LOCUS D85376 4799 bp DNA linear HUM 16-OCT-2004
DEFINITION Homo sapiens gene for thyrotropin-releasing hormone receptor,
complete cds.
ACCESSION D85376 D85375
VERSION D85376.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4799)
AUTHORS Yamada,M.
TITLE Direct Submission
JOURNAL Submitted (14-MAY-1996) to the DDBJ/EMBL/GenBank databases.
Contact:Masanobu Yamada
Gunma University School of Medicine, First Department of Internal
Medicine; 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
REFERENCE 2
AUTHORS Yamada,M.
JOURNAL Unpublished (1996)
REFERENCE 3
AUTHORS Iwasaki,T., Yamada,M., Satoh,T., Konaka,S., Ren,Y., Hashimoto,K.,
Kohga,H., Kato,Y. and Mori,M.
TITLE Genomic organization and promoter function of the human
thyrotropin-releasing hormone receptor gene
JOURNAL J. Biol. Chem. 271, 22183-22188 (1996)
COMMENT
FEATURES Location/Qualifiers
source 1..4799
/chromosome="8"
/db_xref="H-InvDB:HIT000391592"
/db_xref="taxon:9606"
/mol_type="genomic DNA"
/organism="Homo sapiens"
regulatory 1..457
/regulatory_class="promoter"
5'UTR join(458..713,1255..1342)
exon 458..713
/number=1
/product="thyrotropin-releasing hormone receptor"
intron 714..1254
/number=1
exon 1255..2131
/number=2
/product="thyrotropin-releasing hormone receptor"
CDS join(1343..2131,2285..2692)
/codon_start=1
/product="thyrotropin-releasing hormone receptor"
/protein_id="BAA12796.1"
/translation="MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNI
MVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCIT
YLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLW
FFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARIL
FLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFA
LLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKL
CNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASE
VSFSQS"
intron 2132..>2161
/note="5'portion of intron 2"
/number=2
gap 2162..2261
/estimated_length=unknown
intron <2262..2284
/note="3'portion of intron 2"
/number=2
exon 2285..4798
/number=3
/product="thyrotropin-releasing hormone receptor"
3'UTR 2693..4798
regulatory 4768..4773
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1423 a 922 c 862 g 1492 t
ORIGIN
1 actaattttc cattcacaaa atatgagagg aggaagccaa ttgtactgat tcacttgaga
61 aacagtacaa gggttttcat agtagagaaa gaggttgatt tcagctcaga cagatatttc
121 aagcttcaag ggccatgtct agactgagaa ggatttgcta accccaaagt cctatcaagc
181 aaggagtgta aatgtatttc agagcagctc aggtactaga gtttctgcag aacttagatg
241 ataagcaacg acaaagccag ctgcttctag acccctggct tatgatttca gctttccaaa
301 ttaaagactg tctcatcagc acatttaata gtaaatcctc caagagcaga agactctgaa
361 tcagtgagga ctgactggca tctgtgagtg tgtgtgaatg tatgtgtgtg tgtgtgtgtg
421 tgtctctgtg tgtgagagag cgagcgtgta tgttctcatt aggggacgat ctatgatttg
481 acagcctcac tgctgctgct cctgctgctg cttctgcttc tgccgcggct gtatggtttg
541 tcattagttg gaaagggctg tgagggtttg gagaaactgc agttttaaag actgagcact
601 gctaagtggt ctccctctca aatagagtag acaagatttt ctgcaagatt agaaacttgg
661 aactattacc acttcatcta cccagaaaat caggcagcgc tacagaggat aaggtaagag
721 aagaaattgt cctctcttga atctgtgggg cagggggcat ggggaaatgt catctcaaag
781 gcttgctatt ttataccaaa gacatctcac cctctgagag caaaagaggc aacagctaaa
841 tttgtaacaa gcttgattat tgagcttctt ggctttttcc tctggtatct ttttcttctt
901 tattatactt ttgccaggca tctaagaggt gtattcatat ttatttttca gttagcagat
961 atttagtttt tttcaactgg gcactgtttc aaaacaatta gtttttactg tttctctttc
1021 cttaagcatt tttctccatt aagagggaac tggtccctct taatgtgagc tggtcaaaac
1081 agttactcca ttctacacta gagatgcaat aaaagaagtt ttaagaagta cacatgagcc
1141 ctattcccat agaaaaatgg gaagtgaaag gagtggaagt gacggttatt tgtgattggg
1201 acttgatcag aaattgtaac actgttaatg aatatgtact atgacccttc acagggggat
1261 ggaactgctg caataaaggt gggcgctgga aagaagatgt tttgagaagt cagtgtttcc
1321 gagaaacttt aagcttctaa agatggaaaa cgagacagtc agtgaactga accaaacaca
1381 gcttcagcca cgagcagtgg tggccttaga ataccaggtg gtcaccatct tacttgtact
1441 cattatttgt ggcctgggca ttgtaggcaa catcatggta gtcctggttg tcatgagaac
1501 caagcacatg aggaccccca caaactgcta cctggtgagc ctggcagtag ctgatctcat
1561 ggtcttggtg gccgcaggcc tccccaacat aacagacagt atctacggtt cctgggtcta
1621 tggctatgtt ggatgcctct gcattactta cctccagtat ttgggaatta atgcatcctc
1681 ttgttcaata acagccttta ccattgagag gtacatagca atctgtcacc ccatcaaagc
1741 ccagtttctc tgcacatttt ccagagccaa aaagattatc atctttgtct gggctttcac
1801 atctctttac tgtatgctct ggttcttctt gctggatctc aatattagca cctacaaaga
1861 tgctattgtg atatcctgtg gctacaagat ctccaggaat tactactcac ctatttacct
1921 aatggacttt ggtgtctttt atgttgtgcc aatgatcctg gctaccgtcc tctatggatt
1981 catagctaga atccttttct taaatcccat tccttcagat cctaaagaaa actctaagac
2041 atggaaaaat gattcaaccc atcagaacac aaatctgaat gtaaatacct ctaatagatg
2101 tttcaacagc acagtatctt caaggaagca ggtaagcaaa actgaaactc caagtcaata
2161 gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nattttctct ctatttctcc
2281 ctaggtcacc aagatgctgg cagtggttgt aattctgttt gcccttttat ggatgcccta
2341 caggactcta gtggttgtca actcatttct ctccagtcct ttccaagaaa attggttttt
2401 gctcttttgc agaatttgca tttatctcaa cagtgccatc aacccggtga tttacaatct
2461 catgtcccag aaattccgtg cagccttcag aaagctctgc aactgcaagc agaagccaac
2521 agagaaacct gctaactaca gtgtggccct aaattacagc gtcatcaagg agtcagacca
2581 tttcagcaca gagcttgatg atatcactgt cactgacact tacctgtctg ccacaaaagt
2641 gtcttttgat gacacctgct tggcttctga ggtatccttt agccaaagtt gattcatgaa
2701 ttagaagaaa atggatgaca aagaaaatga gaatctgtgc agtcatcaac aaaagggaga
2761 acatggccaa tagtcatatg tgaagacaga gcagatcagt ctttgtcaat gctctaacaa
2821 attctggccc tagatacttt aacccatgag gatgattcag actttccttc ttacaaacta
2881 atatcactaa aaatggagca gatctgtgaa atagctaaat gatggaaact taaagtttag
2941 cccttttcat ttaacttaag aaattcacta tattttctgg acttatagag tttcaataaa
3001 atctagacat caatttacat tattcatagt aaccttatca aatgtcactt ttcaacttcc
3061 ctaatttatt tatacattcg ataatttgac aacatgcaga tttttaaatg tttgcattta
3121 gtattcattt taacatagta cagggctagt tcatgaatat ctgaaattaa agggaaaaat
3181 attacagaaa cattttattt attgagtaaa aataagattt tagacataca tgttaactgt
3241 attttaaaag ttgccataat gtttataaaa ttctgagatg atttttatat cttagaaggt
3301 agataatcat cactcaactt taatgtaaaa taaacctcaa aatatctgaa attattaatt
3361 aaggagaaat gtagatttta agataaatcc aactcttatc aactcttcca gcctcccaca
3421 tgatgggtgg aaaaaggcaa aagcccagat taagtaactg tgaagataca aactaacata
3481 caattaaatt tgaaaagtat agtcaagaca aagcaagtat ttataattag attttgcttc
3541 ttctctgacg cttttaagca ataaaatctt tttgaacatt cttgtttata aactactcag
3601 ccatgtcaag caaatcattc aagcaaaatc tagctgaaaa gtctgaaaca ttcttaaaag
3661 ctttgttatt ctaagtcagc caaaatcctg gtatccctct tccagataaa gagctcccac
3721 tgagaattgt agtctatgga ttttaccttg actgcaattg tctttccttc ctatctgctt
3781 gttgtttgta ggttcttttt ttgtttttct caaatgctag tgatattttg tttacagatt
3841 ctaaaagcaa tgcaaaattc tgttggcttt attttcagca gagttaaaac tgatttcatc
3901 atattatcag tatgtcatct ttatatttat gactgacatc tgctattcca gtgtttattg
3961 gagacttgtg aatgaatctg tccaggacac ttgtcagttc ctacctgaat ctcttaccta
4021 ttgagatttg gccaaccaga atctccgagg gcaaaaattg cccttggtga tggttcagta
4081 gtcattgatt tttaatgagt agatcaaaaa agtacccata cctttacatg cccgtaggct
4141 gtcattttcc ctctccagcc tatatcccta ttttatggac ttttctagaa cctaatcgct
4201 aatgataatt atgcctcccc atcttcttaa tgaagaatat accattcttc tgaaacttgt
4261 ttttacgtgc tgtttcatgg agactatgct atccagaacc tcattctaga gtgcgctttt
4321 ttttttttga aaattggcct tatctactcc agcaagacat ttttatcctg ttactataac
4381 agtaaatgaa tgcaagcaaa tatttgcagg aaatacccta aaaccctacc tgcatgacag
4441 taagcaatct atgttaactg acttttcatt ctggtataaa tattaatctt ggcatcatat
4501 aaatagagca ccagagtgac ccaaccccaa atcacacaag cacatgtgtg tttataaaca
4561 catacccaca tgttcataaa ttggtgaaaa aggggattgg aatatacgag attttttcat
4621 tacagaaagg acctaatatc attgagcatc gactatgtct caggtatgct ggtaggtagt
4681 caatcaacat tatcttcatc acaatttcac tacagctgta atttctctga tgattagacc
4741 agtattcctg tgacctaatt cctaattaat aaaaagttat ggattttgca gaatgatta
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