LOCUS BAC69262.1 4809 aa PRT BCT 07-OCT-2016
DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 putative
modular polyketide synthase protein.
ACCESSION BA000030-1560
PROTEIN_ID BAC69262.1
SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893
ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
Streptomycetaceae; Streptomyces.
REFERENCE 1 (bases 1 to 9025608)
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
Contact:S Omura
Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
Kitasato, Sagamihara, Kanagawa 228-8555, Japan
URL :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE 2
AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
TITLE Complete Genome Sequence and Comparative Analysis of the
Industrial Microorganism Streptomyces avermitilis
JOURNAL Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE 3
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Genome sequence of an industrial microorganism Streptomyces
avermitilis: Deducing the ability of producing secondary
metabolites
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE 4
AUTHORS Ikeda,H., Shin-ya,K. and Omura,S.
TITLE Genome mining of the Streptomyces avermitilis genome and
development of genome-minimized hosts for heterologous expression
of biosynthetic gene clusters
JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT This work was done in collaboration with Haruo Ikeda(*1),
Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
Hattori(*1,*7)
and Satoshi Omura(*1,*3).
Final finishing process and all annotation were done by H. Ikeda
and J. Ishikawa.
*1 Kitasato Institute for Life Sciences, Kitasato University
*2 National Institute of Infectious Diseases
*3 The Kitasato Institute
*4 National Institute of Technology and Evaluation
*5 School of Science, Kitasato University
*6 Institute of Medical Science, University of Tokyo
*7 RIKEN, Genomic Sciences Center
All the annotated genes identified are available from following
urls.
http://avermitilis.ls.kitasato-u.ac.jp
FEATURES Qualifiers
source /db_xref="taxon:227882"
/mol_type="genomic DNA"
/note="This strain is also named as strain: ATCC 31267,
NCIMB 12804 or NRRL 8165."
/organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
/strain="MA-4680"
protein /gene="pks2-2"
/locus_tag="SAVERM_1551"
/old_locus_tag="SAV_1551"
/transl_table=11
BEGIN
1 MRAWLSAAVA DAAGLQAPVI DLDRPIAEFG LSSRQLVTLA AELSQRIDRP LNPSLVFDHP
61 TIAGIAEAVF DESPVGATAA DPAPADAPPA RADDDIAIVS MACRFPGGAD DPEALWRLLT
121 AGEDAISEVP AGRWDTQGLY DPDPEATGKA YTLRGGFLSD IDRFDASFFG ISPREAAAMD
181 PQQRLLLGTA WETIERAGIV PETLNGSSTG VYIGLYDSGY QASASLGRLD GHVGTGSASS
241 VASGRISYTL GLQGPAVTVD TACSSSLVAL HLAARALADG ECDLALTGGA TLLVTPRGHV
301 EFSRLRGLSP SGRCSPFSTE ADGVVWAEGC GLVLLKRLAD ARRDGDRVLA VVKGSAINQD
361 GRSQGLSAPS GPAQERVLRA ALDAAGLRPD DLDYVEAHGT GTPLGDPIEG RALTAVFGPG
421 RPADRPLGVG SLKSNLGHTQ AAAGIGGVIK TVLALGHQLL PASLHAETPT EHIDWAGGGL
481 RVHSTAAGWP RDVDRVRRAG VSAFGISGTN AHVVLEEAPH DLTRPTGEPQ SPEQPTAEET
541 APHLPAPHLP APHLTGKTLF PLSARTLPAL RGQAGRLLEA LSADPQTPLP EAAATLAHHR
601 THFEHRAVVQ AGDRDELLTA LRGLAEGQPD TDRVAGPQQA LPPGKLAFVF PGQGAQWTGM
661 ARDLLDRSPV FADELDRCDA ALRPFTTWSV AAVLRGDAGA PSPDRVDVVQ PVLFAVMMSL
721 AAVWRARGVR PDAVIGHSQG EVAAACVAGA LSLNDAAAVV ALRSQALTEL SGTGAMAVVA
781 LPHTEVEAHL AGLDGRVSVA AVNSGRSTVI AGDVEPLEAL LADLDRQQVF VRRLDVDYAS
841 HSAQVEQVRA AVLDELDGIT TCPTSVAWYS TVLGEPVTEE LEADYWYTNL REPVRFAPTV
901 ERMAADGYRY FVELSPHPSL LTALRTVVED ADAAEAAEDT APDLVAVGSL RRDEDGPACL
961 DRAAAELHVH GRRIDWRRLV ADAPRADLPT YAWDPQRHWI EPEAAAGAPG LFDRAAHPLL
1021 GIQLQSADET RWTFRNEWSP ATADWLPDHA VFGRTVVSGT TLMELCRAAL AVARPDAPGD
1081 VTDLFLLTPL TLPGSGTVEV SVEVVTAGPV PEITVHSRPR GQEGTGWTLH ATASAAEAAP
1141 VTQGPLPVWP EAAGTAWSPK TYERLARLGL GYGPAFQGVR AAVTTGDGEL LARLSLPTVA
1201 RDVADPYPLH PAVLDAALHV AAVFDAGDAS DGRVLLPVAV GRCVLPHGGA TELTARVRRS
1261 GGSGTDLTLD VTLWDADGIP AGRLEGVRLR AANPADLGTG SENGRHLYEV AWTAVPEEPA
1321 GAPGTEWTVL GDPSDPEAAA ALRGLAAAGI TVGETGADVR VRFWPRPASD VEPAAAAQEL
1381 AATALAELQA LLALPEDEAP TRTVWVTHGA VAAGEGDTVP GLAQSVLWGL ARSARTEHPG
1441 LGLTLLDLDG SDPGGALPVA VAYAGEPELA LRAGTLLVPR LVRARAAQAL PIPADDHYEL
1501 AGLPADVTLR AVAPRALAPG QVRIQVHAAR VHPSGDDAPD AVSAGVLTEV GADVEGLALG
1561 LRVVAVADTA PGSAAVADAR LVVALPDGLP FTTAVTLPGE HADAVAPGRA ELGAALREAV
1621 ASVAAGHTRP TRPRAWPVTA AREAIRRGGP VVLDLVGRPT LAPTDGTVLI TGGLGAVGRH
1681 IARLLAEHGV PRLLLTSRQG ADDPRAAEVR AELAALGAEV EVAACDVADA AALADVLGRI
1741 GDELPLRGVV HCAGVLADGV VAELTPERLT RVLRPKVDGA AHLHRLTADV PLDLFLLVSS
1801 AAGVLGTAGQ SNYAAANVFL DQLAHHRRAL GLPGVSVSFG AWAGEGLAAE HADLERMARL
1861 GHRALTPDQG RELVELSLRR GAPHLVAWSL DLPRLRETTA AGDDTAAALW RSLLPAPRTG
1921 QDGADGLADR LARLPEAERA ERVLALVREE ASRALGLRSA QSVRPDQPLR ELGMDSVTAV
1981 ELRNRIGTRI GAKLPATLLF DHPTPSRLAE YLLTTALATA GRPARRTAPG AQPARTATPA
2041 SDEPVAVVSM ACRLPGGVSD PEGLWHLVAQ GRDAVGPFPA GRWDVESLYD PDPEALGKSY
2101 AREGGFLDGI ESFDAGFFGI TPKEAAAMDP QQRLLLEMAW EALERAGTVP AELAGSTTGV
2161 YVGMFGSDYL AGSRLDQLDG YVGTGSALSV ASGRLSYALG LHGPALTVDT ACSSSLVATH
2221 LAAQALRSGE CDLALAGGVT LMVTPGTFVE FSRLRGLSPT GRCRSFSDDA DGAVWAEGAG
2281 MLVLKRLSDA RRDGDQVLAV LRGTAVNQDG RSQGLSAPNG PAQEQVIRRA LELSALGAAD
2341 IDYVEAHGTG TTLGDPIEAN ALSEVFGDSR PENRPLYLGS LKSNIGHAQA ASGVLGLIKV
2401 VQSLRHGTLP RTLHAGTPSQ HVDWDGSGLH LLQEAVDWPS SGERVRRAGV SAFGISGTNA
2461 HVIVEEAPPP AATEPNAEPM PGKRLFALSG RSEAGVRGQA ARLAQYLTED VALPDVAHTL
2521 ARHRSHFERR TAIVAADRDE LRAALDALAT GRTPLVPPRE EQTGKVAFVF AGHGGQWPGM
2581 GVELMAGSDA FREELARIDE AVRRHVGWSV LNVLRAPEEI APLDRTEFLQ PVLFAVNAAL
2641 AAAWRALGIT PDAVIGHSLG EIAAAYSAGA LTLDAAVTVV TRRAQAVVPL AGKGGMLSVE
2701 LPRAQVEELL APYAGRLFVA AVNSAHATAV SGDAEALAEV LHRLEERKIP ARRLSTPFAS
2761 HTPLMDPLRE ELLDRFADVR GARTPTPLYS TVLAEPVPGD RLDAAYWYAN LREPVRFADT
2821 VRRMLDDGYR YFVELSPHPS LGPSIEAVAA EAGIDAVGVG SLRRQQDGRD ILLRRLGELY
2881 AAGHTPDWPV LFPTGRRVDL PTYAFARERH WLAPAPASPA GGGGPLLGTH VEASDEPDRH
2941 LFQSDLDLRD SRFAYLTDHR VTGDVWLPGA AFLDMALEAA SALQDGGEVR LADVRFLRPL
3001 RLDEGRPVRL QLVLRPAEDG VRDFTIASAV TGERRTRWER HVSGRVTVTA GEPMADARLA
3061 VLREQCTEQV DLPGVYARLA ALGIDYGPAF RGLEEGRRTH SAALGRLAAH PAAGHLLHPA
3121 VLDAAFHTAA LPGDAPEGRA FVPAGFGRLR FTGLRTTPVW VTCELRSMAG DTATLDLRLW
3181 DENEQLVLEA EEFELAALSP LDGALFETRW QPRPPAQEPP ATGSWLILAD ETGVAVELAE
3241 RLGSSVPHVI VRRGEAFGVE GPGRYVLDPA DPQQLAHLLD EAFADGLPER VVQLSALDAP
3301 AIGEARTAEQ AARLCCLSTL HLVRTLADRP EGRAPRLFVV VRGSQAVGDS TQVTHPQQAL
3361 AWGFGLAVAQ EYPELATTLI DLPSTDGVDA LWEQLRHADD ERLVALRDTG RLVPRLARTR
3421 PDDGGHGELT PDGVYLITGG LGGLGRVVAE RLVRRGARRL ALLSRGRPGA DAAGWIKGLE
3481 ERGVTVHLAR ADVADRAGLT AALAALRRDA GPVAGVVHAA GVLDDATVAN LTDERVLRVL
3541 APKVLGTTLL TELIPEAGNL VLFASAAGLL GSAGQSPYSA ANAFLDAWAH HLSRTDRRAL
3601 SLDWGAWAGV GMVAESGTRA DETSRSGLVA FSPDEGGELF ERVLATSRRQ LAPIALDWEM
3661 LALDADAART RPLLGDLVTV PTGGADSDDL VKKVFAATTD HDRAVRLEAY VRARVGEVCG
3721 GAVDVSGTTV LKELGLDSLM LVRLRNAFAR ELGVELPAAA MFSASDIRGL VRALVAALPE
3781 RDTVTPEQPA DVTSEVLEVP ETELRPATRD VVRLLRSAQP GMPGAAHAVG LAVRLTTPTT
3841 RETLTGILTR LVARHAALRT AIVPGAEGGR QLRVDREPAN PVLRWTDVAA DVELDAGDRL
3901 RELLESPFDL TTAALWRFEL LDGGARGQIL VFGAHHAVSD LQSLLLVAGE IDAELSGTSL
3961 GDTVTNRDID LLIQAQRTEG TVPTGDGPGA AAAVEWREAF HGSGRLDLTL TRERPAARSY
4021 RAGSVTVAIP DGLMERVSAA ASGLAVTPAA FCLGTLTVLL AHRRERERFV LAVPVDTRIH
4081 ADAYDAVGFF GVPVPFPAEA GAGEPVEQVL RRTDGRLEKV LAKGAMFSDV LPTLAKQGLY
4141 RPNAPLVEVY FNYVRSSAGR LTNLEVLPAG TGWSDLDLMI TMTPDAGRIR LDHNLDILDA
4201 AATTDLGEEF LRLLARAVED PTAPVRTTAA SEAPAATEVL VASEVPPAAE ALAVSEAPAA
4261 TEVPPATEVP PAGEPAVVPP RPLAVAATFA LGNLPLMCEL ACNEGAGARD GGVTVAEAPY
4321 HHVLASLRDP SGVFADPATA VGVVLLRAAD LERFGPVDDA LLAELRTEYP AALRALSERT
4381 RKPLIVGFPP SARADDRLER WDSEVAAELA GLPGIAVLGP DDWTRHHAVG ERFDERTEKL
4441 AHLPFTPDFQ AAVALRLADV VRAVRRPAPK VIAVDGDETL WGGVAGEIGP EAVDLTGPRA
4501 LLARRLLQWR AAGALLALVS NNDEDTVRAV LDRPDSLLKA EHFSVLSAAW GPKSGRLAEA
4561 ARTLNLGTDS FLFLDDNPVE IAGVRSALPE VLSVTCPPTA ELDEFLGRLW PLVPAAATAE
4621 DGLRARFYEQ ERERDAVREH AGFEEFLAQL ELEVDIRALS AADVQRAEQL VRRTNQFTLR
4681 ARSADGGDLT RWRECGEVWT AAARDRFGDY GQIGLLAVRP GEGQLDVLAW MMSCRALGRG
4741 VEERLLRWLA DRAEELGCAK VRLTAERTPR NVPARRLVAA LGGGDQDDAY LETVVTPDQL
4801 RAFRSWQQQ
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