LOCUS BAC68126.1 6145 aa PRT BCT 07-OCT-2016
DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 modular
polyketide synthase protein.
ACCESSION BA000030-420
PROTEIN_ID BAC68126.1
SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893
ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
Streptomycetaceae; Streptomyces.
REFERENCE 1 (bases 1 to 9025608)
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
Contact:S Omura
Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
Kitasato, Sagamihara, Kanagawa 228-8555, Japan
URL :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE 2
AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
TITLE Complete Genome Sequence and Comparative Analysis of the
Industrial Microorganism Streptomyces avermitilis
JOURNAL Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE 3
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Genome sequence of an industrial microorganism Streptomyces
avermitilis: Deducing the ability of producing secondary
metabolites
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE 4
AUTHORS Ikeda,H., Shin-ya,K. and Omura,S.
TITLE Genome mining of the Streptomyces avermitilis genome and
development of genome-minimized hosts for heterologous expression
of biosynthetic gene clusters
JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT This work was done in collaboration with Haruo Ikeda(*1),
Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
Hattori(*1,*7)
and Satoshi Omura(*1,*3).
Final finishing process and all annotation were done by H. Ikeda
and J. Ishikawa.
*1 Kitasato Institute for Life Sciences, Kitasato University
*2 National Institute of Infectious Diseases
*3 The Kitasato Institute
*4 National Institute of Technology and Evaluation
*5 School of Science, Kitasato University
*6 Institute of Medical Science, University of Tokyo
*7 RIKEN, Genomic Sciences Center
All the annotated genes identified are available from following
urls.
http://avermitilis.ls.kitasato-u.ac.jp
FEATURES Qualifiers
source /db_xref="taxon:227882"
/mol_type="genomic DNA"
/note="This strain is also named as strain: ATCC 31267,
NCIMB 12804 or NRRL 8165."
/organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
/strain="MA-4680"
protein /gene="pteA4"
/locus_tag="SAVERM_416"
/old_locus_tag="SAV_416"
/transl_table=11
BEGIN
1 MDLSQTRRQL GELEAKDTEP IAIVGMACRY PGGVASPEEL WQLVASGGDG VSGFPTDRGW
61 DLDTIYDPEP GRTGRTYVRE GGFLYDAGEF DPAFFGISPR EALVMDPQQR LLLQTSWEAL
121 ERAGIDPVTA RGTRAGVFVG TNGQDHAYLQ RQGDSDSEAH LVTANTAAVV SGRISYALGL
181 EGPAVTVDTA CSSSLVALHL AAQALRRGEC SLALAGGVTV MATPNTFIAF SAQRGLSPDG
241 RCRAFSSTAD GTGMSEGIGV LLLERLSDAR RLGHEVLAVI RGSAVNQDGA SNGLTAPNGP
301 SQERVIRQAL ENARLTASQV DAVEAHGTAT TLGDPIEAEA LLATYGQEHS DDRPLWLGSI
361 KSNIGHTQAA AGVAGVIKMV MAIRNGVLPQ TLDVDEPTAQ VDWSAGGVKL LTEAVAWPES
421 DHPRRAAVSS FGVSGTNAHT IIEQAPALDR EPAAEPAGAP AAGALPWVLS AKSDAALRAQ
481 AERLLSFLED GRSGGTGPGR SPADIGFSLA TTRTAWDRRA AVVGESLEEL TEGVRALASG
541 TPSAAVVRNA ARHGDKTGFL FSGQGSQRLG MGRELYDAFP VFAAAYDEIR AHLDVALDAD
601 AEQLNQTGCT QPALFAVEVA LFRLLESWGV RPDYVAGHSV GEIAAAHVAG VLSLGDAARL
661 VSARAALMQA LPAGGAMVAV QAAEDEVVPH LTHGVGIAAI NGPRSVVVSG AEDAVLAIVE
721 VFTQQGCKTS RLMVSHAFHS PLMDPVLEEF AEVVRGLTFS EPRIPVVANL TGRLAEAYTP
781 EYWVRHVREA VRFADGIETL GELGVTTFVE IGPGGVLSAL VQGCFDDGTD IVTVPSLRAD
841 RPEPYALVTA LAELHVSGAE LDWHAFFPGA RRVDLPTYAF QQQRYWLEAR EAETATVDAV
901 DAEFWASVES EDAQSLAATL GLNPEELDVV VPKLSAWRRR RREQSVVDGR RYQLAWQPLN
961 GLSAGDLSGS TWLFAAPEGD EWAGTVRTAL AGRGAHLIPL TVGADADRAS LTDELTRVAG
1021 EAGSLDGVLS LLATDEIASP EHPALSQGFA QSVALAQALG DAGVDAPLWC ATRGAAATGR
1081 SDDAPLSAVQ NQVWGLGRAL ALEHARRWGG LIDLPAAVDE RAAGRIAAVL SQGADAADGQ
1141 EDQVAVRATG VFTARLAHAR SGVGRPWSPR GTVLITGGTG ALGGHVARWL AGAGAEHLVL
1201 TSRRGADAPG ATALKAELEE LGARVTLAVC DVADRDALAA LLAEHTFTSV FHAAGVEQFA
1261 PFDELTPADF ARTMAAKAHG AAHLDELLGD RELDAFVLFS SIAGVWGSGL QTAYAAGNAF
1321 LDGLAARRRA RGLTATAIAW GPWADGGMVT DADEAHLRRR GVVTLPAALA VTAVQRALDC
1381 DDTAVVVADI DWERFIGPFT FGRPSALLSE LPEVRRAGAV TAAVTAAPAD VGATPLAARL
1441 AGLPEAERTH TLIDLVRAHV AAVLGHSSAA EVEPDRAFKA LGFDSLTAVE LRNKVNTATG
1501 LALSPTLVFD YPNATALARF LQSELLGSQA VVEQEQHAAA DDEPIAIVAM SCHLPGGVDS
1561 PEALWDLVTS GGDAISEFPS NRGWDVEALY DPDPDRPGKT YARDGGFLYG ATDFDAGFFG
1621 ISPREALAMD PQQRLMLETS WEAFERAGIA PAQLRGSRTG VFVGMAYQGY GADVRRTPEG
1681 VEGHRLVGGA SSVVSGRVAY TFGLEGPAVT IDTACSSSLV ALHLAMQSLR NGECTMALAG
1741 GVTVMAGPSV FVEFSRQRGL SPDGRCRAFG ADADGTGWAE GVGMLLVERL SDARRNGHQV
1801 LAVVRGSAVN QDGASNGLTA PNGPAQQRVI HQSLASAGLA PRDVDAVEAH GTGTRLGDPI
1861 EAQALLATYG QGRDGDRPLW LGSLKSNIGH TQAAAGVAGV IKMVMAMRHG ILPRTLHADE
1921 PTPHVDWSAG DVRLLTEAVD WPESDRPRRA AISSFGVSGT NAHTIIEQAP ATAELPPTPD
1981 SGALVPWVLS GKGEPALRAQ AARLADHLDA NDGWTASDIG LSLASRETFE DRAVLLAQGS
2041 DKLRQALTAL AAGQPAANVT LGRARSEGKV GFLFSGQGSQ RIGMGRELYE AFPVFADAYD
2101 EVCARLEAPV DVDAETLHRT GCAQPALFAV EVALFRLLES WGVRPDYVAG HSVGEIAAAH
2161 VAGVLSLDDA VRLVSARAAL MQALPVGGAM VAVQATEEEV LPHLTDEVGI AAINGPRSMV
2221 LSGAGEAVTA IAEVFVGQGR KTSRLKVSHA FHSPLMDPML EEFAEVVRGL TFHQPQVPVV
2281 SNLTGRLAEP YSPEYWVRHV REAVRFADGI ETLGELGVTT FVEIGPGGVL SGMVQDCVDE
2341 AVTVPVLRGD RPEQQAVVTA LAELHVHGVS PDWQALFPGA HRVTLPTYAF QRERFWLDGE
2401 GDLAAAGTPT DAADSGFWDS VEREDAESLA ATLGVSADAS LGAILPRLSA WRRQRREQSV
2461 VDGWRYRVTW KPLGALPQPG ASGTWLLVVA GESEWTASVR TALDERGLEL VTLVAGPGTD
2521 RGTLARELAG VGPVTGVLSL LAEDESASAG DPGLSHGLAA TLCLVQALGD VGVDVPLWCA
2581 TRGAVATGRS DRVDRPLQSQ VWGFGRAAAL EHPRRWGGLL DLPELLDART AARVAAVLGQ
2641 TAEDQVAVRA SGVLGRRLVR AARATGPAQG WSPRGTVLIT GGTGALGGHV ARWLAGAGAE
2701 HLVLTSRRGP AAPGAAELVA ELEELGAAAT VVACDAADRD ALRALLAQHP VNAVVHAAGV
2761 GDHVMIEDSD PAGFAGSVAA KAAGATHLDE LLAGQELDAF VMFSSGAGIW GGAGQGAYSA
2821 ANAYLDALAE HRRAHGRTAL AVSWGGWAEG GMAGVGDGEE MLRRRGLPPM RPALAISALQ
2881 QALADGETAL TVADFDWERF IGPFTVTRPS ALFSDVPEAG RALEAPAPGG AEAGNALAAK
2941 LTGLPAAEQD RTLVDLVRTH AAAVLGHDGT AAVEPGRAFN DLGFDSLSAV ELRNKLTADT
3001 GLKLPTTLVF DYPNATALAR FLRAELLGSR GAARQEQRTA AVGDEPIAIV AMSCRLPGGV
3061 GSPEDLWQLV TSGGDVISGF PEDRGWNVEA LYDPDPGTPG KTYARDGGFL YDAGDFDAAL
3121 FGISPREALA MDPQQRLLLE ASWEAFERAG IDPASLKGSR TGVFVGMSYQ GYGAGLPQVP
3181 EGVEGHLLTG SAASVVSGRV AYSFGLEGPA VTVDTACSSS LVALHLAIQS LRNGESTMAV
3241 AGGVNVMAVP AAFVEFSRQR GLAPDGRCKA FGAGADGTGW AEGVGVVLVE RLSDAVRNGH
3301 EILAVVRGSA VNQDGASNGL TAPNGPAQQR VIRQALASAG LTEADVDAVE AHGTGTALGD
3361 PIEAQALLAT YGQERPEDRP LWLGSLKSNI GHAQAASGVA GVIKMVMAMR HGVLPRTLHA
3421 DEPTPHVDWS AGAVRLLTEA VGWPDTNRPR RAAISSFGVS GTNAHTIIEQ APVAEPAAVA
3481 PVEVSSATVP WVLSGKSEAA LRAQAERLLT LTADGAEPSL TDVGFSLATT RAALEHRAAV
3541 VGADHGRIAE GLRALASGAP APGAVLGRAD AGQVGFLFSG QGSQRIGMGR QLYEAFPVFA
3601 EAYDEVCAHL DRHLDRPLRD VAFGENGHED GEELNRTAFT QPALFAHEVA VHRLLESWGV
3661 RPDYLAGHSV GEIAAAHVAG ALALEDAAAL VTARAALMQA LPAGGAMIAV QATEDEVLPH
3721 LTDDAGIAAI NGPQSVVVSG TEDAVAAVAD FFAREGRKIS RLTVSHAFHS PLMDPVLEDF
3781 ARVVGGLRFE TPRTPVVSNL TGELIDAYTA DYWVRHVREA VRFADGIRTL GELGVTTFVE
3841 TGPGAVLSAM AQGCLDGAVA VASARSGSPE PEAITGALAQ LHVHGVPVDW RAFFAGRGAR
3901 RADLPTYAFQ HQRYWLETTA PTAAAGTDAV ETGFWETVER EDAQSLAATL ELPVEQLDAV
3961 LPRLSAWRRQ QRRESAVEGW SYRTGWKPLS GLRAHELRGN WLFLVTEDTE AFEAFEWTAA
4021 VADGLAARGA RLVRVTVDPA ADRGALLRQL GEAVRESPLD GVISLLGIDE RHHAGHPALS
4081 VGTVLTLALV QALGDAGIDA PLWALTRSAM STGRADAVPS AAQNAVWGLG RVAALEHAPR
4141 WGGLIDLPDT VDDRIAGRLA AVLAQSAEDQ VAIRDRGVFG RRLSHTAARR NTRAAQGWSP
4201 RGTVLITGGT GALGGHVARW LAGAGAEHLV LTSRRGPDAP GAAGLVAELE ATGVRVTVAA
4261 CDVADREALA ALLAEHPVNA VVHTAGVDHM EPLEAMTPGA CADVLSAKAA GALHLDALLA
4321 GQELDAFVLF SSIAGVWGSG HQAAYAAANA LLDGLAERRR AQGLPATAVA WGPWAGGGMA
4381 EADGADERLR RRGLIPMPAA LAVAGLRRAL DSGEATATVA DVDWERFLPP FTVGRPSALL
4441 GDLPEAERIL TADSTAGGPG TAAASPLADR LARMPETEQH ALLVDLVRTH AAAVLGHNNA
4501 GEVEADRAFK DLGFDSLTAV ELRNKLKAET GLALPPTLVF DHPNAQALAR QLRTELTGLT
4561 IAAAPEAAAA PAEDEEPIAI VGMACRYPGG VRSPEDLWHL VAAGGDAVGD FPADRGWDVE
4621 DIYDPDPDAR GKTYARRGGF LYEAGEFDPG FFGISPREAV AMDPQQRLLL ETTWETFERA
4681 GIDAESVRGS RTGVFVGSGY QDYAARAFNA IDDSEGFFGT GNSASIMSGR IAYTFGLEGP
4741 AVTVDTACSS SLVALHWAIQ ALRNGECSMA LAGGVMVMST PRAFVEFSRQ RGLAPDGRCK
4801 AFGADADGTG WAEGVGMLLV ERLSDARRNG HQVLAVVRGS AVNQDGASNG LTAPNGPAQQ
4861 RVIRQALTSA GLTAADIDAV EAHGTGTRLG DPIEAQALLA TYGQERPAGQ PLWLGSLKSN
4921 IGHTQAAAGV AGVIKMVMAM RHGVLPQTLH VDEPTPHVDW SAGDVRLLTE AVAWPESERP
4981 RRAAVSSFGV SGTNAHTIIE QAPPVPAEEA TVTPAPALLP WVLSAKSSAA LRDQARRLLA
5041 FVEDGMSLAD VGFSLATTRS ALRHRAAVIG ESGDGFRRGL GSLAAGMPSP GVVQGRPGGK
5101 VGFLFSGQGS QRIGMGRELY EAFPVFADAY DEVCARLEAP VDVDAETLHR TGCAQPALFA
5161 VEVALFRLLE SWGVRPDYVA GHSVGEIAAV HVAGVLSLDD AVKLVSARAA LMQALPAGGA
5221 MVAVQATEDE VLPHLTDGVG MAAINGPRSV VVSGAEDAVL EIAEVFTRQG RKTSRLKVSH
5281 AFHSPLMDPM LEEFAEVVRG LTFHQPQVPV VSNLTGRLAE PYSPEYWVRH VREAVRFADG
5341 IETLGELGVT TFVEIGPGGV LSGMVQDCVD EAVTVPVLRG DRPEQQAVVT ALAHLHTHGM
5401 SVDWNVFFAG ARKADLPTYA FQHEPYWVDA PQIAAAAEAE PVDAEFWETV ERGDLQALAE
5461 TLGVGAGDKF GDVLPRLSSW RRQRKEQSTV DTWRYGESWK GIPDRVPEGP ARIGLWLVPV
5521 SAAQLGDDWV TACLRGLTER GLAPLPVPVE PATGREDLAA QLTRAAGDET VAGVLSLLAV
5581 DCGAAPAAAA LTVGVALSVL LVQALGDAGI GAPLWCVTRN AVGVSTADEA TDPYQSQVWG
5641 LGRVAALEHA PRWGGLIDLP DTVDDRIAGR LAAVLGQSAE DQVAIRDRGL FVRRLSRLPA
5701 ALSERSWSPR GTVLITGGTG ALGGHVARWL AGAGAEHLVL TSRRGPAAPG AAGLKAELEE
5761 AGVRVTVAAC DVADREALAV LLAEHPVNAV VHTAGTAEAG MLAETSLGDF AATVAAKALG
5821 AVHLHELLGD QELDAFVLFS SISGVWGGGG QAAYSAANAF LDGLAQHRRA RGLAATAIAW
5881 GPWGEGGMVA DAGDEERLRQ RGLSVLRPDR AISALHGALS GGDGTVTVAD VDWERFVVPF
5941 TIGRPSALLS DLPEVGDALA EKRTERAAEP SALKAKLSTL SEGERQRLLV DTVCAHAAAV
6001 LGHSGSAAVD PDLAFRDLGF DSLTAVELRN LLSADTGLTL PATLVFDHPT PEAIARYLRS
6061 ELADETGPEE VSVFSELDRL ESVISTAASA EQTVRSGVRR RLQELLSLVN SAGEQGAESA
6121 DAQRQLQDAT IDDIFDLIDQ DLEIS
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