LOCUS BAC68129.1 7746 aa PRT BCT 07-OCT-2016 DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 modular polyketide synthase protein. ACCESSION BA000030-423 PROTEIN_ID BAC68129.1 SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893 ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 9025608) AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C., Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T., Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M. TITLE Direct Submission JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases. Contact:S Omura Kitasato University, Kitasato Institute for Life Sciences; 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan URL :http://avermitilis.ls.kitasato-u.ac.jp/ REFERENCE 2 AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H., Shiba,T., Sakaki,Y., Hattori,M. and Omura,S. TITLE Complete Genome Sequence and Comparative Analysis of the Industrial Microorganism Streptomyces avermitilis JOURNAL Nat. Biotechnol. 21, 526-531 (2003) REFERENCE 3 AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C., Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T., Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M. TITLE Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001) REFERENCE 4 AUTHORS Ikeda,H., Shin-ya,K. and Omura,S. TITLE Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014) COMMENT This work was done in collaboration with Haruo Ikeda(*1), Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7) and Satoshi Omura(*1,*3). Final finishing process and all annotation were done by H. Ikeda and J. Ishikawa. *1 Kitasato Institute for Life Sciences, Kitasato University *2 National Institute of Infectious Diseases *3 The Kitasato Institute *4 National Institute of Technology and Evaluation *5 School of Science, Kitasato University *6 Institute of Medical Science, University of Tokyo *7 RIKEN, Genomic Sciences Center All the annotated genes identified are available from following urls. http://avermitilis.ls.kitasato-u.ac.jp FEATURES Qualifiers source /db_xref="taxon:227882" /mol_type="genomic DNA" /note="This strain is also named as strain: ATCC 31267, NCIMB 12804 or NRRL 8165." /organism="Streptomyces avermitilis MA-4680 = NBRC 14893" /strain="MA-4680" protein /gene="pteA1" /locus_tag="SAVERM_419" /old_locus_tag="SAV_419" /transl_table=11 BEGIN 1 MVESELNATG NRDCSASADS ADGIAVIGLA CRLPGAADPA AFWRLLSEGA DAITDVPPDR 61 WDGAVVADAS APDRTGIRRG GFLDSIGDFD AGFFGLSPKE AAAMDPQQRL VLELAWEALE 121 DAHVRAATLR STRTGVFVGA MWDDYATLHH RSGLTAISPH TVTGLHRSII ANRVSYFLGL 181 NGPSLTVDSG QSSSLVSVHL ACESLRKGES TIALAGGVNL NIVPESALGA AKFGGLSPDG 241 RCFTFDARAN GYVRGEGGGI VVLKPLARAV ADGDPVYCVI RGSAVNNDGG GDGLTVPLQS 301 GQEQVLRLAY ERAGVNPADV GYVELHGTGT KVGDPIEAAA LGAVLGTGRE PGRPLRVGSA 361 KTNVGHLEGA AGITGLLKAV LSLNHRELPA SLNFGTPNPA IPLDRLNLRV QTEHSEWAAE 421 DGRPLLAGVS SFGMGGTNCH IVLASGAAVE AGEGATAGGG AAPTFWPLSA KTASGLRAQA 481 AALLAHTEAP LGLALPDVGW SLATGRTAFE HRAVVVGEVR DDFLRALREL STGGIDAALT 541 TGRAGPRGEL AFLFSGQGSQ RAGMGRELAE SVPAFASALD EVCAHLDPLL PRPLREVMFA 601 PVGTGEAAEL DQTLYTQTSL FAVEVALFRL LESWDITPDV LMGHSIGELA AAHVAGVLSL 661 ADACALVAAR GRLMQALPAG GAMIAVQAAE DEVRARIGER TDRVSIAALN GPDSVVVSGD 721 EDLATEIADA FAALGRKTSR LRVSHAFHSP HMEPMLAEFR NVAEGLTFHA PRIPIVSNVT 781 GRLSEEPSGY EGCTAAYWVR HVREAVRFAD GVARLDEQGV RTYLELGPGG VLASMARAGA 841 DSESLFVPAL RTRRPEAQAL LAAVASLHVH GVEPDWDALF GGGRGARRKV ALPTYAFERQ 901 RYWLDGDTTS PVATTGWAPV APQPDAIAET DSAPVGALGR RLAGLAESER DEAVLDMVRA 961 HIAAVLGHAE ARQVETEWTF KDLGFDSLSS VELRNQLSEA TGLRLPSGLL FDHPTPAALA 1021 RHLAAQSLGG GDAAAAAPAT VADPHEPIAI VAMSCRLPGG VSSPEDLWRL LASGGDGISG 1081 FPTDRGWDVE TLYDPEPGTP GKSSTRHGGF LHEAAEFDAG FFGISPREAA AIDPQQRLVL 1141 ETAWEAFERA GIDPATLRGS RAGVFIGATA QDYGPRLHEP ADGVEGYLLT GTTTSVASGR 1201 VAYSFGLEGP AVTVDTACSS SLVALHLAVQ SLRSGECTMA LAGGVTVMST PGMFVEFSRQ 1261 RGLSADGRCK AFAAGADGTG WAEGVGMLLV ERLSDARRNG HQVLAVVRGS AVNQDGASNG 1321 LTAPNGPSQQ RVVRQALAAA GLAPADVDAV EAHGTGTLLG DPIEAEALIA AYGQGRDGDR 1381 PLWLGSLKSN IGHTQAAAGV AGVIKMVMAM RHGVLPRTLH VDEPTPHVDW SASGVRLLTE 1441 AVEWPARDLP RRAAVSSFGI SGTNAHVIVE QAATSEEPAR GTAVAGPVPW VVSAKSDVAL 1501 REQAGRLLSF LDAEGVGGAG VRPEDVALSL ATSRAVLERR AAVVGGDLAE LRQGLEALAS 1561 GASGAAPVGG AVGGRVGFLF SGQGSQRIGM GRELYAAYPV FAAAYDEVCA FLDAPVDVDS 1621 EELNQTGTTQ PALFAVEVAL FRLLESWGIR PDYVAGHSVG EIAAAHVAGV LSLEDAAKLV 1681 SARAALMQAL PDGGAMVAVQ ATEDEVLRHL TDGVGIAAVN GPRSVVVSGA EDAVTAVGEI 1741 FAGRGRKTSR LKVSHAFHSP LMDPMLEEFA AVVRGLTFSE SRIPVVSNLT GRLAEVYTPE 1801 YWVRHVREAV RFADGIETLG ELGVTTFVEV GPGGVLSALA QGCFDDGTDI VTVPVLRADR 1861 PEPYALVTAI GRLHTHGISP DWQVLFPGAR RVDLPTYAFQ RERYWLDAPR AATAGAPDAM 1921 DAEFWDSVES EDRASLGALL GLEPTELDVV ASKLSAWRRK RREQSTTDGW RYRITWQPLD 1981 DMVRAAPSGT WLYVVSEETA WTEAIRAGLT ELGVALVPFA VGEDTDRDAL ARAFADAGQE 2041 QADGILFAAA QGEAGANALQ RLVLLVQALG DAGIEAPLWC LTSGAVSTGT ADLLTDPVSA 2101 QLWGLGRIVA LEQPQRWGGL VDLPAELDSR ALERLAGLLA QADEDQLAVR ASGVYGRRLV 2161 RAPLSAAPAD APWSPRGTVL VTGGTGALGG QVARWLAGAG AEHLVLTSRR GPDAPGAAEL 2221 KAELEELGAQ VTVVACDAAD RDALAELFGR YIVNAVVHTA GVLDDGLVES LTPERLNHVL 2281 RPKVDAALHL HELTRDRQDL DAFVLFSSMT GVWGNGGQGA YGAANAFLDA LAEHRRAQGV 2341 PALAVAWGSW ADGGMADGAA GDHLRRRGVR AIAALPAISV LHGALTHGET SMTVADVDWE 2401 RFVPAFVGTR PCPLLLGVPE AREALEARAR AAQSPEVPVS ALVQRLLGAT PGEQGRILLD 2461 LVREQAATVL GHTGKGAFEA DRTFRETGFD SLTAVELRHR LNTATGLRLP TTLVFDHPTP 2521 TALARHLGEE LLGRHGLETA AAQATAAAAA DEPLAIVGMS CRLPGGVQSP EDLWELLSSG 2581 RDAMSGFPTD RGWDIDALYD PDPDRPGKTY SREGGFIQGA DRFDAGLFGI SPREALAMDP 2641 QQRLLLETAW EAFERAGIAL ASVRASRTGV FIGTNGQDYA NGLRNAPEEI EGYALTGKAA 2701 SVVSGRISYT FGLEGPAVTV DTACSSSLVA LHLAAQALRS GECSMALVGG VTVMTTPDLF 2761 VEFSRQRGLS PDGRCKAFAA GADGTGWGEG VGLLLVERLS DARRNGHQVL ALVRGSAVNQ 2821 DGASNGLTAP NGPSQQRVIR QALASAGLTP ADVDAVEAHG TGTRLGDPIE AQALLATYGQ 2881 EHSDDRPVWL GSVKSNIGHT QAAAGVAGVI KMVLAMRHGV LPQTLHVDEP TAHVDWSAGA 2941 VRLLTEPVQW PGTTGPRRAA VSSFGIGGTN AHTIIEEAPA AAAAEPAREH RPVPVPWVLS 3001 AKSEVALRAQ AERLLAFATD DVSPVDAGFS SATTRSALEH RAAVIGSDPA ELRAGLEALA 3061 AGEPAANVVA GRAHSADKVG FLFSGQGSQR LGMGRELYAA YPVFAAAYDE VCALLDATVD 3121 VDAETLHQTG STQPALFAVE VALFRLLESW GIRPDYVAGH SVGEIAAAHV AGVLSLEDAA 3181 KLVSARAALM KALPAGGVMV AVQAAEDEML PHLIDRAGIA AINGPRSVVI SGAEDAVTAI 3241 AEVFAAQGRK TSRLKVSHAF HSPLMDPMLE EFAEVVRGLT FSEPWIPVVS NLTGRLTESY 3301 TPEYWVRHVR EAVRFADGVL TLHELGVTTF VEIGPGGVLS ALVQGCLDDG TDIVTIPALR 3361 ADRPEPQALT TAYAQLHVSG AEVDWHAFFP GARRVELPTY AFQRERYWLD APASAGDMRA 3421 VGQGEAGHPL LGAAVPLADS VGHLLTGRLS KHTHPWLVDH AVSGVALLPG TAFVELAITA 3481 ADAVGCDLLE ELTLETPLLV PERGGVALQV HVGADDGSGR RPLTVHSQID DGDAYAHEDD 3541 SERAWVRHAS GVLTVATGGP VDGSLTAWPP VGAEPVDVDG FYDRLAGMAL DYGPVFQGLR 3601 AAWRSGDDFF AEVELPGAER TDAGAYGLHP ALFDAALHTV WLGAVEPEAG TGNGLLPFAW 3661 SGVRLAAAGA SDLRVKVSRA GTGTSTVSLV LADGTGGPVA EVDSLTLRPV PADQLRAGSG 3721 SDDAVFGLKW TPVSLPSAPD GMRIETYEDL AALRATDPPA DTEADAAAAA DAVVVPCPTG 3781 TGADLATRVR EVTHAVLELV QWWLAEERPG RLVLVTRGGD LAQSAVCGLV RSAQTENPDR 3841 IVLVETSSDA HAGAGSGVDD ADLARVLPGL IASGEPQAAV HADDEVRVPR LVRVAVPDAE 3901 PELPGLGSGT VLLTGASGGL GGLFARHLVA EHGVRSLLLV SRRGGDAPGA AELTADLTAQ 3961 GADVTWAACD VADRAAVRAL LAGPGQSLSA IIHTAGVLDD GIIGSLTPER LDAVFRPKVD 4021 AALNLHDLAG ELSGDLSAFV LFSSVAGTLG TPGQANYAAA NTFLDALAEH RRAAGQRATS 4081 LAWGLWAQDS ESAMTGSLDH TDLTRIQRMG LAAIPSSDGL RLFDAALALD RAVVAPLRLD 4141 LGGLQGTVPP VLRGLRGTVR GTARRTAQTA PKGSLGQRLA GLAEAEREQV VLDLVRTEVA 4201 AVLGHAGAQS VGADDSFKDI GFDSLTAVEL RNRLNSAVGM RLPATLIFDY PNPLTLAHFL 4261 TGEAAGGEAA TAVPTTLSTA TGTADEPIAI VGMACRYPGG VQSPEDLWQL VFSGRDAVSG 4321 FPEGRGWDVE QLYDPNPDQW GTSYTREGGF LHDAADFDAE FFGISPREAL AMDPQQRLLL 4381 ETSWEAFERA GIDPATVRGS RTGVFAGVMY HDYGGRVHTS PPGLEGYLVN GSAGSIASGR 4441 VSYTFGLEGP AVTVDTACSS SLVALHLAAQ ALRSGECSMA LVGGVTVMAG PSVFVEFSRQ 4501 RGLSADGRCK AFGAGADGTG WAEGVGMLLV ERLSDARRNG HKVLAVVRGT AVNQDGASNG 4561 LTAPNGPSQQ RVIRQALANA GLSSDEVDAV EAHGTGTRLG DPIEAQALIA TYGQERSEDR 4621 PLWLGSLKSN IGHSQAAAGV GGVIKMVMAM QHGVLPQTLH VDEPTPHVDW SAGAVQLLTE 4681 AVEWPASDGP RRAAVSSFGV SGTNAHVIVE QAATSEVTAR GTAVAGPVPW VLSAKSDAAL 4741 REQAGRLLSF LDAEGVGGAG VRPEDVAYSL ATSRAVLECR AAVVGEELGE FRQGLEGIVS 4801 GAAPVGGAVG GRVGFLFSGQ GSQRIGMGRE LYAAYPVFAA AYDEVCALLD ATVDVDAETL 4861 HQTGSTQPAL FAVEVALFRL LESWGIRPDY VAGHSVGEIA AAHVAGVLSL EDAAKLVSAR 4921 AALMQALPAG GAMVAIQATE AEVLPHLTHG VGLAAINGPR SVVLSGSEDA VLDIAEVFAQ 4981 QGRKTSRLKV SHAFHSPLMD PMLEEFAEVV RGLTFSEPRI PVVSNLTGRL AEVYIPEYWV 5041 RHVREAVRFA DGLHTLHELG VTMFVEIGPG GVLSALVQGC LDDGTHIVTV PALRADRPEP 5101 YALVTAVGQL HTHGISPEWQ ALFPGARRVD LPTYAFQRER YWLDAPQASG DVRAAGLGAA 5161 DHPLLGAAIA TADSDGAVLT GLLSLGTHPW LADHAVNGIV LLPGTAFVEL AIRAGDETGC 5221 GWIEDLTLEL PLVVPERGGV TLQVAVGPED ESGRRQLSVH SRVDDRSWLR HATGVLSSAE 5281 APSAAKLGAW PPAGAEAVDL TAFYEGMAAA GLDYGPVFQG LRSVWRDGDD VFAEVELPDE 5341 SAAEAAAFAL HPALLDAALH ALAAGGLVSL DDSPALPFAW SGVVVQAAGA AMVRVKLSRT 5401 ATGSVTLAVA DGAGDPVASV ESLSLRAASA EQLPGAVGGD QLFGLEWTRF TLPSATDALM 5461 IETVADFDAL RESEGTPDVV VVPCPAGSGR ETADRVHSTT SEVLALVQWW LAEERAGRLA 5521 LVTRPGDLAH AAVWGLVRSA QSENPDRIVL VEAEETDEAV RVLPAALASG EPQFAVRDGE 5581 VFVPRLVKAT RSATGTATGT PDFGVGPVLL TGASGALGGL VARHLVAEHG VRSLLLLSRR 5641 GAEAPGAVEL EAELAAWGAE VRWAACDAAD RDALAEVLAG TPVTAVVHAA GVLDDGVIAA 5701 LTPERMEKVL RPKTDAVLNL HELTSDLSAF VVFSSVSGIL GSAGQGNYAA ANAFLDAFAE 5761 ARRARGLPAT SLAWGLWEQG SGMADRLDQA DLARLKRVGL APIAVDEGLR LFDAALALDR 5821 AVVAPLRLDL GGLQGTVPPV LRGLRGTVRG TARRMAQTAP KGSLGQRLAG LPQAEREQVV 5881 LDLVRAEVAA VLGHASAQAV QPEHAFQDAG FDSLTSVELR NRLNAATGLR LPVTMVFDHP 5941 TPVALSRFLL AETLGVQEQA EAAIAAVTGT DEAIAIVGMA CRFPGDVRSP EDLWRLVASG 6001 GDAISGFPED RGWDVENLYD PDPDRSGKSY VRHGGFLHEA AEFDPAFFGI SPREALAMDP 6061 QQRLLLETSW EAFERAGIDP ATVRGSRTGV FAGVMYHDYG GRVKTAPEGM DAYLGSGSAG 6121 SIASGRVSYT FGLEGPAVTV DTACSSSLVA LHLATQALRS GECSMALVGG VTVMATPSTF 6181 VEFSRQRGLS ADGRCKAFAA GADGTGWAEG AGMLLVERLS DARRNGHTVL AVVRGTAVNQ 6241 DGASNGLTAP NGPSQQRVIR QALANAGVSS EQVDAVEAHG TGTKLGDPIE AQALIATYGQ 6301 ERPGDRPLWL GSLKSNIGHA QAAAGVGGVI KMVMAMRHGA LPRTLHVDEP TPHVDWSAGD 6361 VRLLTEAMEW PETDHPRRAA VSSFGISGTN AHVIVEQAPD TAELPPVPDS GKAVPWVLSG 6421 RTEAALRAQA ERLLSLVPEM DLPPADIGFS LATTRSAMEH RAAVVGESRD ELLEGLRALA 6481 AGSPSTRVVL GEPGAGGKSG FLFSGQGSQR IGMGRELYDA FPVFAAAYDE VCALVDAPVD 6541 VDSEELNQTG TTQPALFAVE VALFRLLESW GIRPDYVAGH SVGEIAAAHV AGVLSLEDAA 6601 KLVSARAALM QALPADGAMV AVQATEDEVL PHLTDGVGIA AVNGPQSVVV SGAEDVVVAI 6661 GEAFRERGRK TSRLKVSHAF HSPLMDPMLE EFAEAVSGLS FNEPRLPVVS NLTGRLAEPY 6721 TPEYWVRHVR EAVRFADGLH TLHELGVTTF VEIGPGGVLS ALAQGCLDGD IVTVPAVRTD 6781 RPEPQAVVTA LAELHAHGVS PDWRALFPGA RRVDLPTYPF QYERLWLEAP EEYTGTAAAT 6841 GLGLGAAEHP LAGAAVALPG AGGFLVTGRL SLRTHPWLAD HTVMDSVLLP GTALVELAVR 6901 AGEEAGCAQV EDLTLEAPLI VPERGGVAVQ VWVEAEEEPG RCALSVHSRR EDAPDDAPWV 6961 RHAVGRLTDA LPEPPHGADL GAWPPAGAEA VDLTGFYEGL DGLGLGYGPV FRGLRSVWRS 7021 GDDVLAEVAL PEGTEAGAFA VHPALLDAAL HAVGAGGLVP VLDGPLLPFA WSEVGVRAAG 7081 ATALRVKLSR TGTDAVSLTV ADASGGLVAT VGSLSLRPVS REQLLAAGGS GRRADDSLFG 7141 LAWQPAVLTE TDAAAGLDVR SYADLAALST EPALPDVAVV TVVPCPAGSG RETADRVHST 7201 TSEVLALVQW WLAEERAGRL ALVTRPGDLA HAAVWGLVRS AQSENPDRIV LVEAEETDEA 7261 VRVLPAALAS GEPQFAVRDG EVFVPRLVKA TRSATGTATG TPDFGVGPVL LTGASGALGG 7321 LVARHLVAEH GVRSLLLLSR RGAEAPGAVE LEAELAAWGA EVRWAACDVA DREAVSGMLN 7381 GLGEQSLSAV VHTAGVLGDG IVASLTPERM REVFRPKVDA VLNLHECTRD MGLAAFVVFS 7441 SVAGMVGSAG QASYAAANSF LDAFSAHRRR EGLPAISLAW GVWEQSGAMT DGLVEADRAR 7501 MARSGVLPLP PEEGLRLFDA ALASDEAVLA PVRIDTGALR AGEAPPVLRA LVPAAAARRT 7561 ARAAAAPSAS SLAERLEEMP EAEREKTVLD LVRAEVAAGL GHASDRTVRP EHAFQDLGFD 7621 SLTAVELRNR LNKATGLRLP ATLVFDHPTP ALLARHVFMA AAGAAEPALV DSLLADLDRV 7681 EQELVTTLAA SEARDRILSK LQGLLAIAGE FGKAPAQEGP GTGGSDLESA TDDEVFDLLG 7741 KEFGIS //