LOCUS BAC68652.1 5532 aa PRT BCT 07-OCT-2016
DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 type I polyketide
synthase AVES 3 protein.
ACCESSION BA000030-949
PROTEIN_ID BAC68652.1
SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893
ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
Streptomycetaceae; Streptomyces.
REFERENCE 1 (bases 1 to 9025608)
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
Contact:S Omura
Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
Kitasato, Sagamihara, Kanagawa 228-8555, Japan
URL :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE 2
AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
TITLE Complete Genome Sequence and Comparative Analysis of the
Industrial Microorganism Streptomyces avermitilis
JOURNAL Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE 3
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Genome sequence of an industrial microorganism Streptomyces
avermitilis: Deducing the ability of producing secondary
metabolites
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE 4
AUTHORS Ikeda,H., Shin-ya,K. and Omura,S.
TITLE Genome mining of the Streptomyces avermitilis genome and
development of genome-minimized hosts for heterologous expression
of biosynthetic gene clusters
JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT This work was done in collaboration with Haruo Ikeda(*1),
Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
Hattori(*1,*7)
and Satoshi Omura(*1,*3).
Final finishing process and all annotation were done by H. Ikeda
and J. Ishikawa.
*1 Kitasato Institute for Life Sciences, Kitasato University
*2 National Institute of Infectious Diseases
*3 The Kitasato Institute
*4 National Institute of Technology and Evaluation
*5 School of Science, Kitasato University
*6 Institute of Medical Science, University of Tokyo
*7 RIKEN, Genomic Sciences Center
All the annotated genes identified are available from following
urls.
http://avermitilis.ls.kitasato-u.ac.jp
FEATURES Qualifiers
source /db_xref="taxon:227882"
/mol_type="genomic DNA"
/note="This strain is also named as strain: ATCC 31267,
NCIMB 12804 or NRRL 8165."
/organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
/strain="MA-4680"
protein /gene="aveA3"
/locus_tag="SAVERM_942"
/old_locus_tag="SAV_942"
/transl_table=11
BEGIN
1 MDTSSEKLVD ALRASLKANQ TLRARNEQLA AAMEASSEPI AIVGMACRFP GGVCSPEELW
61 ELVASGGDAI GEFPAGRGWD LEGLFDSDPD RSGTSYARYG GFLYEAGEFD ADFFGISPRE
121 ALAMDPQQRL LLETSWEAFE RAGIDPLSMR GSRTGVFAGV MYHDYGSRLG TIPEGFEGYI
181 GNGSGGAVAS GRVAYTLGLE GPAVSVDTAC SSSLVALHLA CQSLRSGECT LALAGGVTVM
241 STPHLFVEFS RQRGLSVDGR CKSFAGGADG TGMGEGVGML LVERLSDAVR LGHRVLAVLR
301 GSAVNQDGAS NGLTAPNGPA QERVIRQALA NAGLSVADVD VVEGHGTGTT LGDPIEAQAL
361 LATYGQRAGN RPLWLGSVKS NIGHAQAAAG VGGVIKMVMA LREGVLPRTL HVDEPSPQVD
421 WSAGAVRLLT EAVPWPGDAA GRLRRAGVSS FGVSGTNAHV ILEEAPAAGG CVAGGGVLEG
481 APGLAISVAE SVAAPVAVSA PVAESVPVPV PVPVPVPVSA RSEAGLRAQA EALRQYVAVR
541 PDVSLADVGA GLACGRAVLE HRAVVLAADR EELVQGLGAL AAGEPDRRVT TGHAPGGDRG
601 GVVFVFPGQG GQWAGMGVRL LASSPVFARR MQACEEALAP WVDWSVVDIL RRDAGDAVWE
661 RADVVQPVLF SVMVSLAALW RSYGIEPDAV LGHSQGEIAA AHVCGALSLK DAAKTVALRS
721 RALAAVRGRG GMASVPLPAQ EVEQLIGERW AGRLWVAAVN GPRSTAVSGD AEAVDEVLAY
781 CAGTGVRARR IPVDYASHCP HVQPLREELL ELLGDISPQP SGVPFFSTVE GTWLDTTTLD
841 AAYWYRNLHQ PVRFSDAVQA LADDGHRVFV EVSPHPTLVP AIEDTTEDTA EDVTAIGSLR
901 RGDNDTRRFL TALAHTHTTG IGTPTTWHHH YTHHHTHPHN HHLDLPTYPF QRQHYWLDAP
961 TGAGDVAAAG LEPAEHPLLA ATVQLADTDG CLLTGRLSLR SHPWLGDYEV GGAVLLSGSA
1021 FVELAVQVGE RVGCTRIEQL TVHAPLVVPV GGGVSVQVGV AAADGEGRRL VSVYARGGSA
1081 CGGGGASGGV WTCHASGVLV EAAAGGGVVV DGLAGVWPPR GAVAVDVDGV RDRLAGAGCV
1141 LGPVFSGLRA VWRDGGDLLA EVCLPEEAWG DAAGFGLHPA LLDGVVQPLS VLLPGGTGFG
1201 EGAGFGEGVR VPAVWGGVSL HRAGVTGVRV RVWAVGRGGG REAVSVVVGD EAGVPVASVD
1261 RLELRPVDMG QLRAVSVSAG RRGSLYAVQW AEVGPVPVCG QAWAWHEDVG ESGGGPVPGV
1321 VVLRCPDAGA GGGGGGGVGE VVGGVLGVVQ GWLGLERFAG SRLVVVTRGA VVAGQEDGPV
1381 DVVGAAVWGL VRSAQAEHPD RFVLLDLDTD TDTGTDLDTG AGAGAGAGWG VDGGHVAAVV
1441 ACGEPQLAVR GERVLAARLT RLESSVDVPA QRSGDVAGRE VLPWLSGGSV LVTGGTGVLG
1501 AAVARHLAGV CGVRDLLLVS RRGPDAPGAE GLRAELAALG AEVRIVACDV GERREVVRLL
1561 EGVPAGCPLT GVVHAAGVLD DATIASLTPE RLGTVFAAKV DAALLLDELT RGMELSAFVL
1621 FSSAAGILGS AGQGNYAAAN AALDALAYRR RAAGLPGVSL AWGLWEEASG MTGHLAGTDH
1681 RRIIRSGLHP MSTPDALALF DAALALDRPV LLPADLRPAP PLPPLLQDLL PATRRRTTRT
1741 TTTGGADNGA QLHARLAGQT HEQQHTTLLA LVRSHIATVL GHTTPDTIPP DRAFRDLGFD
1801 SLTAVELRNR LSRTTGLRLP TTLAFDHPNP TTLTHHLHTQ LLGSDSTASI PAPRAAAVPA
1861 DQDEPVAIIG MACRYPGGVT SAEELWELLA SGRDTVGEFP TDRGWDLEAL FDPEPGRPGT
1921 SYTRCGSFLY DAGEFDAGFF GISPREALAM DPQQRLLLEA SWEAMEQAGI DPTTVRGSQT
1981 GVFAGLIPQA YGPRLHENAA ADTEGYVLTG TSGSVASGRI SYTFGFEGPA VSVDTACSSS
2041 LVALHLACQA LRAGECSMAL AGGVTVMSSP GAFVEFSRQR GLAADGHCKA FSAAADGTGW
2101 GEGVGMLLVE RLSDARRNGH RVLAVVRGSA VNQDGASNGL TAPNGPSQQR VIRQALANAG
2161 LSAGDVDAVE AHGTGTTLGD PIEAQALLAT YGQDRAGEGP LWLGSVKSNV GHTQAAAGVA
2221 GVIKMVMALR NGLLPRTLHV DEPSPHVDWS AGAVQLLTET VPWPGGEGRL RRAGVSSFGV
2281 SGTNAHVILE EAPAHNIPSD TPADDVPGGP PAGEDAGSGE EAAAGSPGVW PWLVSAKSQP
2341 ALRAQAQALH AHLTDHPGLD LADVGYTLAH ARAVFDHRAT LIAADRDTFL QALQALAAGE
2401 PHPAVIHSSA PGGTGTGEAA GKTAFICSGQ GTQRPGMAHG LYHTHPVFAA ALNDICTHLD
2461 PHLDHPLLPL LTQDPNTQDT TTLEEAAALL QQTPYAQPAL FAFQVALHRL LTDGYHITPH
2521 YYAGHSLGEI TAAHLAGILT LTDATTLITQ RATLMQTMPP GTMTTLHTTP HHITHHITAH
2581 ENDLAIAAIN TPTSLVISGT PHTVQHITTL CQQQGIKTKT LPTNHAFHSP HTNPILNQLH
2641 QHTQTLTYHP PHTPLITANT PPDQLLTPHY WTQQARNTVD IATTTQTLHQ HGVTTYIELG
2701 PDNTLTTLTH HNLPNTPTTT LTLTHPHHHP QTHLLTNLAK TTTTWHPHHY THHHNQPHTH
2761 THLDLPTYPF QHHHYWLEST QPGAGNVSAA GLDPTEHPLL GATLELAEGD GCLLTGRLSL
2821 RTHPWLAGHA VGGVVLLPGT AFAELALHAG ESVGCDHVDE LTLHTPLVIP EVGDVTLQVA
2881 IAAPDESGRR MMTIHSRGEG GSGGADASAS AWTRHAAGVL SPAKDDDTAS YELLAGPWPP
2941 VGATPVDLNT AYDQMADAGF AYGLAFQGLR AAWRYGDDIL VEARLPEEVS GDAAAYGLHP
3001 ALLDAALQGT GLLSVAGPGT PVVPHVWNGL RFRTHGAVSV RACLSTLGAT GAAVCVRITD
3061 DTGVPVASVD RLELRPVDMG QLRAVSVSAG RRGSLYAVQW AEVGPVPVCG QAWAWHEDVG
3121 ESGGGPVPGV VVLRCPDAGA DGGGGGGVGE VVGGVLGVVQ GWLGLERFAG SRLVVVTRGA
3181 VVAGPEDGPV DVVGAAVWGL VRSAQAEHPD RFVLLDLDTD LDSGADADAG NEAGMGSGLD
3241 GGRVAAVVAC GEPQLAVRGE RVLAARLTRL ESPVDVSGRE VLPWLSGGSV LVTGGTGVLG
3301 AAVARHLAGV CGVRDLLLVS RRGPDAPGAE GLRAELAALG AEVRIVACDV GERREVVRLL
3361 EGVPAGCPLT GVVHAAGVLD DATIASLTPE RLGTVFAAKV DAALLLDELT RGMELSAFVL
3421 FSSAAGILGS AGQGNYAAAN AALDALAYRR RAAGLPGVSL AWGLWEEASG MTGHLAGTDH
3481 RRIIRSGLHP MSTPDALALF DAALALDRPV LLPADLRPAP PLPPLLQDLL PATRRRTTRT
3541 TTTGGADNGA QLHARLAGQT HEQQHTTLLA LVRSHIATVL GHNAPEMIPV DSAFRDLGFD
3601 SLTAVELRNR LGEATGLRLP TSLVFDQPNA ATLARHLRRE LMGDDAEGET PSQVALHQVA
3661 ADEPIAIVGM ACRFPGGVCS PEELWELVAS GGDAIGEFPA GRGWDLEGLF DSDPDRSGTS
3721 YARYGGFLYE AGEFDADFFG ISPREALAMD PQQRLLLETS WEAFERAGID PLSMRGSRTG
3781 VFAGVMYHDY AARLHHVPEG FEGLIANGSA GSVATGRVAY SFGLEGPAVT VDTACSSSLV
3841 ALHWAAQALR AGECSMALAG GVTVMSSPGT FVEFSRQRGL AADGRCKAYS AAADGTGWAE
3901 GVGMLLVERL SDARRNGHRV LAVVRGSAVN QDGASNGLTA PNGPSQQRVI RQALANAGLT
3961 PADVDAVEGH GTGTTLGDPI EAQALLAAYG QHRPHHRPLW LGSLKSNIGH AQAAAGVGGV
4021 IKMVMALRNG LLPQTLHVDE PTPQVDWSTG AVQLLTQPVP WPADPAGRPR HAGVSSFGVS
4081 GTNAHVILEE APAAAGGAAG GGVSVGAPNP ALPVAESEPV PVPVPVSARS EAGLRAQAQA
4141 LRQYVAARPD MSPADIGAGL ARGRAVLEHR AVILAADREE LAQALTALAA GEPHPHITTG
4201 HTRGSDRGGV VFVFPGQGGQ WAGMGLTLLT SSPVFAEHID ACEKALTPWV PWSLTDILHR
4261 DPDDPAWQQA DVVQPVLFSI MVSLAALWRS YGIEPDAVLG HSQGEIAAAH ICGALSLKDA
4321 AKTVALRSQA LAAVRGRGAM VSLPLPAQDV QQLISERWEG QLWVAALNGP HSTTVSGDTT
4381 AVEELLTHCA DTGLRAKRIP VDYASHCPHV QPLHDELLHL LGDITPQPST MPFFSTVVGH
4441 LVWYTTTLDA AYWYRNLHQP VRFSHAIQTL TDDGHRPFIE ISPHPTLVPA IEDTTENTTE
4501 NITATGSLRR GDNDTHRFLT ALAHTHTTGI RTPTTWHHHY TQTHPHPHNH HLDLPTYPFQ
4561 HQHYWLQPPT TTTDLTTTGL TPTHHPLLTA TLTLANNNTQ LLTGRLSLRT HPWLTDHTVV
4621 GTTLVPGTAL LELALQATTT DHLEELALHT PLVIPREGAV DVQVHINPPD DTDTRSLTIY
4681 SRSENAPAAA PWRHHATAVL GTKTSRIETG RSHDDLSMWP PAGAVRCADE ELAALYGDYE
4741 ANGFVYGPAF RGLTAAWRLG DEVFAEVRLP EQVHGEASAY NLHPALLDAA LHAAAFAPSG
4801 SLPQGSVPFS FTGVTLHAAN ASSLRVRLSP ADPNSGHAAV SVLVTDDTGT PVASVEALAV
4861 RPLAADELRA AERAVQRAEL FDMKWVEVPS DVLVSGGASV VVLDGADDLV GLAAEEDGVP
4921 GVVVLRCPDA GADGGGGGGG VGEVVGGVLG VVQGWLGLER FAGSRLVVVT RGAVVAGPED
4981 GPVDGPVDVV GAAVWGLVRS AQAEHPDRFV LLDLDTDLDS GADRDAGNEA GMGSGLDGGR
5041 VAAVVACGEP QLAVRGERVL AARLTRLESP VDVSGREVLP WLSGGSVLVT GGTGVLGAAV
5101 ARHLAGVCGV RDLLLVSRRG PDAPGAEGLR AELAALGAEV RIVACDVGER REVVRLLEGV
5161 PAGCPLTGVV HAAGVLDDAT IASLTPERLG TVFAAKVDAA LLLDELTRGM ELSAFVLFSS
5221 AAGILGSAGQ GNYAAANAAL DALAYRRRAA GLPGVSLAWG LWEEASGMTG HLAGTDHRRI
5281 IRSGLHPMST PDALALFDAA LALDRPVLLP ADLRPAPPLP PLLQDLLPAT RRRTTRTTTT
5341 GGADNGAQLH GRLAGQTHEQ QHTTLLALVR SHIATVLGHT TPDTIPPDRA FRDLGFDSLT
5401 AVELRNRLSH TTGLRLPTTL AFDHPNPTTL THHLHTQLVS KGLTAAAEPD AATTPPGLPS
5461 LLSELERLEA VVLSSTTSSA APLDDGARTR LASRLHSLAQ KLNGDDTAPD LAETSDEEMF
5521 ALIDREVGFE SQ
//