LOCUS BAC68649.1 6239 aa PRT BCT 07-OCT-2016
DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 type I polyketide
synthase AVES 2 protein.
ACCESSION BA000030-946
PROTEIN_ID BAC68649.1
SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893
ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
Streptomycetaceae; Streptomyces.
REFERENCE 1 (bases 1 to 9025608)
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
Contact:S Omura
Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
Kitasato, Sagamihara, Kanagawa 228-8555, Japan
URL :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE 2
AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
TITLE Complete Genome Sequence and Comparative Analysis of the
Industrial Microorganism Streptomyces avermitilis
JOURNAL Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE 3
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Genome sequence of an industrial microorganism Streptomyces
avermitilis: Deducing the ability of producing secondary
metabolites
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE 4
AUTHORS Ikeda,H., Shin-ya,K. and Omura,S.
TITLE Genome mining of the Streptomyces avermitilis genome and
development of genome-minimized hosts for heterologous expression
of biosynthetic gene clusters
JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT This work was done in collaboration with Haruo Ikeda(*1),
Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
Hattori(*1,*7)
and Satoshi Omura(*1,*3).
Final finishing process and all annotation were done by H. Ikeda
and J. Ishikawa.
*1 Kitasato Institute for Life Sciences, Kitasato University
*2 National Institute of Infectious Diseases
*3 The Kitasato Institute
*4 National Institute of Technology and Evaluation
*5 School of Science, Kitasato University
*6 Institute of Medical Science, University of Tokyo
*7 RIKEN, Genomic Sciences Center
All the annotated genes identified are available from following
urls.
http://avermitilis.ls.kitasato-u.ac.jp
FEATURES Qualifiers
source /db_xref="taxon:227882"
/mol_type="genomic DNA"
/note="This strain is also named as strain: ATCC 31267,
NCIMB 12804 or NRRL 8165."
/organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
/strain="MA-4680"
protein /gene="aveA2"
/locus_tag="SAVERM_939"
/old_locus_tag="SAV_939"
/transl_table=11
BEGIN
1 MQLANEAKLL EYLKRVTADL DRTRRRLYEV VEREQEPIAI VGMACRYPGG ATSPTRLWHL
61 VKSQTDAIGE FPTDRGWNLE QLYDPDPDRS GTSYTRSGGF LYDAGDFDAA FFELSPREAL
121 AMDPQQRLLL ETTWETFEQG GIDPRSMRGS RTGVFVGINP EDYTTGYTHQ PSNAVEGYLL
181 TGSAASIASG RISYNFGLEG PAITIDTACS SSLVALHLAC QALRSGECTM ALAGGASVMA
241 TPFVFTEFSR QRGLAADGRC KAFSAAADGT GWSEGVGMLL VERLSDARRN GHRVLAVVRG
301 SAVNQDGASN GLTAPNGRSQ VKVIRQALAN AHLSPADVDA VEAHGTGTTL GDPIEAQALV
361 EAYGQDRPNG RPLWLGTLKS NIGHSMAAAG VGGVIKMVMA LRNGLLPRTL HVDEPSPHVD
421 WSAGAVQLLT ETVPWPGGEG RLRRAGVSSF GVSGTNAHVI LEEAPAHNIP SDTPADDVPG
481 ESAADEDAGS GDEAAAGSPG VWPWLVSAKS QPALRAQAQA LHAHLTDHPG LDLADVGYTL
541 AHARAVFDHR ATLIAADRDT FLQALQALAA GEPHPAVIHS SAPGGTGTGE AAGKTAFICS
601 GQGTQRPGMA HGLYHTHPVF AAALNDICTH LDPHLDHPLL PLLTQDPNTQ DTTTLEEAAA
661 LLQQTRYAQP ALFAFQVALH RLLTDGYHIT PHYYAGHSLG EITAAHLAGI LTLTDATTLI
721 TQRATLMQTM PPGTMTTLHT TPHHITHHLT AHENDLAIAA INTPTSLVIS GTPHTVQHIT
781 TLCQQQGIKT KTLPTNHAFH SPHTNPILNQ LHQHTQTLTY HPPHTPLITA NTPPDQLLTP
841 HYWTQQARNT VDYATTTQTL HQHGVTTYIE LGPDNTLTTL THDNLPNTPT TTLTLTHPHH
901 HPQTHLLTNL AKTTTTWHPH HYTHHHNQPH THTHLDLPTY PFQHHHYWLQ PPGKPSDPSP
961 SEGREQATTP STPLRDVLVG KSPQERDEEL LRLVRTHAAA VLGHATPEVI VPNKAFKELG
1021 FDSLAAIQLR NRLLADVDLP LPATLIFDYP TPMALCQFLR AAIVGADTGT TTRLPLTAVP
1081 ADEPIAIVGM ACRYPGDVRT VDDLWQVVSG GHDAIGGFPT NRGWDLDTLY NPDPDHHGTS
1141 YTRSGGFLYD AGNFDPDFFG ISPREALAMD PQQRLLLETA WESIEHACIN PDSLRGTPTG
1201 VFAGLTYHDY AARFPTAPAG FEGYLGHGSA GSIASGRVAY ALGLEGPALT VDTACSSSLV
1261 ALHLACQALR SGECSMALAG GVTVMSTPAG FVEFSRQRGL AVDGRCKAFS AAADGTGWGE
1321 GVGMLLVERL SDARRLGHRI LAVVRGSAVN QDGASNGLTA PNGPSQERVI RLALANADLT
1381 PADVDAVEAH GTGTTLGDPI EAQALLATYG QDRPGNEPLW LGSMKSNIGH AQAAAGVGGV
1441 IKMVMALRNG LLPRTLHVDE PSPHVDWSAG AVQLLTETVP WPGGEGRLRR AGVSSFGVSG
1501 TNAHVILEEA PAHNIPSDTP ADDAPGEAAA DDVPGEAAGD DAGTGGEATG PAAGSPGVWP
1561 WLVSAKSQPA LRAQAQALHA HLTDHPGLDL ADVGYTLAHA RAVFDHRATL IAADRDTFLQ
1621 ALQALAAGEP HPAVIHSSAP GGTGTGEAAG KTAFICSGQG TQRPGMAHGL YHTHPVFAAA
1681 LNDICTHLDP HLDHPLLPLL TQDPNTQDTT TLEEAAALLQ QTPYAQPALF AFQVALHRLL
1741 TDGYHITPHY YAGHSLGEIT AAHLAGILTL TDATTLITQR ATLMQTMPPG TMTTLHTTPH
1801 HITHHLTAHE NDLAIAAINT PTSLVISGTP HTVQHITTLC QQQGIKTKTL PTKNAFHSPH
1861 TNPILNQLHQ HTQTLTYHPP HTPLITANTP PDQLLTPHYW TQQARNTVDY ATTTQTLHQH
1921 GVTTYIELGP DNTLTTLTHH NLPNTPTTTL TLTHPHHHPQ THLLTNLAKT TTTWHPHHYT
1981 HHHNQPHTHT HLDLPTYPFQ HQHYWLESTQ PGAGSGSGSG SGRAGTAGGT AEVESRFWDA
2041 VARQDLETVA TTLAVPPSAG LDTVVPALSA WHRHQHDQAR INTWTYQETW KPLTLPTTHQ
2101 PHQTWLIAIP ETQTHHPHIT NILTNLHHHG ITPIPLTLNH THTNPQHLHH TRQQAQNHTT
2161 GPITGLLSLL ALDETPHPHH PHTPTGTLLN LTLTQTHTQT HPPTPLWYAT TNATTTHPND
2221 PLTHPTQAQT WGLARTTLLE HPTHTAGIID LPTTPTPHTL HHLTQTLTQP HHQTQLAIRT
2281 TGTHTRRLTP TTLTPTHQPP TPTPHGTTLI TGGTGALATH LTHHLTTHQP TQHLLLTSRT
2341 GPHTPHAQHL TTQLQQKGIH LTITTCDTSN PDQLQQLLNT IPPQHPLTTV IHTAGILDDA
2401 TLTNLTPTQL NNVLRAKAHS AHLLHQLTQH TPLNAFVLYS SAAATFGAPG QANYAAANAY
2461 LDALAHHRHT HHLPATSIAW GTWQGNGLAT GQVSEHLRRR GMFAMPPELA VTAVDGAIAS
2521 GRPSLLVADI DWKKLGPVLS SKSSVLLEDL PQAQGTEEAR STVEQTESTN LRQLLMGRSR
2581 SEQEEELLSL VRIHSAAVLG RDDSEAIPPG RLFRDLGFDS LAAVELRNHL AAQTELALPT
2641 TLVFDYPSPT KLAQFLLSEI AEFQPDNSTP LPRPRAELDE PIAIVGMACR FPGGVTSADD
2701 FWDLISSEQD AIGGFPTDRG WDLDTLYDPD PDHPGTCYTR NGGFLYDAGH FDAEFFGISP
2761 REALAMDPQQ RLLLETAWET IEHAGINPHT LHGTPTGVFT GTNGQDHAAH IRQAPSGTEG
2821 FVLTGAATSI ASGRISYILG LEGPAVTLDT ACSSSLVALH LACQSLRSGE CTMALAGGAT
2881 VMTTPITFTE FARQRGLAPD GRCKAFSAAA DGTGWGEGVG MLLVERLSDA RRNGHRVLAV
2941 VRGSAVNQDG ASNGLTAPNG PSQQRVIRQA LANADLTPAD VDAVEAHGTG TTLGDPIEAQ
3001 AILATYGQDR PGNGPLWLGS VKSNVGHTQA AAGVAGVIKM VMALRHRTLP PTLHADEPSP
3061 HVDWSAGAVQ LLTETVPWPG GEGRPRRAGV SSFGVSGTNA HVILEEAPAD DVPGGPPADE
3121 DAGSGEEAAA GSPGVWPWLV SAKSQPALRA QAQALHAHLT DHPGLDLADV GYTLAHARAV
3181 FDHRATLIAA DRDTFLQALQ ALAAGEPHPA VIHSSAPGGT GTGEAAGKTA FICSGQGTQR
3241 PGMAHGLYHT HPVFAAALND ICTHLDPHLD HPLLPLLTQN DNDNDNEDAA ALLQQTPYAQ
3301 PALFAFQVAL HRLLTDGYHI TPHYYAGHSL GEITAAHLAG ILTLTDATTL ITQRATLMQT
3361 MPPGTMTTLH TTPHHITHHL TAHENDLAIA AINTPTSLVI SGTPHTVQHI TTLCQQQGIK
3421 TKTLPTNHAF HSPHTNPILN QLHQHTQTLT YHPPHTPLIT ANTPPDQLLT PHYWTQQARN
3481 TVDYATTTQT LHQHGVTTYI ELGPDNTLTT LTHHNLPNTP TTTLTLTHPH HHPQTHLLTN
3541 LAKTTTTWHP HHYTHHHNQP HTHTHLDLPT YPFQHHHYWL ELPSAQTSPG QRRSRRSAPD
3601 TAESEFWDAV NEEDLQSLAE TLDIDASALD TVVPALSAWH RHQHDQARIN TWTYQETWKP
3661 LTLPTTHQPH QTWLIAIPET QTHHPHITNI LTNLHHHGIT PIPLTVNHTH TNPQHLHHTL
3721 HHTRQQAQNH TTGPITGLLS LLALDETPHP HHPHTPTGTL LNLTLPQTHT QTHPPTPLWY
3781 ATTNATTTHP NDPLTHPTQA QTWGLARTTL LEHPTHTAGI IDLPTTPTPH TLHHLTQTLT
3841 QPHHQTQLAI RTTGTHTRRL TPTTLTPTHQ PPTPTPHGTT LITGGTGALA THLTHHLTTH
3901 QPTQHLLLTS RTGPHTPHAQ HLTTQLQQKG IHLTITTCDT SNPDQLQQLL NTIPPQHPLT
3961 TVIHTAGVNL FAPVSETDAE SFSSVTAAKA TGAAILHELL LDHETLEHFI LFSSGAGAWG
4021 SGNQCAYSAA NAYLDALATH RQTHGLPGAS IAWGPWAGKG MSAGDAAHGY LEKRGILPME
4081 PRMALAAFHR ARAQRPNSNL IIADIDWERF VPAFTARRHS PLIEDIPEVR QAAQELEAAA
4141 STAKTTTAQP IATSLRERLA RLTSSKQNQV LLGLIRTGIC TVLGLRNPEG IEDQRAFRDL
4201 GFDSLTSAQF SKELAKETGL PLPPSLVFDY PTPQECAAHL RTQLVDLDDE EDAALSNALP
4261 QVAHRRTVED EPIAIIGMAC RFPGGVRSAD DLWELLASGK DAIGVFPTDR GWDLDTLYDP
4321 DPDHPGTCYT RNGGFLYGAG HFDAEFFGIS PREALAMDPQ QRLLLETAWE TIEHAGINPH
4381 TLHGTPTGVF AGINAQDHAA HIRQSRDVET IEGYALTGSS GSVASGRVAY TLGLEGPAVS
4441 VDTACSSSLV ALHWAAQALR AGECSMALAG GVTVMSSPGT FVEFSRQRGL AADGRCKAYS
4501 AAADGTGWAE GVGMLLVERL SDARRNGHRV LAVVRGSAVN QDGASNGLTA PNGPSQQRVI
4561 RQALANAGLT PADVDAVEGH GTGTTLGDPI EAQALLAAYG QHRPHHRPLW LGSLKSNIGH
4621 AQAAAGVGGV IKMVMALRNG LLPQTLHVDE PTPQVDWSTG AVQLLTQPVP WPADPAGRPR
4681 HAGVSSFGVS GTNAHIILEE APTPQDSDTD DEPPANAPAL PHPLPLPVPV SARSEAGLRA
4741 QAQALRQYVA ARPDMSPADI GAGLARGRAV LEHRAVILAA DREELAQALT ALAAGEPHPH
4801 ITTGHTRGGD RGGVVFVFPG QGGQWAGMGL TLLTSSPVFA EHIDACEKAL TPWVPWSLTD
4861 ILHRDPDDPA WQQADVVQPV LFSIMVSLAA LWRSYGIEPD AVLGHSQGEI AAAHICGALS
4921 LKDAAKTVAL RSRALAAVRG RGAMASLPLP AQDVQQLISE RWEGQLWVAA LNGPHSTTVS
4981 GDTKAVDEVL AHCTDTGLRA KRIPVDYASH CPHVQPLHDE LLHLLGDITP QPSTVPFFST
5041 VEGTWLDTTT LDAAYWYRNL HQPVRFSHAI QTLTDDGHRA FIEISPHPTL VPAIEDTTEN
5101 TTENITATGS LRRGDNDTHR FLTALAHTHT TGIGTPTTWH HHYTQTHPHP NPHTHLDLPT
5161 YPFQHQHYWL QPPTTTTDLT TTGLTPTHHP LLTATLTLAD NNTQLLTGRL SLRTHPWLTD
5221 HTVAGMVLLP GTALLELALQ AGERVDCPRV EELTLHAPLV IPHTEDVTLQ VTVRAADESG
5281 HRALAIHSYS GTASSADREW TRHATGLLTH HADTDHRADT HTDACLGGSW PPPGAQPIEL
5341 GDVYGRMAAD SDIAYGPVFQ GLHAAWRFGD DVLAEVRLPE EALRDAPAAA FGVHPALLDA
5401 ALHATALTPQ NGDGSTENVA QESMPDRAAH QARLPFSWSG VSLHTAGSSV LRVRLSRSPQ
5461 HGNAVALTAA DEDGRPVVTI ESLALRPVST EELRAAADRT PEHESLFRLD WVSVPVPANA
5521 PSPTADRPWA VIGAGLPHLP GLTEHEHVTA YDEPADLLLA LDRGAPPPGV LVVGGVAHTE
5581 AREYSAEAPG ERGTEACEAR PDVVHVGVVH TAAVHAAAAQ MLARLQAWLG DERLADSRLL
5641 VLTCGAVARA SGDDATDLPG AAVWGLVRSA QSEHPDRITL LDFERGTEAE PGQLATALNC
5701 GERQLAVRPG GLFTPRLVRA PRVADAVPAV PAVAVPSAGH AAVPAAGPFL PGGTVLITGG
5761 TGVLGRLVAR HLVEAHGVRH LLLAGRRGPD AEGAPELRAE LGGLGATVEV VACDAADRQQ
5821 LADLLTRIPD DRPLTGVVHS AGILDDGVIT SLSPERLGAV LRAKADAALL LDELTRGAEL
5881 SAFVMFSSAS AVVGSPGQGN YAAANAVLDF LAHRRRAEGL PAVSLAWGLW EEGTGMTGHL
5941 DVDDHARISR AGMRPLPTAE ALALFDAALA DGEPFLMPAR LDLTAVRSGA ASAPVPPLLQ
6001 GLLQLPRSRS AAAAPGHGAP AADEAAAWRE RLARQSAGER RQALLRLVRS HVAAVLGHSG
6061 ADGIDASRAF RELGFDSLTA VELRNRLTAA TGLRLRATLA FDFPTPAALA EHLGERLLPD
6121 QEATGEQAGD QLSGGSEEDV RSLLTSIPIG RLRDAGLLGP LLTLADTGRG ASGAAAGPED
6181 APPSGQDTPA PVSIDEMDID DLMDLAHGHG TAPAREPADA EDSSSSRNRT HHTHEGETA
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