPAMVRPEER FDDAIGHFLN MLPIRSELNP ADTFSSFISK LQLTILDGLD HAAYPFPKMV
1021 RDLNIPRSQA GSPVFQTAFF YQNFLQSGSY QSLLSRYADF FSVDFVEYIH QEGEYELVFE
1081 LWETEEKMEL NIKYNTGLFD AASISAMFDH FVYVTEQAML NPSQPLKEYS LLPEAEKQMI
1141 LKTWNATGKT YPYITFHELF EQQAKKTPDR AAVSYEGQTL TYRELDEKST QLAIYLQAHG
1201 VGPDRLAGIY VDRSLDMLVG LLAILKAGGA YVPLDPSYPA ERLEYMLEDS EVFITLTTSE
1261 LVNTLSWNGV TTALLDQDWD EIAQTASDRK VLTRTVTPEN LAYVIYTSGS TGKPKGVMIP
1321 HKALTNFLVS MGETPGLTAE DKMLAVTTYC FDIAALELFL PLIKGAHCYI CQTEHTKDVE
1381 KLKRDIRAIK PTVMQATPAT WKMLFYSGWE NEESVKILCG GEALPETLKR YFLDTGSEAW
1441 NMFGPTETTI WSAVQRINVE CSHATIGRPI ANTQIYITDS QLAPVPAGVP GELCIAGDGV
1501 AKGYYKKEEL TDSRFIDNPF EPGSKLYRTG DMARWLTGGR IEYIGRIDNQ VKIRGFRIEL
1561 GDIESRLSEH PGILECVVVA DMDNLAAYYT AKHANASLTA RELRHFVKNA LPAYMVPSYF
1621 IQLDHMPLTP NGKIDRNSLK NIDLSGEQLK QRQTSPKNIQ DTVFTIWQEV LKTSDIEWDD
1681 GFFDVGGDSL LAVTVADRIK HELSCEFSVT DLFEYSTIKN ISQYITEQRM GDASDHIPTD
1741 PAAHIEDQST EMSDLPDYYD DSVAIIGISC EFPGAKNHDE FWENLRDGKE SIAFFNKEEL
1801 QRFGISKEIA ENADYVPAKA SIDGKDRFDP SFFQISPKDA EFMDPQLRML LTHSWKAIED
1861 AGYAARQIPQ TSVFMSASNN SYRALLPSDT TESLETPDGY VSWVLAQSGT IPTMISHKLG
1921 LRGPSYFVHA NCSSSLIGLH SAYKSLLSGE SDYALVGGAT LHTESNIGYV HQPGLNFSSD
1981 GHIKAFDASA DGMIGGEGVA VVLLKKAADA VKDGDHIYAL LRGIGVNNDG ADKVGFYAPS
2041 VKGQADVVQQ VMNQTKVQPE SICYVEAHGT GTKLGDPIEL AALTNVYRQY TNKTQFCGIG
2101 SVKTNIGHLD TAAGLAGCIK VVMSLYHQEL APSVNYKEPN PNTDLASSPF YVVDQKKTLS
2161 REIKTHRAAL SSFGLGGTNT HAIFEQFKRD SDKGKIDGTC IVPISAKNKE RLQEYAEDIL
2221 AYLERRGFEN SQLPDFAYTL QVGREAMEHR VVFIADHVNE LKQRLTDFIN GNTAIEGCFQ
2281 GSKHNAREVS WLTEDEDSAE LIRKWMAKGK VNKLAEMWSK GAHIDWMQLY KGERPNRMSL
2341 PTYPFAKERY WPSQDDRKPV AQISGNQTGI GSIHPLLHQN TSDFSEQKFS SVFTGDEFFL
2401 RDHVVRGKPV LPGVAYLEMA YAAINQAAGS EIGQDVRIRL NHTVWVQPVV VDRHSAQVDI
2461 SLFPEEDGKI TFDIYSTQED GDDPVIHSQG SAELASAAET PVADLTEMSR RCGKGKMSPD
2521 QFYEEGRSRG MFHGPAFQGI KNVNIGNREV LAQLQLPEIV SGTNEQFVLH PSIMDSALQT
2581 ATICIMQELT DQKLILPFAL EELEVIKGCS SSMWAYARLS DSDHSGGVVQ KADIDVIDES
2641 GTVCVRIKGF STRVLEGEVH TSKPSTRHER LMLEPVWEKQ NEEREDEDLS YTEHIIVLFE
2701 TERSVTDSIA SHMKDARVIT LNEAVGHIAE RYQCYMQNIF ELLQSKVRKL SAGRIIIQAI
2761 VPLEKEKQLF AGVSGLFKTA EIEFSKLTAQ VIEIEKPEEM IDLHLKLKDD SRRPFDKQIR
2821 YEAGYRFVKG WREMVLPSAD TLHMPWRDEG VYLITGGAGS LGLLFAKEIA NRTGRSTIVL
2881 TGRSVLSEDK ENELEALRSI GAEVVYREAD VSDQHAVRHL LEEIKERYGT LNGIIHGAGS
2941 SKDRFIIHKT NEEFQEVLQP KVSGLLHVDE CSKDFPLDFF IFFSSVSGCL GNAGQADYAA
3001 ANSFMDAFAE YRRSLAASKK RFGSTISFNW PLWEEGGMQV GAEDEKRMLK TTGMVPMPTD
3061 SGLKAFYQGI VSDKPQVFVM EGQLQKMKQK LLSAGSKAKR NDQRKADQDQ GQTRKLEAAL
3121 IQMVGAILKV NTDDIDVNTE LSEYGFDSVT FTVFTNKINE KFQLELTPTI FFEYGSVQSL
3181 AEYVVAAYQG EWNQDATAKG KDERTNLVHS LSSLEASLSN MVSAILKVNS EDIDVNTELS
3241 EYGFDSVTFT VFTNKINEEF QLELTPTIFF EYGSLHSLAE YLTVEHGDTL VQEREKPEGQ
3301 EELQTKSSEA PKITSRRKRR FTQPIIAKAE RNKKQAADFE PVAIVGISGR FPGAMDIDEF
3361 WKNLEEGKDS ITEVPKDRWD WREHYGNPDT DVNKTDIKWG GFIDGVAEFD PLFFGISPRE
3421 ADYVDPQQRL LMTYVWKALE DAGCSPQSLS GTGTGIFIGT GNTGYKDLFH RANLPIEGHA
3481 ATGHMIPSVG PNRMSYFLNI HGPSEPVETA CSSSLVAIHR AVTAMQNGDC EMAIAGGVNT
3541 ILTEEAHISY SKAGMLSTDG RCKTFSADAN GYVRGEGVGM VMLKKLEDAE RDGNHIYGVI
3601 RGTAENHGGR ANTLTSPNPK AQADLLVRAY RQADIDPSTV TYIEAHGTGT ELGDPIEING
3661 LKAAFKELSN MRGESQPDVP DHRCGIGSVK SNIGHLELAA GISGLIKVLL QMKHKTLVKS
3721 LHCETLNPYL QLTDSPFYIV QEKQEWKSVT DRDGNELPRR AGISSFGIGG VNAHIVIEEY
3781 MPKANSEHTA TEQPNVIVLS AKNKSRLIDR ASQLLEVIRN KKYTDQDLHR IAYTLQVGRE
3841 EMDERLACVA GTMQELEEKL QAFVDGKEET DEFFRGQSHR NKETQTIFTA DEDMALALDA
3901 WIRKRKYAKL ADLWVKGVSI QWNTLYGETK PRLISLPSYP FAKDHYWVPA KEHSERDKKE
3961 LVNAIEDRAA CFLTKQWSLS PIGSAVPGTR TVAILCCQET ADLAAEVSSY FPNHLLIDVS
4021 RIENDQSDID WKEFDGLVDV IGCGWDDEGR LDWIEWVQRL VEFGHKEGLR LLCVTKGLES
4081 FQNTSVRMAG ASRAGLYRML QCEYSHLISR HMDAEEVTDH RRLAKLIADE FYSDSYDAEV
4141 CYRDGLRYQA FLKAHPETGK ATEQSAVFPK DHVLLITGGT RGIGLLCARH FAECYGVKKL
4201 VLTGREQLPP REEWARFKTS NTSLAEKIQA VRELEAKGVQ VEMLSLTLSD DAQVEQTLQH
4261 IKRTLGPIGG VIHCAGLTDM DTLAFIRKTS DDIQRVLEPK VSGLTTLYRH VCNEPLQFFV
4321 LFSSVSAIIP ELSAGQADYA MANSYMDYFA EAHQKHAPII SVQWPNWKET GMGEVTNQAY
4381 RDSGLLSITN SEGLRFLDQI VSKKFGPVVL PAMANQTNWE PELLMKRRKP HEGGLQEAAL
4441 QSPPARDIEE ADEVSKCDGL LSETQSWLID LFTEELRIDR EDFEIDGLFQ DYGVDSIILA
4501 QVLQRINRKL EAALDPSILY EYPTIQRFAD WLIGSYSERL SALFGGRISD ASAPLENKIE
4561 AEASVPGKDR ALTPQIQAPA ILSPDSHAEG IAVVGLSCRF PGAETLESYW SLLSEGRSSI
4621 GPIPAERWGC KTPYYAGVID GVSYFDPDFF LLHEEDVRAM DPQALLVLEE CLKLLYHAGY
4681 TPEEIKGKPV GVYIGGRSQH KPDEDSLDHA KNPIVTVGQN YLAANLSQFF DVRGPSVVVD
4741 TACSSALVGM NMAIQALRGG DIQSAIVGGV SLLSSDASHR LFDRRGILSK HSSFHVFDER
4801 ADGVVLGEGV GMVMLKTVKQ ALEDGDIIYA VVKAASVNND GRTAGPATPN LEAQKEVMKD
4861 ALFKSGKKPE DISYLEANGS GSIVTDLLEL KAIQSVYRSG HSSPLSLGSI KPNIGHPLCA
4921 EGIASFIKVV LMLKERRFVP FLSGEKEMAH FDQQKANITF SRALEKWTDS QPTAAINCFA
4981 DGGTNAHVIV EAWEKDEKHA IKRSPISPPQ LKKRMLSPGE PKLEAETSKM TAANIWDTYE
5041 VEV
//