LOCUS BAC68648.1 3972 aa PRT BCT 07-OCT-2016
DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 type I polyketide
synthase AVES 1 protein.
ACCESSION BA000030-945
PROTEIN_ID BAC68648.1
SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893
ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
Streptomycetaceae; Streptomyces.
REFERENCE 1 (bases 1 to 9025608)
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
Contact:S Omura
Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
Kitasato, Sagamihara, Kanagawa 228-8555, Japan
URL :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE 2
AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
TITLE Complete Genome Sequence and Comparative Analysis of the
Industrial Microorganism Streptomyces avermitilis
JOURNAL Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE 3
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Genome sequence of an industrial microorganism Streptomyces
avermitilis: Deducing the ability of producing secondary
metabolites
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE 4
AUTHORS Ikeda,H., Shin-ya,K. and Omura,S.
TITLE Genome mining of the Streptomyces avermitilis genome and
development of genome-minimized hosts for heterologous expression
of biosynthetic gene clusters
JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT This work was done in collaboration with Haruo Ikeda(*1),
Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
Hattori(*1,*7)
and Satoshi Omura(*1,*3).
Final finishing process and all annotation were done by H. Ikeda
and J. Ishikawa.
*1 Kitasato Institute for Life Sciences, Kitasato University
*2 National Institute of Infectious Diseases
*3 The Kitasato Institute
*4 National Institute of Technology and Evaluation
*5 School of Science, Kitasato University
*6 Institute of Medical Science, University of Tokyo
*7 RIKEN, Genomic Sciences Center
All the annotated genes identified are available from following
urls.
http://avermitilis.ls.kitasato-u.ac.jp
FEATURES Qualifiers
source /db_xref="taxon:227882"
/mol_type="genomic DNA"
/note="This strain is also named as strain: ATCC 31267,
NCIMB 12804 or NRRL 8165."
/organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
/strain="MA-4680"
protein /gene="aveA1"
/locus_tag="SAVERM_938"
/old_locus_tag="SAV_938"
/transl_table=11
BEGIN
1 MQRMDGGEEP RPAAGEVLGV ADEADGGVVF VFPGQGPQWP GMGRELLDAS DVFRESVRAC
61 EAAFAPYVDW SVEQVLRDSP DAPGLDRVDV VQPTLFAVMI SLAALWRSQG VEPCAVLGHS
121 LGEIAAAHVS GGLSLADAAR VVTLWSQAQT TLAGTGALVS VAATPDELLP RIAPWTEDNP
181 ARLAVAAVNG PRSTVVSGAR EAVADLVADL TAAQVRTRMI PVDVPAHSPL MYAIEERVVS
241 GLLPITPRPS RIPFHSSVTG GRLDTRELDA AYWYRNMSST VRFEPAARLL LQQGPKTFVE
301 MSPHPVLTMG LQELAPDLGD TTGTADTVIM GTLRRGQGTL DHFLTSLAQL RGHGETSATT
361 VLSARLTALS PTQQQSLLLD LVRAHTMAVL NDDGNERTAS DAGPSASFAH LGFDSVMGVE
421 LRNRLSKATG LRLPVTLIFD HTTPAAVAAR LRTAALGHLD EDTAPVPDSP SGHGGTAAAD
481 DPIAIIGMAC RFPGGVRSPK DLWELAASGG DAIGPFPTDR GWPTEQRHAQ DPTQPGTFYP
541 QGGGFLHDAA HFDAGFFGIS PREALAMDPQ QRLLLETSWE AFERAGIDPL SVRGSRTGVF
601 AGALSFDYGP RMDTASSEGA ADVEGHILTG TTGSVLSGRI AYSFGLEGPA ITVDTGCSAS
661 LVTLHLACQS LRSGECTLAL AGGVSVMSTL GMFIEFSRQR GLSVDGRCKA YSAAADGTGW
721 GEGVGMLLVE RLSDAVRLGH RVLAVVRGSA VNQDGASNGL TAPNGPAQER VIRQALANAG
781 LSVADVDVVE GHGTGTTLGD PIEAQALLAT YGQRAGDRPL WLGSLKSNIG HTMAAAGVGG
841 VIKMVMALRE GVLPRTLHVD KPSPQVDWSA GAVRLLTEAV PWPGDAAGRL RRAGVSSFGI
901 GGTNAHVILE EAPAAGGCVA GGGVLEGAPG LAISVAESVA APVAVSAPVA ESVPVPVPVP
961 VPVPVSARSE AGLRAQAEAL RQYVAVRPDV SLADVGAGLA CGRAVLEHRA VVLAADREEL
1021 VQGLGALAAG EPDRRVTTGH APGGDRGGVV FVFPGQGGQW AGMGVRLLAS SPVFARRMQA
1081 CEEALAPWVD WSVVDILRRD AGDAVWERAD VVQPVLFSVM VSLAALWRSY GIEPDAVLGH
1141 SQGEIAAAHV CGALSLKDAA KTVALRSRAL AAVRGRGGMA SVPLPAQEVE QLIGERWAGR
1201 LWVAAVNGPR STAVSGDAEA VDEVLAYCAG TGVRARRIPV DYASHCPHVQ PLREELLELL
1261 GDISPQPSGV PFFSTVEGTW LDTTTLDAAY WYRNLHQPVR FSDAVQALAD DGHRVFVEVS
1321 PHPTLVPAIE DTTEDTAEDV TAIGSLRRGD NDTRRFLTAL AHTHTTGIGT PTTWHHHYTH
1381 HHTHPHPHTH LDLPTYPFQH QHYWLESSQP GAGSGSGAGA GSGAGSGRAG TAGGTAEVES
1441 RFWDAVARQD LETVATTLAV PPSAGLDTVV PALSAWHRHQ HDQARINTWT YQETWKPLTL
1501 PTTHQPHQTW LIAIPETQTH HPHITNILTN LHHHGITPIP LTLNHTHTNP QHLHHTLHHT
1561 RQQAQNHTTG AITGLLSLLA LDETPHPHHP HTPTGTLLNL TLTQTHTQTH PPTPLWYATT
1621 NATTTHPNDP LTHPTQAQTW GLARTTLLEH PTHTAGIIDL PTTPTPHTLQ HLTQTLTQPH
1681 HQTQLAIRTT GTHTRRLTPT TLTPTHQPPT PTPHGTTLIT GGTGALATHL THHLTTHQPT
1741 QHLLLTSRTG PHTPHAQHLT TQLQQKGIHL TITTCDTSNP DQLQQLLNTI PPQHPLTTVI
1801 HTAGILDDAT LTNLTPTQLN NVLRAKAHSA HLLHQLTQHT PLTAFVLYSS AAATFGAPGQ
1861 ANYAAANAYL DALAHHRHTH HLPATSIAWG TWQGNGLADS DKARAYLDRR GFRPMSPELA
1921 TAAVTQAIAD TERPYVVIAD IDWSKIEHTS QTSDLVSAAR EREPAVQRPT PPAELHKTLA
1981 HQTSADQRAA LLELVRDHVA AVLRHADPKA IAPDQSFRAL GFDSLTAVEF RNLLIKATGL
2041 RLPVSLVFDH PTPAKLAVHL QNQLRGTAAE SAPSAAAVTA EASVTEPIAI VGMACRFPGG
2101 VTSADDFWDL ISSEQDAIGG FPTDRGWDLD TLYDPDPDHP GTCYTRNGGF LYDAGHFDAE
2161 FFGISPREAL AMDPQQRLLL ETAWETIEHA GINPHTLHGT PTGVFTGTNG QDYALRVHNA
2221 GQSTDGFALT GTAGSVISGR ISYTFGFEGP AVSVDTACSS SLVALHLACQ ALRAGECSMA
2281 LAGGVTVMSS PGAFVEFSRQ RGLAADGHCK AFSAAADGTG WGEGVGMLLV ERLSDAHRNG
2341 HRVLAVVRGS AVNQDGASNG LTAPNGPSQQ RVIRQALANA GLSAGDVDAV EAHGTGTTLG
2401 DPIEAQALLA TYGQDRAGEG PLWLGSVKSN VGHTQAAAGV AGVIKMVMAL RHGLLPRTLH
2461 VDEPSPHVDW SAGAVQLLTE TVPWPGGEGR LRRAGVSSFG VSGTNAHVIL EEAPADDVPG
2521 GPPAGEGDAG SDDEAAAGSP GVWPWLVSAK SQPALRAQAQ ALHAHLTDHP GLDLADVGYT
2581 LAHARAVFDH RATLIAADRD TFLQALQALA AGEPHPAVIH SSAPGGTGTG EAAGKTAFIC
2641 SGQGTQRPGM AHGLYHTHPV FAAALNDICT HLDPHLDHPL LPLLTQNDND NEDAAALLQQ
2701 TRYAQPALFA FQVALHRLLT DGYHITPHYY AGHSLGEITA AHLAGILTLT DATTLITQRA
2761 TLMQTMPPGT MTTLHTTPHH ITHHLTAHEN DLAIAAINTP TSLVISGTPH TVQHITTLCQ
2821 QQGIKTKTLP TNHAFHSPHT NPILNQLHQH TQTLTYHPPH TPLITANTPP DQLLTPHYWT
2881 QQARNTVDYA TTTQTLHQHG VTTYIELGPD NTLTTLTHHN LPNPPTTTLT LTHPHHHPQT
2941 HLLTNLAKTT TTWHPHHYTH HDNQPHTHTH LDLPTYPFQH HHYWLESTQP GAGNVSAAGL
3001 DPTEHPLLGA TLELATDGGA LLAGRLSLRS HPWLADHAVG GTVLLSGATF LELALHAGTY
3061 VGCDRVDELT LHAPLVVPVD GGVSVQVGVA AADGEGRRLV SVYARGGSAC GGGGASGGVW
3121 TCHASGVLVE AAAGGVVVDG LAGVWPPRGA VAVDVDGVRD RLAGAGCVLG PVFSGLRAVW
3181 RDGGDLLAEV CLPEEAWGDA AGFGLHPALL DGVVQPLSVL LPGGTGFGEG AGFGEGVRVP
3241 AVWGGVSLHR AGVTGVRVRV SAVGRGGGRE AVSVVVGDEA GVPVASVDRL ELRPVDMGQL
3301 RAVSVSAGRR GSLYAVQWAE VGPVPVCGQA WAWHEDVGES GGGPVPGVVV LRCPDAGAGG
3361 GGGGGGGGGV GEVVGGVLGV VQGWLGLERF AGSRLVVVTR GAVVAGPEDG PVDVVGASVW
3421 GLVRSAQAEH PDRFVLLDLD TDTGTDLDTG AGAGWGVDGG RVAAVVACGE PQLAVRGERL
3481 LAARLKRLES SGDVPAQRSG DTRARRSDVP AQRSGGVPAR RSVDVSGREV LPWLSGGSVL
3541 VTGGTGVLGA AVARHLAGVC GVRDLLLVSR RGPDAPGAEG LRAELAALGA EVRIVACDVG
3601 ERREVVRLLE GVPAGCPLTG VVHAAGVLDD ATIASLTPER LGTVFAAKVD AALLLDELTR
3661 GMELSAFVLF SSAAGILGSA GQGNYAAANA ALDALAYRRR AAGLPGVSLA WGLWEEASGM
3721 TGHLAGTDHR RIIRSGLHPM STPDALALFD AALALDRPVL LPADLRPAPP LPPLLQDLLP
3781 ATRRRTTRTT TTGGADNGAQ LHARLAGQTH EQQHTTLLAL VRSHIATVLG HTTPDTIPPD
3841 RAFRDLGFDS LTAVELRNRL SRTTGLRLPT TLAFDHPNPT TLTHHLHTQL QPQPDNAVAP
3901 VLAELDKLES ALSALDKTDS ASERVTLRLK SLMLRWNAPQ HPTAESADDD EKFTSATEAE
3961 IFKFIDNDLG LS
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