LOCUS       BAC68653.1              4881 aa    PRT              BCT 07-OCT-2016
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893 type I polyketide
            synthase AVES 4 protein.
ACCESSION   BA000030-950
PROTEIN_ID  BAC68653.1
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
            Contact:S Omura
            Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
            Kitasato, Sagamihara, Kanagawa 228-8555, Japan
            URL    :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete Genome Sequence and Comparative Analysis of the
            Industrial Microorganism Streptomyces avermitilis
  JOURNAL   Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: Deducing the ability of producing secondary
            metabolites
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE   4
  AUTHORS   Ikeda,H., Shin-ya,K. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and
            development of genome-minimized hosts for heterologous expression
            of biosynthetic gene clusters
  JOURNAL   J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT     This work was done in collaboration with Haruo Ikeda(*1),
            Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
            Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
            Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
            Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
            Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University
            *2 National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation
            *5 School of Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo
            *7 RIKEN, Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp
FEATURES             Qualifiers
     source          /db_xref="taxon:227882"
                     /mol_type="genomic DNA"
                     /note="This strain is also named as strain: ATCC 31267,
                     NCIMB 12804 or NRRL 8165."
                     /organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
                     /strain="MA-4680"
     protein         /gene="aveA4"
                     /locus_tag="SAVERM_943"
                     /old_locus_tag="SAV_943"
                     /transl_table=11
BEGIN
        1 MANEEKLRDY LKRVTADLLN VRRRLQQIES GEQEPIAIVG MACRFPGGVE SAEDFWELIA
       61 SGRDAVGEFP VDRGWDVEAF YDPEPGRAGS SYTRRGGFLE GAAEFDAGFF GISPREALAM
      121 DPQQRLMLEV SWEALERAGI DPATLRGSRT GVFAGLMSQD YATRLLSVPD DLAGYLGNGN
      181 AGSILSGRVA YTFGFEGPAV TVDTACSSSL VALHLACQSL RTGESSFALA GGVTVMSTPG
      241 MFVEFSRQRG LSPDGRCKAY ASAADGTGMS EGVGILLLER LSEAERRGHR VLAVVRGSAV
      301 NQDGASNGLT APNGPSQQRV IRQALACAGL SVADVDVVEG HGTGTTLGDP IEAQALLATY
      361 GQRAGDTPVW LGSVKSNIGH AQAAAGVAGV IKMVMALRAG VLPRTLHVDE PSSQVDWSSG
      421 SVRVLADEVE WPGVEGRLRR AGVSAFGVSG TNAHVILEEA SGGAGGGAGR LQELGPGVVS
      481 GSGVVPWVVS ARSELALRGQ ARRLRGVVAV GGGADGVGVS PAGVGRALVS ERSVFEHRAV
      541 VVAEDRDEFL HALDALAGGR PVPGVVEGRT TSGELAVLFA GQGTQRAGMG RELYEAYPVF
      601 AQAIDEICAE ADTARTDPGA PGLRDVLFAP QDSPEGRLIE DTGFAQPALF AFEVALFRLL
      661 ETWGLTPDYV LGHSVGELAA AHVAGMLCLA DAVALVVARG RLMQGLPSGG AMVAIEASED
      721 EILPLPDEYA SRVAHAAVNG PRSIVLSGDE DAVLDLAQQW AARGRRTRRL RTSHAFHSPH
      781 MDAMLGDFRR AAEQVTFSAP RIPVVSNVTG APLPAETMCT PDYWVEHARS TVRFADGISW
      841 LQEQGVTTCL EIGPDGTLSA LAQDSLSAPA RAIPALRPDQ PEARSVMTAL AELFVAGTAV
      901 EWAGVFEGTA REVGDGCGVE LPTYAFERER FWLDVEEGSA GGSGVSGMWG GPLWEAVECG
      961 DAGVVASLLG VDEGASLGAV VSALGEWGRV RHEREVVDGW RYREVWRPVS GGGVGGLSGA
     1021 WLVVSEGEAG PVDVVAEGLE RCGARVVRVE VEAGCVSREV LAGHLREAVD GEAVGGVVSL
     1081 VGWGSGVVQA GVASVGLVQA LGDVGVGARL WCVTGGAVSV GGRDAVWGPA SGVVWGLGRV
     1141 VGAEAPDRWG GLVDVPELVD ERVVDGLVGV LAGVGGGGES EFAVRSSGAF VRRLVRAPLE
     1201 EAVAEREWRP RGTVLVTGGT GELGAHVARW MARRGAEHLL LVSRRGESAQ GVEELRADLM
     1261 GLGARVSVVA CDAADREALA EVLRSAVPAE CPLGVVVHAA GVVDDGVLEG LSSERVTGVL
     1321 RAKALAAWNL HELTRGADLS GFVVFSSAAA TFGPAGQGSY AAANAYVEAI VRHRRGEGLP
     1381 GLAVAWGPWA GGGMAEGAVG QMRRRGLAAM TPETALVALG QALDHDETCV TVADIDWDRF
     1441 TANSLPGSRL SPLISDIPEA RLARETTGLD TATASPDSFS ARLKAMDTAE QERALLDLVR
     1501 TYAATVLGHS TPTAVRPERA FRDLGFVSVS AVELRNRLNA VTGLLLPTTL IFDYPTPSAL
     1561 AGYLKEQLEE GAGGQRDIAP PVPASRVDVD EPIAIVGMAC RFPGGVESAE DLWELVASGR
     1621 DAVGEFPVDR GWDVEAFYDP EPGRAGSSYT RRGGFLEGAA EFDAGFFGIS PREALAMDPQ
     1681 QRLMLEVSWE ALERAGIDPA TLRGSTTGVF AGMCSQDYAD LVRRATEDLE GYAMTGLSSS
     1741 VTSGRVAYTL GLEGPAVTVD TACSSSLVAL HLACQALRSG ECSLALAGGV TVMSTPGAFV
     1801 EFSRQRGLSP DGRCKAYGSG ADGVGWAEGV GVLLVERLSE AERRGHRVLA VVRGSAVNQD
     1861 GASNGLTAPN GPSQQRVIRQ ALACAGLSVA DVDVVEGHGT GTTLGDPIEA QALLATYGQG
     1921 RSGERPVWLG SVKSNIGHAQ AAAGVAGVIK MVMALRAGVL PRTLHVDEPS SQVDWSSGSV
     1981 RVLADEVEWP GVEGRLRRAG VSAFGVSGTN AHVILEEASG GADGGAGRLQ ELGPGVVSGS
     2041 GVVPWVVSAR SELALRGQAR RLRGVVAVGG GADGVGVSPA GVGRALVSER SVFEHRAVVV
     2101 AEDRDEFLHA LDALAEGAPT AGVVQGVAGP AADGKIAMLF GGQGTHWEGM AQELLGSSPV
     2161 FAQQMSDCAQ ALEPYLDWSL LDVLRGAPDA PPLQRVDVVQ PVLFAVMVSL AALWRSYGVH
     2221 PDAVAGHSQG EIAAAYVAGA LSLDDAARVT ALRSQALAAL AGQGAMASVG LPVEKLEPRL
     2281 ATWGDRLVIA AVNGARSAVV SGEPEAVDAL VEELSHEDVP ARRLMVDWAS HSPQVEAIQG
     2341 RLLELLAPIR ARTGDVPFYS TVTGERIDGT ELDADYWYRN LRQVVRFRDA TQALVRAGHT
     2401 VFIEACPHPA VAVGVQETLD EMGDLDSLVV GSLRRGEGGL RRFLMSVAEL FVGGVAVEWS
     2461 GVFGSVGRGV AGGCGVELPT YAFERERFWL DVEGAPRGSG VSGQWGGQLS EAVDTVRGGM
     2521 LRDCLAGLDP AAQAETVLDL VLTHAAAVLG HGTADAVVPE RAFRDLGFDS LTAVELRNRL
     2581 NTATGLRFPR TLVFDHPRPV ALAAHIHEQL SGGSPTTGTA LALALRAPAP RVDVDEPIAI
     2641 VGMACRFPGG VESAEDFWEL IASGRDAVGE FPVDRGWDVE AFYDPEPGRA GTSYTRCGGF
     2701 LQGAAEFDAG FFGISPREAL AMDPQQRLML EVSWEALERA GIDPATLHGS TTGVFAGVSQ
     2761 QDYAELLRRG TQDHEGYALT GVSNSVVSGR LSYTFGFEGP AVTVDTACSS SLVALHLACQ
     2821 ALRSGECSLA LAGGVTVMST PGAFVEFSRQ RGLSPDGRCK AYGSGADGVG WAEGVGVLLV
     2881 ERLSEAERRG HRVLAVVRGS AVNQDGASNG LTAPNGPSQQ RVIRQALACA GLSVADVDVV
     2941 EGHGTGTTLG DPIEAQALLA TYGQGRSGER PVWLGSVKSN IGHAQAAAGV AGVIKMVMAL
     3001 NHELLPTSLH IDEPSPHIDW SSGGVRLLTE PVPWQQNGRP RRAGVSAFGV SGTNAHVIIE
     3061 QAPVEAHVIS EPVPAEAHVI VEQAPVEAPH VVDATGPADL TEPQEEAAEP ECVADAVTEM
     3121 SAEPECVADA MSEMSAECVA EAVSDKSAEP ECVADAMSDK PALLPIPWLL SAKSERALRG
     3181 QARRLRQFAA RASDARPADV AHALAAQRSV FDHRAVVVAE DRDGFLQALD ALAEGRSADG
     3241 LIEGSVGPRG GHSGRRRGKT AMLFAGQGTQ RVGMGRQLYA AHPAYADALD QVLAELDGHL
     3301 DQPLRPLIHA SADLADVADA ADVLDRTRYA QPALFAVQVA LFRHLERLGV RADFVAGHSI
     3361 GELAAAHVAG VLPLAAACRL VAARGRLMEQ LAPGGAMVAV RASEAEARQA LDGREARVSV
     3421 AAVNGPASVV FSGAEDEVGN MADWFAERGR RVKRLRTGHA FHSPLMDPML EEFQQVAASL
     3481 TYSEPAIPMV STLTGDIVAA GELSDPEYWV RQVRRTVRFG DAISRLHTDG VRTFMELGPD
     3541 GTLSALAEEC LEATADSHPA DDDTGTPQEN LLIPLLRPDS PEPGTLLTGL ARLHTHGAAA
     3601 VNWPAALPER DRARHLDLPT YAFDHHRYWV DTSAGHPGDL SAAGLGTAGH PLLGSAVALA
     3661 ESQELLFTGR LSLRTHPWLA DHAIFGTVLL PGTAILELAV RAGDEVDCGT VEELTLRTPL
     3721 VLPEQGSVIL QLSVGAPQGP QTPEEPERRT FALYAREDDG LSSSSAAATG TEWTCHATGV
     3781 LTGTARPAEE HTQEPWPPAD AAPVDLDGWY EQLAGAGLGY GPVFQGLREV WRRGDEVFAV
     3841 VTLPESTEGQ AADAARYALH PALLDAALHP VVLRHEGDAA ADGHGWLPFS WTGVTVAASG
     3901 ASTLHVRLTV RTDEDAVGLL ATDASGRIVI SAGSLAFRPV SAEQLQAART GYHDHLFRIE
     3961 WRPLHLPTTP ARTADWALIG PGARRTAAVL ERNGASWQAY PDPAALAEAL AAGAPAPGMV
     4021 VISCEPDGAS APTDSALTDS ALTDSAPAGS APADSTALAD ATRQATTRVL ALLQEWVADE
     4081 RLAACRLALL THGSVTATPD EPVSDLAHAA VWGLVRSVQT ENPDRFLLAD TDDTDASRNA
     4141 LPLLAGEPQI ALRNGAVRIP RMTRVPVRQP QPSTTDADWD PEATVLITGG TGVLGRLVAR
     4201 HLATAHGVRH LLLATRRGTA ADGAADLVAE LAGLGAEATV AACDIGDRAA VAALLDQVPA
     4261 QHPLKAVIHT AGVVDDGILT SLTPERMEAV LHAKAFGAAH LHDLTRDAGL TTFTVFSSAA
     4321 ASFGSPGQGN YTAANAFLDA LMQHRHTQAL PGRSLAWGLW GEADGMTRNL AGTDFARMAR
     4381 GGLLPLSNAQ GLALLDTADR LGPFGDGLLL ATRLDAATLH AQATAGALPR ILHGLIRIPA
     4441 RRSADHGIAT DTPATLRERL AGLTIPAQRT GLLLELVRTH AAAVLGHPTS AVTAADGALP
     4501 DDLVPADTEF RDLGFDSLTA VELRNRINAV TGLRLPATLI FDQPSPAALA DHLATRLTAE
     4561 AGTPDEPAPA AAAAGAGSAG SAETGQQRST GSEKQQTRGG TSTETVESLF WIGHDTRRIE
     4621 ESMALLSAAS FFRPAFTDPS DIPEPTFVRL AQGEARAQGE ALARGETRPA LICLPTVAAV
     4681 SSVYQYSRFA AGLNGHRDVW YVPAPGFLEG EPLPSGIGAV TRMFADAIVR FTDGAPFALA
     4741 GHSAGGWFVY AVTSHLERLG VRPEAVVTMD AYLPDDGIAP VASALTSEIF DRVTQFVDVD
     4801 YTRLVAMGGY FRIFSGWSPP DITTPALFLR GRDGEQMPPP WGVPHTVLDI QGNHFTMLEQ
     4861 FADSTARHVD EWLTEIASVR R
//